Leanne Demay is a PhD candidate at Stony Brook University New York in the Department of Anthropology and currently a visiting researcher at the C.&O. Vogt Institute of Brain Research. Her dissertation is a comparative analysis of the cerebellar lobules of primates. Here on site, she has the opportunity to use our extensive histological brain slice collection to analyze the interspecific variables based on high-resolution scans of the cerebellar lobules of various primate species. We wish Leanne a good start to her project and a pleasant stay with us in Düsseldorf.
We are very happy that Rouven Fleischmann and Simon Werker have joined our team. A warm welcome! We wish you all the best for your start and are looking forward to working with you. Rouven will support us as a biological-technical assistant in the lab and Simon will help out as a student assistant.
On September 30th, the Human Brain Project (HBP) formally completes its 10-year runtime as an EU-funded FET Flagship. The project has pioneered digital neuroscience, a new approach to studying the brain based on multidisciplinary collaborations and high-performance computing. The HBP will continue to have an impact on neuroscience for many years through the EBRAINS research infrastructure and a new way of collaborative work in the field.
Read the further article here.
After 10 years , the EU Flagship Human Brain Project will come to an end on 30 September. We’re very proud to have been a partner of the project.
Learn more about the project’s achievements here https://www.humanbrainproject.eu/ #celebratingHBP
The EU-funded Human Brain Project (HBP) comes to an end in September and celebrates its successful conclusion today with a scientific symposium at Forschungszentrum Jülich (FZJ). The HBP was one of the first flagship projects and, with 155 cooperating institutions from 19 countries and a total budget of 607 million euros, one of the largest research projects in Europe. Forschungszentrum Jülich, with its world-leading brain research institute and the Jülich Supercomputing Centre, played an important role in the ten-year project.
Read more here.
We are very happy to welcome Dr. Lucija Rapan as a new research associate at the Cécile & Oskar Vogt Institute of Brain Research.
Lucija will support our research and teaching activities from now on. Her research focus is the characterization of the cytoarchitecture and receptor architecture of the posterior cingulate and retrosplenial cortex of humans and macaques.
We wish you a good start, Lucija!
The application portal is open from September 1st 2023 until December 1st 2023 for intake 2024!
Please find further information on their website: https://cognition.maxplanckschools.org/en/application
Together with Prof. Dr. Markus Axer (Bergische Universität Wuppertal/FZ Jülich) we participated in the action day "Nature Protection, Species Protection and Climate Protection" of our cooperation partner "The Green Zoo Wuppertal". We presented the brain diversity of different species all visualized by 3D polarization microscopy. Besides, we showed impressive specimens from our brain and brain slice collection - from orangutans to crocodiles. Our young as well as adult visitors enjoyed our little memory game "Which brain belongs to which species?". Our visitors themselves could also experience the physics behind that 3D-PLI method by using our "hand polarimeter" and could try themselves in further experiments. Our stickers were very popular and were taken home by many visitors. We were supported by our students Alina Hansen (M.Sc. Psychology) and Kevin Flink (B.Sc. Medical Physics). We would like to thank the whole team of the Wuppertal Zoo and especially our cooperation partner Dr. Dominik Fischer for this successful event! Next year we will be back to inspire again many visitors and future scientists, and with that, making a lasting contribution to our planet. Author: PD Dr. Christina Herold, Source photos: Wuppertal Institute / L.Schenk
We would like to kindly invite you to participate in the 1st EBRAINS National Node Germany Workshop which will take place on September 26, 2023 in Berlin from 09:00-13:30 CET.
- Dr. Seán Froudist-Walsh, University of Bristol
- Prof. Dr. Thomas Wachtler, Ludwig-Maximilians-University Munich
- Prof. Dr. Lena Oden, FernUni Hagen & FZ Jülich
- Prof. Dr. Bryan Strange, Technical University Madrid
- Dr. Andreas Rowald, Friedrich Alexander University Erlangen-Nürnberg
- Prof. Dr. Petra Ritter, Charité – Universitätsmedizin Berlin
- Prof. Dr. Thanos Manos, Cergy Paris University
For further details and for registration please browse to our event website
The EBRAINS National Node Germany (NNG) invites to the 1st EBRAINS NNG Workshop as a back-to-back event of the Bernstein Conference 2023 in Berlin, Germany. You will hear about the EBRAINS RI, its usage, an Expert Discussion on “Digital tools to bridge the gap between experimental and computational neuroscience” and will have the opportunity to network during our NNG lunch.
EBRAINS is a unique digital Research Infrastructure (RI), created by the EU-funded Human Brain Project. It is an open platform providing an extensive range of data and tools to enhance brain-related research. EBRAINS is a pan-European distributed network of services, that will in the future be organized through National Nodes.
The EBRAINS NNG currently encompasses about 40 universities and research institutions across Germany joining forces to develop a common scientific and technical strategy, addressing the major scientific challenges of our time. The EBRAINS NNG partners offer unique services, including science liaison activities, for basic neuroscience, medical applications, and industry in the fields of:
- High-Performance Computing
- Neuromorphic Computing
- Artificial Intelligence
- Information privacy and security
Nicola Palomero-Gallagher, Fabrice Morin, Francesca Cavallaro, Björn Kindler, Sandra Diaz, Maren Frings
In case of further questions please don’t hesitate to contact firstname.lastname@example.org
Our Master's program in Translational Neuroscience is becoming more and more visible and popular every year - both nationally and internationally. More and more young scientists are interested in obtaining a Master's degree in neuroscience and are applying for our program here at Heinrich-Heine-University Düsseldorf. This year we have already set a new record and exceeded 300 applications. That is +18.2% more applications than last year and even 4 times more than in 2016 - when our program was launched for the very first time. We wish all applicants good luck and every success! We will personally welcome 20 of you here in Düsseldorf for the start of the winter semester 2023/24 in October. And, you can still apply!
The application deadline is on Saturday, the 15th of July 2023, 23:59 o’clock:
HBP researchers from Germany performed detailed cytoarchitectonic mapping of distinct areas in a human cortical region called frontal operculum and, using connectivity modelling, linked the areas to a variety of different functions including sexual sensation, muscle coordination as well as music and language processing.
You can find the complete article here.
Nina Unger, Martina Haeck, Simon B. Eickhoff, Julia A. Camilleri, Timo Dickscheid, Hartmut Mohlberg, Sebastian Bludau, Svenja Caspers and Katrin Amunts. Cytoarchitectonic mapping of the human frontal operculum-New correlates for a variety of brain functions. Front. Hum. Neurosci., 28 June 2023 – Sec. Speech and Language. Volume 17 – 2023. doi : 10.3389/fnhum.2023.1087026
Our colleague Felix Ströckens has recently published two highly interesting research studies in the journal communications biology.
The study on hemispheric asymmetries and brain size in mammals was done in collaboration with the Medical School and the Institute for Cognitive and Affective Neuroscience in Hamburg and the Institute for Cognitive Neuroscience at Ruhr University Bochum. If you want to know more about why larger-brained species tend to evolve into more right-lateralized individuals, we highly recommend this article.
Ocklenburg S, El Basbasse Y, Ströckens F, Müller-Alcazar A. Hemispheric asymmetries and brain size in mammals. Commun Biol 2023; 6(521), https://doi.org/10.1038/s42003-023-04894-z
The second study already has the delightful title ‚From Fossils to Mind‘. Fossil endoclasts preserved features of brains from the past (such as size, shape, vasculature, and gyrification) that can be used today to gain new scientific insights. Interesting facts about paleoneurology and how interdisciplinary techniques have made it possible to draw conclusions about the evolution and physiology of the brains of extinct species and how to study the dead within the living can be read in this article.
de Sousa AA, Beaudet A, Calvey T, Bardo A, Benoit J, Charvet CJ, Dehay C, Gómez-Robles A, Gunz P, Heuer K, van den Heuvel MP, Hurst S, Lauters P, Reed D, Salagnon M, Sherwood CC, Ströckens F, Tawane M, Todorov OS, Toro R, Wei Y. From fossils to mind (2023), Commun Biol 2023; 6(1), https://doi.org/10.1038/s42003-023-04803-4
All life processes on our earth depend on the energy of sunlight. Light enables humans and animals to perceive their environment in colour and to orient themselves. But not only that - it also regulates their day-night rhythm and all related activities. In plants, light forms the basis for growth and development.
What role does light play in photosynthesis, the process that sustains life on our planet? How do animals perceive the world depending on the light environment in which they live? How can light control nerve cells and thus help us better understand how our memory works?
The event continues the series of Germany-wide symposia of the Hector Fellow Academy (HFA). Here, renowned experts present current research topics in a generally understandable way and discuss visions for the future. The HFA is a young science academy that promotes interdisciplinary cutting-edge research in MINT (mathematics, informatics, natural science and technology), psychology and medicine.
Here you can find further information about the programme
Langenbeck-Virchow-Haus, Luisenstraße 58/59, 10117 Berlin
You will receive the access data by e-mail.
Admission is free. The event will be held in German/English. Simultaneous translation will be provided.
Register now for the symposium "Light in Biology"! https://express.converia.de/frontend/index.php?sub=1188
On 20. June 2023, the Vogt archive welcomed guests from Augustana College, Illinois, USA. The course of twelve students, led by Philosopher Heidi Storl and Neuroscientist Ian Harrington, also visited Forschungszentrum Jülich, in particular the Institute of Neuroscience and Medicine and the Jülich Supercomputing Center.
Introductions to the two scientific archives were given by institute director Katrin Amunts and archivist Caroline Laperrouze (C. u. O. Vogt Institute for Brain Science at UKD) as well as Fabio de Sio and Ulrich Koppitz (Eccles-Archive, Institute for the History, Philosophy and Ethics of Medicine at HHU).
Thank you for the visit and the interesting discussions!
A key challenge in neuroscience is to understand how the brain can adapt to a changing world, even with a relatively static anatomy. The way the brain’s areas are structurally and functionally related to each other – its connectivity – is a key component. In order to explain its dynamics and functions, we also need to add another piece to the puzzle: receptors. Now, a new mapping by Human Brain Project (HBP) researchers from the Forschungszentrum Jülich (Germany) and Heinrich-Heine-University Düsseldorf (Germany), in collaboration with scientists from the University of Bristol (UK), New York University (USA), Child Mind Institute (USA), and University of Paris Cité (France) made advances on our understanding of the distribution of receptors across the brain.
The findings were published in Nature Neuroscience, and the data is now freely available to the neuroscientific community via the HBP’s EBRAINS infrastructure.
The HBP team used autoradiography to analyse the density of receptors for neurotransmitters on very thin in vitro brain sections. They measured the density of 14 neurotransmitter receptor types in 109 areas of the macaque cortex and this data was integrated with multiple structural parameters into neuroimaging templates.
Receptors are key molecules in signal transmission in the brain. Within a neuron, information transmission occurs via electric signals along the axon. But transfer of information between neurons usually requires the release of molecules called neurotransmitters into the extracellular space and their binding to receptors on the target neuron.
The HBP researchers have uncovered a primary and a secondary gradient of receptor expression per neuron. In other words, they mapped receptor densities across the cortex and were able to identify two main arrangements, shedding light on the links between molecular and neuron organization of the cortex. “These two major axes of receptor organisation in the macaque cortex align with two different functional systems, namely the sensory-cognitive and the external-internal cognition networks. This is the first time that such an association has been described,” explains Nicola Palomero-Gallagher, researcher at the Forschungszentrum Jülich and senior author of the paper.
In their study, the researchers integrated the new neurotransmitter receptor data with multiple layers of anatomical and functional data onto a common cortical space within the cortical surface of Yerkes19, a frequently used non-human primate template. Few studies so far had integrated in vitro anatomy and in vivo imaging of the macaque brain. Creating openly-accessible maps of receptor expression across the cortex that integrate neuroimaging data, such as what was done by the HBP team, could speed up translation across species.
“It is being made freely available to the neuroscientific community so that they can be used by other computational neuroscientists aiming to create other biologically informed models,” Palomero-Gallagher says. Part of the data generated for this study has already been implemented in a computational model of how dopamine gates information into the frontoparietal working-memory network.
Text by Helen Mendes
Gradients of neurotransmitter receptor expression in the macaque cortex
Sean Froudist-Walsh, Ting Xu, Meiqi Niu, Lucija Rapan, Ling Zhao, Daniel S. Margulies, Karl Zilles, Xiao-Jing Wang, Nicola Palomero-Gallagher. Nature Neuroscience. 19 June 2023. https://www.nature.com/articles/s41593-023-01351-2
Today our doctoral student Ariane Bruno successfully defended her dissertation at the Medical Faculty of Heinrich Heine University Düsseldorf. An incredible achievement, a lot of diligence, and the result of hard work.
We are very proud of you!
Congrats from the whole team of the C.&O. Vogt Institute of Brain Research!
Scientific Symposium | lab tours | exhibition | reception
From September 12 - 13, 2023, the Human Brain Project will celebrate its successful conclusion with a scientific symposium at Forschungszentrum Julich. In addition to the international project partners, representatives from politics and the media are cordially invited to attend.
In short presentations, researchers from the Human Brain Project will highlight the project’s achievements. The symposium will be accompanied by scientific exhibits, an impressive picture gallery and hands on trainings. In guided tours guests can explore the laboratories and facilities of Forschungszentrum Julich and get insights into the practical work behind the Human Brain Project.
For more information, please click here: https://www.humanbrainproject.eu/en/hbp-final-event/
Congratulations to our PhD student Serap Kurutas on her doctorate! Yesterday, Serap successfully defended her dissertation at the Medical Faculty of the Heinrich Heine University Düsseldorf. Prof. Dr. Katrin Amunts, PD Dr. Christina Herold and PD Dr. Julia Mehlhorn and both teams from the Cécile & Oskar Vogt Institute of Brain Research and Anatomy I at University Hospital Düsseldorf are very proud of you, Doctor Kurutas! Congrats from all of us!
Our Master's program Translational Neuroscience at HHU Düsseldorf is open for applications!
We are looking forward to your application on https://digstu.hhu.de/qisserver/pages/cs/sys/portal/hisinoneStartPage.faces
Application Deadline on 15th July 2023
Further infomation regarding the program can be found on our website https://www.translationalneuroscience.hhu.de/
Congratulations to our PhD student Saruka Devakuruparan on her doctorate at the Medical Faculty of Heinrich-Heine-University Düsseldorf. We are very proud of you and wish you all the best and every success on your further way!
We are looking for subjects for the Pupillox study - a computer-based behavioral study to investigate pupil dilation during transcutaneous vagus nerve stimulation.
The aim of the study is to investigate whether transcutaneous ("through the skin") vagus nerve stimulation (tVNS) leads to changes in pupil diameter. tVNS is a safe, non-invasive procedure in which the vagus nerve is stimulated through the skin of the left ear. It involves placing two small electrodes in two locations on your left ear, through which small amounts of electrical current flow. The electrode gel is applied to the inner ear only.
Further information about the study and registration can be found here.
The Clinical Neuroanatomy group of the Institute of Neuroscience and Medicine at Research Centre Jülich is looking for patients as well as healthy control subjects for research on Ataxia & Parkinson's Syndrome.
If you are interested in one of the mentioned studies, please contact the respective study contact person or send an email to email@example.com. Please include the study name, the study you are interested in, your name and phone number. You will then be called back promptly by the respective contact person.
Further information about the study can be found here.
Congratulations on passing the doctoral exam! Last week our PhD student Kimberley Lothmann successfully defended her dissertation. We are very happy about another successful graduation at our institute. Congrats from all of us!
We are very proud of you, Doctor Lothmann!
The gap in our team is huge. The memory of you remains alive in our hearts.
* 9th January 1961 ✝ 24th December 2022
We are deeply saddened by the death of our dear colleague who died much too soon. With Ulrich Opfermann, we lose an always helpful, friendly and committed employee. For more than 25 years, Uli was not only a medical-technical employee in our laboratory, but also responsible for the care of the Vogt archive and our collections, he was our house and court photographer and the good soul of the institute.
Our sincere condolences and deepest sympathy are with Uli's family.
We will always keep you in good memory and never forget your words: "Please smile".
Your colleagues of the Cécile & Oskar Vogt Institute of Brain Research
For the reception in the new Vogt Archive in the Himmelgeisterstraße on the 10th of January 2023, employees of the C.&O. Vogt Institute of Brain Research, representatives of the Medical Faculty, the Institute of the History, Philosophy and Ethics of Medicine, the Gesellschaft von Freunden und Förderern der Heinrich-Heine-Universität e.V as well as the members of the Board of Trustees and donors of the Cécile and Oskar Vogt Foundation came together. It was the kick-off for the digitization and relocation project of the estate and brain section collection of the research couple Cécile and Oskar Vogt. Many thanks to all participants who made this evening an impressive event. Especially to our speakers for their warm greetings, in particular to our Institute Director Prof. Dr. Amunts, to Prof. Dr. Nikolai Klöcker, Dean of the Medical Faculty, to Prof. Dr. Heiner Fangerau, Vice Dean for Strategic Development, to Mr. Eduard Dörrenberg, President of the Gesellschaft von Freunden und Förderern der Heinrich-Heine-Universität e.V. (GFFU) and to our guest of honor Prof. Dr. Rita Süssmuth. In the upcoming months, the Vogt Collection will be successively moved to its new location, digitized. Thus much easier access to this historical research material will be provided. It will help to complete our brain mapping and integrate the research results of more than six decades from the late 19th century into the modern brain atlases of the 21st century.
The Human Brain Project (HBP) is delighted to announce that registration for the HBP Summit 2023 is open. The event will take place at the Palais du Pharo in Marseille, France, from March 28-31, 2023.
Register before the early bird deadline on 2 February to benefit from a reduced registration fee! Click here to register.
Would you like to present your research at the HBP Summit? Make sure to submit your poster abstract! Two winners will have the opportunity to present their research to the audience in a 10-minute plenary talk. Submit your abstract before 2 February here.
A selection of satellite events - covering topics such as simulation, atlasing, and data analytics - will take place on 27 March 2023 at the Palais du Pharo as part of the Human Brain Project Summit 2023. You can find a preliminary list of satellite events in the programme here. Please note that you will have to register separately for each satellite event you wish to attend.
Please find here further information.
Oskar and Cécile Vogt were early pioneers in mapping the brain. In the six decades of their work, they made significant contributions to the understanding of brain organization and to the development of brain research as a science. The C.&O. Vogt Archive contains the extensive estate of the research couple.
To mark the start of the digitization and relocation of the Vogt Archive, brain researcher and institute director Prof. Katrin Amunts invites to a kick-off meeting in the new building in Düsseldorf's Himmelgeisterstraße. Invited are the staff of the C.&O. Vogt Institute of Brain Research, representatives of the Medical Faculty and the Institute of History, Philiosophy and Ethics of Medicine, as well as the Gesellschaft von Freunden und Förderern der Heinrich-Heine-Universität e.V., and the members of the Board of Trustees and donors of the Cécile and Oskar Vogt Foundation.
The Cécile and Oskar Vogt Institute of Brain Research at UKD and HHU is in the tradition of the research conducted by the Vogts and focuses on the question of the basic organizational principles and functions of the human brain, in particular the cerebral cortex and its dependence on various internal and external influences.
Tuesday, January 10, 2023 at 4 PM
Location: Himmelgeister Straße 103-105 in 40225 Düsseldorf
Contact: Caroline Laperrouze, scientific archivist (firstname.lastname@example.org)
A successful research year 2022 comes to an end for our scientists at the Cécile & Oskar Vogt Institute of Brain Research at University Hospital Düsseldorf and Institute for Neurosciences and Medicine (INM-1) at Forschungszentrum Jülich. Many thanks to everyone for the first-class research projects, collaborations, and publications in the renowned scientific journals 2022.
We wish you a Merry Christmas and a Happy New Year 2023.
Ukrainian brain researcher Nataliia Fedorchenko has been accepted as an associated PhD candidate at the Max Planck School of Cognition (MPSCog). She will carry out her PhD under the supervision of MPSCog faculty member Katrin Amunts at the Cécile and Oskar Vogt Institute of Brain Research at Heinrich Heine University Düsseldorf.
Fedorchenko joined Amunts’ team earlier this year after fleeing Kyiv, where she had recently started a PhD focused on stroke after Covid-19 infections. The trained neurologist has a special interest in stroke, speech deficits and language cognition.
In Jülich and Düsseldorf, Fedorchenko currently works within the scientific coordination team of the Human Brain Project, where she is mainly responsible for the position paper ‘The coming decade of digital brain research – A vision for neuroscience at the interaction of technology and computing’. She is also involved in the digitalization of the Vogt brain collection at the Cecile & Oskar Vogt Institute.
In January 2023, Fedorchenko will commence her new PhD project studying the Broca's region of the human brain, which is involved in language processing and plays a major role in the clinical context, e.g., in aphasia.
To unveil the connectivity of different areas within the brain region, Fedorchenko will employ an advanced imaging technique called 3D Polarized Light Imaging, which has been developed by Amunts’ team. Her aim is to achieve novel insights into the region’s organization that will eventually advance clinical applications.
Fedorchenko is one of four associated candidates who have been accepted this year to the highly competitive programme of the Max Planck School of Cognition. PhD students of the graduate school conduct research at world-renowned research institutions in Germany, the Netherlands and the UK. As an associated PhD candidate, Fedorchenko will join the Max Planck School for three years.
Fedorchenko is particularly excited about the interdisciplinary approach and the international network of brilliant scientists that the Max Planck School is offering. “Being part of the Max Planck School of Cognition is a unique opportunity to have access to high-level researchers and receive valuable feedback from other international students,” she says.
Read more about Nataliia Fedorchenko in the Helmholtz news:
The annual NeurIPS conference (Conference on Neural Information Processing Systems) is considered the world's most important forum for artificial intelligence, with participants from all over the world. Every year, competitions are held as part of the conference to select the best AI developments for various use cases.
In the category "Machine Learning for Physical and Life Sciences", Eric Upschulte, a member of the Big Data Analytics group at INM-1, placed one of the top spots. He reached the top ten among 443 participants in the "Cell Segmentation Competition". The researcher will now present his results at the conference in New Orleans, USA.
For the competition, participants submitted self-developed AI algorithms that automatically recognise cells in microscopy images. Such methods are becoming increasingly important in order to be able to deal efficiently with large data sets from research. At INM-1, the algorithms contribute to mapping the brain by quickly recognising and labelling individual neurons in large high-resolution scans.
The 36th Conference on Neural Information Processing Systems (NeurIPS) will take place from 28 November to 09 December 2022. More information about the competitions:
The multilevel Julich Brain Atlas developed by researchers in the Human Brain Project, could help in studying psychiatric and aging disorders by correlating brain networks with their underlying anatomical structure. By mapping microarchitecture with unprecedented levels of detail, the atlas allows for better understanding of brain connectivity and function. Researchers of the HBP have provided an overview of the Julich Brain Atlas in the journal Biological Psychiatry. The paper focuses on the cytoarchitecture and receptor architecture of the human brain, and how to apply the atlas in the field of psychiatric research.
Cytoarchitecture, the study of the distribution, density and morphology of cells in the nervous system, has a long standing history in brain mapping. Neuroscientists first noticed structural differences between areas of the cortex back in the late 1800s and started dividing it into distinct areas. The areas have been considered important correlates with brain function and dysfunction. In addition to the cellular architecture, the Julich Brain Atlas also includes maps of the distribution of receptors for the neurotransmitters which modulate brain activity. Neurotransmitter receptors differ not only between areas, but also between the different layers of an area and thus are closely related to its connectivity pattern, and relevant for its role in larger networks. Based on the data collected from post mortem brains, the atlas accounts for the naturally occurring variability between subjects by producing probabilistic maps in 3D spaces instead of the map of an individual brain only.
The Julich Brain Atlas is a “living” atlas that grows with new insights into the parcellation of the brain constantly being integrated. It is linked to other maps, e.g., coming from studies of fiber tracts in the living human brain. Such macroscopic and microscopic data are integrated in the HBP’s Multilevel Human Brain Atlas, which is openly accessible on the EBRAINS digital research infrastructure through the siibra software tool suite.
The researchers listed recent use cases of the tools in different peer-reviewed studies. Users can, for example, analyse and share high-resolution imaging data and compare it with fMRI datasets. They can look into the cytoarchitecture of a certain region and its connectivity, both within itself and with other regions. With a special tool called JuGEX, the maps can be linked to gene expression data from the Allen Brain Atlas, allowing deep multimodal investigations: For example, using the Julich Brain Atlas, researchers had identified new brain areas that play a role in major depressive disorder. Neuroimaging data from patients revealed area-specific changes in gray matter volume and activation. With JuGEX, these findings were further linked to local differences in the expression of several candidate genes for major depressive disorder. From large population studies, individual, personalised maps of aging or dysfunction can also be extracted to provide diagnostic tools for dementia.
Text by Roberto Inchingolo
Reference: Daniel Zachlod, Nicola Palomero-Gallagher, Timo Dickscheid, Katrin Amunts (2022). Mapping cyto- and receptor architectonics to understand brain function and connectivity. Biological Psychiatry, DOI: doi.org/10.1016/j.biopsych.2022.09.014
At the beginning of November, the Joint Science Conference (GWK) decided to include eight more consortia in a third round of funding for the National Research Data Infrastructure (NFDI). This means that the NFDI4BIOIMAGE consortium will also be funded for the next five years. At INM-1, Prof. Timo Dickscheid's research group "Big Data Analytics" is involved in the consortium. https://www.fz-juelich.de/en/inm/inm-1/research/big-data-analytics
The National Research Data Infrastructure NFDI is an initiative to establish an infrastructure framework for research data management in Germany. The aim is to develop reliable central standards and infrastructures for the storage, networking and use of data from science and research. This should enable data to be used across disciplinary and institutional boundaries.
The NFDI4BIOIMAGE initiative focuses on microscopy and biological image acquisition and processing ("bioimaging"). It is precisely in these areas that huge amounts of research data accumulate. For many disciplines in the life sciences that rely on bioimaging, adequate data management is indispensable, but it has not yet been sufficiently realised.
NFDI4BIOIMAGE aims to create solutions so that bioimaging data can be shared and reused across disciplinary boundaries. This should enable the full information content of the data to be exploited. They should also be available for re-analysis in order to gain new insights - possibly beyond the original research question.
To understand how our brain works, there is no getting around investigating how different brain regions are connected with each other by nerve fibres. In the most recent issue of Science, researchers of the Human Brain Project (HBP) review the current state of the field, provide insights on how the brain’s connectome is structured on different spatial scales – from the molecular and cellular to the macro level – and evaluate existing methods and future requirements for understanding the connectome’s complex organisation.
Read the full article here.
Markus Axer & Katrin Amunts. Scale matter: The nested human connectome. Science, 3 Nov 2022. Vol 378, Issue 6619, pp. 500-504, DOI: 10.1126/science.abq2599
Atlasing in rodents:
In the same issue, HBP Infrastructure Director Jan Bjaalie (University of Oslo) and principal investigator Trygve B. Leergaard review brain data integration in rodent atlases:
Leergaard & Bjaalie. Atlas-based data integration for mapping the connections and architecture of the brain. Science, 3 Nov 2022. Vol 378, Issue 6619, pp. 488-492, DOI: 10.1126/science.abq2594
Tel.: +49 2461 61 96860
A new field of science has been emerging at the intersection of neuroscience and high-performance computing - this is the takeaway from the 2022 BrainComp conference, which took place in Cetraro, Italy from the 19th to the 22nd of September. The meeting, which featured international experts in brain mapping, machine learning, simulation, research infrastructures, neuro-derived hardware, neuroethics and more, strengthened the current collaborations in this emerging field and forged new ones.
Now in its 5th edition, BrainComp first started in 2013 and is jointly organised by the Human Brain Project and the EBRAINS digital research infrastructure, University of Calabria in Italy, the Heinrich Heine University of Düsseldorf and the Forschungszentrum Jülich in Germany. It is attended by researchers from inside and outside the Human Brain Project. This year was dedicated to the computational challenges of brain connectivity. The brain is the most complex system in the observable universe due to the tight connections between areas down to the wiring of the individual neurons: decoding this complexity through neuroscientific and computing advances benefits both fields.
Hosted by the organising committee of Katrin Amunts, Scientific Research Director of the HBP, Thomas Lippert, Leader of EBRAINS Computing Services from the Juelich Supercomputing Centre and Lucio Grandinetti from the University of Calabria, the sessions included a variety of topics over four days.
Please find here further information.
Text: Roberto Inchingolo
Congratulations on passing the doctoral exam! We are always interested in the continuing education and personal development of our employees. We are very happy and proud to announce that Dr. Kai Kiwitz has received his doctoral degree yesterday. Congrats from all of us!
We are very proud of you, Doctor Kiwitz!
We are very proud to announce that our dear colleague Prof. Dr. Nicola Palomero-Gallagher had been awarded the title of an Extraordinary Professorship at the Heinrich-Heine-University Düsseldorf. On October, 18th, 2022 she received her certificate of appointment from Prof. Dr. Heiner Fangerau, the vice dean for strategic development of the HHU.
On 12 October 2022, HBP Scientific Director Katrin Amunts and Tommaso Calarco, chair of the Quantum Community Network of the Quantum Flagship, presented two special pieces from Forschungszentrum Jülich to the European Commission in Brussels: an enlarged image of human brain fibers and a true-to-scale replica of the quantum computer "OpenSuperQ". It had been an inspiring meeting about the EU Flagships Human Brain Project and Quantum Flagship with the EC’s DG CNECT.
Further information can be found on: https://www.humanbrainproject.eu/en/follow-hbp/news/2022/10/13/hbp-image-human-brain-network-exhibited-offices-european-commission/
From the current research of our scientist Christina Herold there are again interesting facts to read. This time it's about the anatomy, biochemistry and connectivity of cluster N and the hippocampal formation in a migratory bird (garden warbler). The data suggest that the densocellular hyperpallium may provide a central relay station for the transmission of magnetic compass information to the hippocampal formation, where it may be integrated with other navigational cues in nocturnal songbirds. The work was done in collaboration with Dr. Dominik Heyers of the University of Oldenburg. More information can be found here.
Heyers D, Musielak I, Haase K, Herold C, Bolte P, Güntürkün O, Mouritsen H, Morphology, biochemistry and connectivity of Cluster N and the hippocampal formation in a migratory bird, 2022, Brain Structure and Function, DOI:https://doi.org/10.1007/s00429-022-02566-y
In August 2022, Katrin Amunts from Forschungszentrum Jülich and Alan Evans from McGill University in Canada presented AI applications in brain mapping to German Federal Chancellor Olaf Scholz, Vice Chancellor Robert Habeck and a delegation of high-ranking industry representatives during their visit of the Institut québécois d'intelligence artificielle (Mila) in Montreal.
The successful collaboration between the research teams of Amunts add Evans is carried out under the funding umbrella of the Helmholtz International BigBrain Analystics & Learning Laboratory (HIBALL). In 2013, the neuroscientists jointly presented the BigBrain in the journal Science - a three-dimensional reconstruction of a single human brain with uniquely high resolution. HIBALL takes the successful collaboration to the next level by strengthening the use and joint development of the latest technologies in artificial intelligence (AI) and high-performance computing (HPC) for neuroscience.
In close partnership with the European Human Brain Project and the Canadian Healthy Brains, Healthy Lives programme, HIBALL is building new transatlantic computing platforms to share big data and workflows between Canada and Germany, enabling collaboration across national, structural and technical boundaries.
During the visit to Canada, the German Chancellor praised the great progress made, especially in AI, which is an important field both for Germany as a science location and for the future of the German economy.
We would like to draw your attention to the Hector Research Career Development Award. Since 2020, this award is given by the Hector Fellow Academy to support the career of scientists in the phase between postdoc and professorship. The award is aimed at:
- W1 junior professors (with and without tenure track)
- Junior research group leaders in comparable positions in natural sciences, engineering, medicine or psychology
Further requirements for an application are an excellent doctorate, which has been completed no longer than seven years ago, a position at a German university or a comparable research institution, as well as a substantive or formal qualification to supervise doctoral students. The award will be given to 3 scientists, of whom at least 50 percent will be female. It is endowed with 25,000 € and includes additional funding for a doctoral position.
The application period is from September 1 to October 30, 2022. For more information, please visit the Hector Fellow Academy website.
The Hector Fellow Academy looks forward to receiving your application!
Very interesting findings from recent research by our scientist Felix Ströckens and colleagues. Avian neurons consume three times less glucose than mammalian neurons. The article has just been published in the journal Current Biology. More information can be found here.
von Eugen K, Endepols H, Drzezga A, Neumaier B, Güntürkün O, Backes H, Ströckens F, Avian neurons consume three times less glucose than mammalian neurons, 2022, Current Biology, DOI:https://doi.org/10.1016/j.cub.2022.07.070
The application of the Max Planck School of Cognition is now open until December 1st 2022. The program starts each year on September 1st.
The Max Planck School of Cognition invites applications from exceedingly bright students with strong academic experience in areas related to cognition such as artificial intelligence, biology, (cognitive) neuroscience, genetics, linguistics, mathematics, neurobiology, neuroimaging, neurology, neurophysics, philosophy, physics, psychiatry, and psychology.
Further information regarding the application procedure can be found on their website: https://cognition.maxplanckschools.org/en/application
They also accept applications for the new Clinician Scientist Program now: https://cognition.maxplanckschools.org/en/csp
Congratulations to our Master's student Alexey Chervonnyy for successfully completing his Master of Science in Translational Neuroscience. Great achievement! We look forward to his doctoral studies at the C.&O. Vogt Institute of Brain Research.
The human dorsolateral prefrontal cortex is involved in cognitive control including attention selection, working memory, decision making and planning of actions. Changes in this brain region are suspected to play a role in schizophrenia, obsessive-compulsive disorder, depression and bipolar disorder, making it an important research target. A research team based at the Institute of Neuroscience and Medicine of Forschungszentrum Jülich and the C. & O. Vogt Institute of Brain Research at Heinrich Heine University Düsseldorf now provide detailed, three-dimensional maps of four new areas of the brain region.
In order to identify the borders between brain areas, the researchers statistically analysed the distribution of cells (the cytoarchitecture) in 10 post mortem human brains. After reconstructing the mapped areas in 3D, the researchers superimposed the maps of the 10 different brains and generated probability maps that reflect how much the localization and size of each area varies among individuals.
High inter-subject variability has been a major challenge for prior attempts to map this brain region leading to considerable discrepancies in pre-existing maps and inconclusive information making it very difficult to understand the specific involvement of individual brain areas in the different cognitive functions. The new probabilistic maps account for the variability between individuals and can be directly superimposed with datasets from functional studies in order to directly correlate structure and function of the areas.
When comparing the brains of female and male tissue donors, the researchers found that the relative volumes of two of the newly identified areas were significantly larger in female than in male brains. This finding may be related to sex differences in cognitive function and behaviour as well as in the prevalence and symptoms of associated brain diseases.
The maps are being integrated into the Julich Brain Atlas that is openly accessible via the Human Brain Project’s research infrastructure EBRAINS.
Original publication: Bruno A, Bludau S, Mohlberg H and Amunts K (2022) Cytoarchitecture, intersubject variability, and 3D mapping of four new areas of the human anterior prefrontal cortex. Front. Neuroanat. 16:915877. doi: 10.3389/fnana.2022.915877
Brain and Evolution 2022 summer school
During the last week, the ‘Brain and Evolution 2022’ summer school took place in one of the most exciting cities on this planet: Istanbul, Turkey. Supported by the Erasmus+ Program of the European Union and organized by scientists from Koç University Istanbul, Heinrich-Heine University Düsseldorf, Ruhr-University Bochum and Medical School Hamburg, students, young academics and senior scientist from different German and Turkish labs had the opportunity to discuss their projects, plan new experiments and intensify Turkish-German cooperation. From mammalian neuroanatomy to song bird behavior and crow brains (and many other research areas) the summer school covered a wide range of fascinating topics within the field of comparative neuroscience and brain evolution. In the marvelous environment of Koç University, students from all different fields of neuroscience took the chance to approach and interact with experienced senior scientists and initialized first contacts for collaboration and cooperation projects. Given the enthusiasm of both participating students and scientists, we are certain that these projects will prosper and we are looking forward to further cooperations and activities with our old and new friends from Turkey and Germany! Author: Dr. Felix Ströckens
Behind these three words in the CV of brain researcher Nataliia Fedorchenko lie war and flight, and the hope that she will be able to use her knowledge, which she is now contributing to the Human Brain Project at the Forschungszentrum Jülich, to help rebuild Ukraine.
Further information can be found on the following website: https://www.helmholtz.de/en/newsroom/article/leave-of-absence/
A team of researchers from the C. and O. Vogt Institute for Brain Research at the University of Düsseldorf and the Institute of Neuroscience and Medicine (INM-1) at Forschungszentrum Jülich have identified seven new areas of the human insular cortex, a region of the brain that is involved in a wide variety of functions, including self-awareness, cognition, motor control, sensory and emotional processing. All newly detected areas are now available as 3D probability maps in the Julich Brain Atlas, and can be openly accessed via the Human Brain Project’s EBRAINS infrastructure. Their findings, published in NeuroImage, provide new insights into the structural organisation of this complex and multifunctional region of the human neocortex.
The human insular cortex, or simply “insula”, has gained the attention from researchers since the early 19th century. But a 3D cytoarchitectonic map of the insula that could be linked to neuroimaging studies addressing different cognitive tasks was thus far not available.
The HBP team analysed images of the middle posterior and dorsal anterior insula of ten human brains and used statistical mapping to calculate 3D-probability maps of seven new areas. The probability maps reflect the interindividual variability and localisation of the areas in a three-dimensional space.
Brain areas with differences in their cytoarchitecture - or the organisation of their cellular composition - also likely differ in function. Based on this hypothesis, the researchers aimed to better understand the differences in the microstructure of the insula, and to identify areas that may correlate with its diverse and complex multifunctionality.
The team found that the microstructure of the insula has a remarkable diversity and a broad range of cytoarchitectonic features, which might be the basis for the complex functional organisation in this brain region.
A cluster analysis based on cytoarchitecture resulted in the identification of three superordinate microstructural clusters in the insular cortex. The clusters revealed significant differences in the microstructure of the anterior and posterior insula, reflecting systematic functional differences between both entities.
The new maps are now openly available in the Human Brain Project’s Multilevel Human Brain Atlas on EBRAINS to support future studies addressing relations between structure and function in the human insula.
Quabs J, Caspers S, Schöne C, Mohlberg H, Bludau S, Dickscheid T, Amunts K (2022).
Cytoarchitecture, probability maps and segregation of the human insula,
NeuroImage, Volume 260, 119453, ISSN 1053-8119, https://doi.org/10.1016/j.neuroimage.2022.119453.
Alexey Chervonnyy has been awarded a PhD Scholarship from the Hector Fellow Academy. The scholarship, awarded after a multi-stage selection process, will fund a three-year research project at the C. and O. Vogt Institute for Brain Research in Düsseldorf under the supervision of Hector Fellow Katrin Amunts. Chervonnyy will investigate the structure of the human hypothalamus, a part of the brain that plays a key role in regulating neuroendocrine, behavioural and autonomic processes essential to life, such as circadian rhythms, metabolic processes, sleep and body temperature.
“It is a great honour for me to be part of this prestigious programme,” says Chervonnyy, “and I also understand that it comes with a responsibility – which I am more than happy to accept.”
Alexey Chervonnyy has carried out an MSc in Translational Neuroscience at Heinrich Heine University Düsseldorf and holds a Diploma in Clinical Psychology from Lomonosov Moscow State University. “Alexey is an exceptionally bright student, who has proven his skills and his commitment throughout his MSc studies,” says Katrin Amunts.
During his doctoral research, Chervonnyy will employ an advanced deep-learning mapping tool to analyse the cytoarchitecture of the hypothalamus – the distribution, density and morphology of cells. He will generate a high-resolution, 3D-reconstructed histological model of hypothalamic nuclei as well as probabilistic maps that reflect interindividual variability of brain areas.
The produced maps will be integrated into the Julich Brain Atlas and made publicly available via the Human Brain Project’s research infrastructure EBRAINS. The Julich Brain Atlas has become a modern-day reference map of the brain for the neuroimaging community and its high-precision data serves clinical researchers to improve medical interventions.
“I am very excited to start this important project and work together with Prof. Katrin Amunts – a leading expert in the field of neuroscience,” says Chervonnyy. “The Hector Fellow Academy creates a bridge between generations fostering exchange between young scientists and senior researchers,” he adds.
In addition to funding the doctoral research, the Hector Fellow Academy is offering young researchers various training programmes to improve communication and management skills, which Chervonnyy stresses will have a great impact on his future career.
We are excited to announce the launch of the new Julich Brain Atlas website. The page presents the concept and research behind the human brain atlas developed by teams at the Institute of Neuroscience Medicine (INM-1) at Forschungszentrum Jülich and the Cécile and Oscar Vogt Institute for Brain Research in Düsseldorf.
The Julich Brain Atlas is the result of more than a quarter of a century of research and has become a modern-day reference of the brain for the neuroimaging community. The atlas contains cytoarchitectonic maps of the human brain in high resolution and comprises maps of more brain areas than ever identified before. It shows the brain’s cellular architecture in a three-dimensional space and reflects variability between individual brains. Various neuroscientific data from different levels can be systematically integrated and analyzed in the atlas – a kind of Google Earth for the brain.
“With the Julich Brain Atlas, we want to provide a tool for scientists around the world to better understand the brain and enable clinicians to plan medical intervention more precisely,” says Katrin Amunts, head of the Julich Brain Atlas and Director of the C. and O. Vogt Institute of Brain Research and the Institute of Neuroscience and Medicine at Forschungszentrum Jülich.
The new website provides deeper insights into the work that has gone into building the Julich Brain Atlas and the different types of data it comprises – from cytoarchitectonic maps over neurotransmitter receptor densities to fibre architecture. The data of the atlas is made openly available to the scientific community via the Human Brain Project’s research infrastructure EBRAINS.
Prof. Katrin Amunts has received the Hector Science Award 2021. The prestigious prize of 150,000 Euro honours professors from German universities and research institutions for outstanding research achievements, dedication to the education and support of young scientists and contributions to advancing their disciplines and institutions. The award was presented during a virtual award ceremony on 28 January.
You will find further information here.
A video of the award winner can be found here.
In the latest issue of Science, Katrin Amunts and Thomas Lippert explain how advances in neuroscience demand high-performance computing technology and will ultimately need exascale computing power.
Please find here the press release.
The full dataset of the Julich-Brain probabilistic maps has been published and can be freely downloaded. The data package comprises 148 probability maps in a three-dimensional reference space.
The Human Brain Project Summit 2021 will provide an open forum for hundreds of researchers, as well as policy makers, media and public, to discuss exciting scientific results, the latest developments in the project, and the cutting-edge services and tools available on EBRAINS.
The four-day event will kick off with the European Brain Summit taking place on-site in the heart of Brussels, followed by an internal day of HBP meetings carried out online, and finishes with the two-day online scientific conference of the HBP.
You can register here ➡ https://summit2021.humanbrainproject.eu/home/tickets
Find our programme here ➡ https://summit2021-humanbrainproject.eu/programme
We look forward to hosting you for a lively scientific discussion and exchange of ideas around groundbreaking brain science!
Further information can be found here.
The Fourth Vogt Brodmann Symposium “The human brain and its variability”Dedicated to the memory of Karl Zilles will take place on September 15 and 16, 2022 in Düsseldorf.
A deeper understanding of the organization of the human brain and its variability is more relevant today than ever before. Modern methods of machine learning and high-performance computing in combination with neuroimaging open up unprecedented possibilities in the fields of brain mapping and medicine. The symposium will provide a forum for the latest research on the organizational principles of the human brain and its variability from different perspectives. The list of invited speakers includes Carmen Cavada, Alan Evans, Angela Friederici, Onur Güntürkün, Gitte Moos Knudsen, Aleksandar Maliković, Gottfried Schlaug, Michel Thiebaut de Schotten, Arthur Toga and Andreas Wree.