Research Group Kelm

Main research topics

  • Coronary blood flow, ischemia/reperfusion
  • Nitric oxide metabolism, endothelial function
  • Flavanols, nutrition and cardiovascular function
  • Interventional therapy of acute myocardial infarction and structural heart disease

Current projects

  • Role of anemia during acute myocardial infarction
  • Red blood cell derived NO signalling
  • Dysfunction of reed blood cells in comorbidities


  • Vice spokesperson of the Collaborative Research Centre (SFB) 1116
  • Principal Investigator in the International Research Training Group IRTG 1902
  • Board member of the graduate school VIVID ("in vivo models for human metabolic diseases", University of Düsselodrf)
  • Adjunct member of the Collaborative Research Centre (SFB) 612
  • Scientific director of Med-in-NRW (Heart Valve Initiative, North Rhine-Westphalia)
  • Scientific director of the EU-consortium FLAVIOLA (FP 7), Title: "Targeted delivery of dietary flavanols for optimal human cell function: Effects on cardiovascular health"

Selected publications

  • Spieker M, Katsianos E, Gastl M, Behm P, Horn P, Jacoby C, Schnackenburg B, Reinecke P, Kelm M, Westenfeld R, Bönner F. T2 mappingcardiovascularmagneticresonanceidentifiesthepresenceofmyocardialinflammation in patientswithdilatedcardiomyopathyascomparedtoendomyocardialbiopsy. Eur Heart J CardiovascImaging. 2018 May 1;19(5):574-582.
  • Navarese EP, Kołodziejczak M, Schulze V, Gurbel PA, Tantry U, Lin Y, Brockmeyer M, Kandzari D, Kubica JM, D’Agostino RB, Kubica J, Volpe M, Agewall S, Kereiakes DJ, Kelm M. Safety and Efficacy of PCSK9 antibodies in patients with hypercholesterolemiaSystematic review and meta-analysis of randomized controlled trials. Ann Intern Med. 2015 doi: 10.7326/M14-2957
  • Navarese EP, Andreotti F, Schulze V, Kołodziejczak M, Buffon A, Brouwer M, Costa F, Kowalewski M, Parati G, Lip GYH, Kelm M. Optimal Duration of Dual Antiplatelet Therapy after Percutaneous Coronary Intervention with Drug-Eluting Stents. Meta-analysis of Randomized Controlled Trials. BMJ 2015; 2015;350:h1618.
  • Polzin A, Zeus T, Schror K, Kelm M, Hohlfeld T. Dipyrone (metamizole) can nullify the antiplatelet effect of aspirin in patients with coronary artery disease. Journal of the American College of Cardiology 2013;62:1725-1726.
  • Hendgen-Cotta UB, Luedike P, Totzeck M, Kropp M, Schicho A, Stock P, Rammos C, Niessen M, Heiss C, Lundberg JO, Weitzberg E, Kelm M, Rassaf T. Dietary nitrate supplementation improves revascularization in chronic ischemia. Circulation. 2012 Oct 16;126(16):1983-92.
  • Totzeck M, Hendgen-Cotta UB, Luedike P, Berenbrink M, Klare JP, Steinhoff HJ, Semmler, D, Shiva S, Williams D, Kipar A, Gladwin MT, Schrader J, Kelm M, Cossins AR, Rassaf T. Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation. Circulation. 2012;126:325-34.
  • Kleinbongard P, Schulz R, Rassaf T, Lauer T, Dejam A, Jax T, Kumara I, Gharini P, Kabanova S, Ozüyaman B, Schnürch HG, Gödecke A, Weber AA, Robenek M, Robenek H, Bloch W, Rösen P, Kelm M. Red blood cells express a functional endothelial nitric oxide synthase. Blood. 2006 Apr 1;107(7):2943-51.
  • Rassaf T, Bryan NS, Maloney RE, Specian V, Kelm M, Kalyanaraman B, Rodriguez J, Feelisch M. NO adductsin mammalian red blood cells: too much or too little? Nat Med 2003, 9: 481-482
  • Heiss C, Dejam A, Kleinbongard P, Schewe T, Sies H, Kelm M. Vascular effects of cocoa rich in flavan-3-ols. JAMA (2003) 290: 1030-1031.
  • Kelm M, Schrader J. Control of coronary vascular tone by nitric oxide.Circ Res (1990) 66: 1561-1575
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