Research Group Polzin

Main research topics

  • Sphingolipids in cardioprotection
  • Platelets/anticoagulants in acute myocardial infarction

Current projects

  • Cardioprotection by aspirin
  • S1P lyase inhibition in acute myocardial infarction
  • NOACs and platelet reactivity
  • Role of platelets beyond thrombosis during acute myocardial infarction

Collaborations

  • Prof. Dr. med. B. Levkau (University Duisburg-Essen)


Selected publications

  • Polzin A, Zeus T, Schror K, Kelm M, Hohlfeld T. Dipyrone (metamizole) can nullify the antiplatelet effect of aspirin in patients with coronary artery disease. Journal of the American College of Cardiology 2013;62:1725-1726
  • Polzin A, Richter S, Schror K, Rassaf T, Merx MW, Kelm M, Hohlfeld T, Zeus T. Prevention of dipyrone (metamizole) induced inhibition of aspirin antiplatelet effects. Thromb Haemost 2015;114:87-95.
  • Dannenberg L, Erschoff V, Bonner F, Gliem M, Jander S, Levkau B, Kelm M, Hohlfeld T, Zeus T, Polzin A. Dipyrone comedication in aspirin treated stroke patients impairs outcome. Vascular pharmacology 2016;87:66-69.
  • Polzin A, Dannenberg L, Sansone R, Levkau B, Kelm M, Hohlfeld T, Zeus T. Antiplatelet effects of aspirin in chronic kidney disease patients. Journal of thrombosis and haemostasis : JTH 2016;14:375-80.
  • Polzin A, Dannenberg L, Sophia Popp V, Kelm M, Zeus T. Antiplatelet effects of clopidogrel and aspirin after interventional patent foramen ovale/ atrium septum defect closure. Platelets 2016;27:317-21.
  • Achilles A, Mohring A, Dannenberg L, Grandoch M, Hohlfeld T, Fischer JW, Levkau B, Kelm M, Zeus T, Polzin A. Dabigatran enhances platelet reactivity and platelet thrombin receptor expression in patients with atrial fibrillation. Journal of thrombosis and haemostasis : JTH 2017;15:473-476.
  • Achilles A, Mohring A, Dannenberg L, Piayda K, Levkau B, Hohlfeld T, Zeus T, Kelm M, Polzin A. Analgesic medication with dipyrone in patients with coronary artery disease: Relation to MACCE. International journal of cardiology 2017;236:76-81.
  • Polzin A, Piayda K, Keul P, Dannenberg L, Mohring A, Graler M, Zeus T, Kelm M, Levkau B. Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. Journal of molecular and cellular cardiology 2017;110:35-37.
  • Helten C, Naguib D, Dannenberg L, Pohl M, Ayhan A, Hohlfeld T, Levkau B, Kelm M, Zeus T, Polzin A. Platelet function testing: dead or alive. Journal of thrombosis and haemostasis : JTH 2018;16:984-986
  • Piayda K, Zeus T, Sievert H, Kelm M, Polzin A. Subclinical leaflet thrombosis. Lancet 2018;391:937-938.
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