Main research topics

• Coronary blood flow, ischemia/reperfusion
• Nitric oxide metabolism, endothelial function
• Flavanols, nutrition and cardiovascular function
• Interventional therapy of acute myocardial infarction and structural heart disease

Current projects

• Role of anemia during acute myocardial infarction
• Red blood cell derived NO signalling
• Dysfunction of reed blood cells in comorbidities

Collaborations

• Vice spokesperson of the Collaborative Research Centre (SFB) 1116
• Principal Investigator in the International Research Training Group IRTG 1902
• Board member of the graduate school VIVID ("in vivo models for human metabolic diseases", University of Düsselodrf)
• Adjunct member of the Collaborative Research Centre (SFB) 612
• Scientific director of Med-in-NRW (Heart Valve Initiative, North Rhine-Westphalia)
• Scientific director of the EU-consortium FLAVIOLA (FP 7), Title: "Targeted delivery of dietary flavanols for optimal human cell function: Effects on cardiovascular health"

Selected publications

• Spieker M, Katsianos E, Gastl M, Behm P, Horn P, Jacoby C, Schnackenburg B, Reinecke P, Kelm M, Westenfeld R, Bönner F. T2 mappingcardiovascularmagneticresonanceidentifiesthepresenceofmyocardialinflammation in patientswithdilatedcardiomyopathyascomparedtoendomyocardialbiopsy. Eur Heart J CardiovascImaging. 2018 May 1;19(5):574-582.
• NavareseEP, Kołodziejczak M, Schulze V, Gurbel PA, Tantry U, Lin Y, Brockmeyer M, Kandzari D, Kubica JM, D’Agostino RB, Kubica J, Volpe M, Agewall S, Kereiakes DJ, Kelm M. SafetyandEfficacyof PCSK9 antibodies in patientswithhypercholesterolemia –Systematicreviewand meta-analysis ofrandomizedcontrolledtrials. Ann Intern Med. 2015 doi: 10.7326/M14-2957
• Navarese EP, Andreotti F, Schulze V, Kołodziejczak M, Buffon A, Brouwer M, Costa F, Kowalewski M, Parati G, Lip GYH, Kelm M. Optimal Duration of Dual AntiplateletTherapy after PercutaneousCoronary Intervention with Drug-Eluting Stents. Meta-analysis ofRandomizedControlled Trials. BMJ 2015; 2015;350:h1618.
• Polzin A, Zeus T, Schror K, Kelm M, Hohlfeld T. Dipyrone (metamizole) can nullify the antiplatelet effect of aspirin in patients with coronary artery disease. Journal of the American College of Cardiology 2013;62:1725-1726.
• Hendgen-Cotta UB, Luedike P, Totzeck M, Kropp M, Schicho A, Stock P, Rammos C, Niessen M, Heiss C, Lundberg JO, Weitzberg E, Kelm M, Rassaf T. Dietary nitrate supplementation improves revascularization in chronic ischemia. Circulation. 2012 Oct 16;126(16):1983-92.
• Totzeck M, Hendgen-Cotta UB, Luedike P, Berenbrink M, Klare JP, Steinhoff HJ, Semmler, D, Shiva S, Williams D, Kipar A, Gladwin MT, Schrader J, Kelm M, Cossins AR, Rassaf T. Nitrite regulateshypoxicvasodilation via myoglobin-dependentnitricoxidegeneration. Circulation. 2012;126:325-34.
• Kleinbongard P, Schulz R, Rassaf T, Lauer T, Dejam A, Jax T, Kumara I, Gharini P, Kabanova S, Ozüyaman B, Schnürch HG, Gödecke A, Weber AA, Robenek M, Robenek H, Bloch W, Rösen P, Kelm M. Redbloodcells express a functionalendothelialnitricoxidesynthase. Blood. 2006 Apr 1;107(7):2943-51.
• Rassaf T, Bryan NS, Maloney RE, Specian V, Kelm M, Kalyanaraman B, Rodriguez J, Feelisch M. NO adductsinmammalianredbloodcells: toomuchortoolittle? NatMed 2003, 9: 481-482
• Heiss C, Dejam A, Kleinbongard P, Schewe T, Sies H, Kelm M. Vasculareffectsofcocoarich in flavan-3-ols. JAMA (2003) 290: 1030-1031.
• Kelm M, Schrader J. Control ofcoronaryvascular tone bynitricoxide.Circ Res (1990) 66: 1561-1575