Clinical relevance and anatomical basis of electrophysiological responses evoked by deep brain stimulation

Deep brain stimulation (DBS) is an established symptomatic therapy for Parkinson’s disease (PD) and Essential Tremor (ET). Although DBS is a routinely used therapy, its mechanism of action is poorly understood. One hypothesis states that not only the subcortical DBS target but also remote, connected brain areas need to be modulated to achieve optimal clinical benefit. One way to identify these remote targets is to localize electrophysiological responses evoked by single DBS pulses using magnetoencephalography. This project utilizes this approach to investigate the link between the clinical effects of DBS and functional as well as structural connectivity between the subcortical target site and remote cortical areas. The project is funded by Forschungskommission der Medizinischen Fakultät der Heinrich-Heine-Universität Düsseldorf.

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