Research of the Cortese-Krott lab include three major areas:
The main goal of the Cortese-Krott lab is to enhance knowledge of the molecular mechanisms underlying cardiovascular disease including hypertension and acute myocardial infarction. Applying a translational approach to research, involving a multilevel analysis of chemical, biochemical and pharmacological studies, we hope to contribute to the development of new diagnostics and therapeutic tools for reducing death and disability due to cardiovascular diseases.
- Red blood cell function and dysfunction in acute myocardial infarction and cardiovascular disease.
- Chemistry, biochemistry and pharmacology of nitric oxide and sulfide in regulation of vascular tone and blood pressure.
- Tissue-specific conditional mouse models of nitric oxide metabolism.