Liste der Veröffentlichungen / Publications:

2023
  • Diminished Interleukin-7 receptor expression on T-cell subsets in tuberculosis patients. Acheampong I, Minadzi D, Adankwah E, Aniagyei W, Vivekanandan MM, Yeboah A, Arthur JF, Lamptey M, Abass MK, Kumbel F, Osei-Yeboah F, Gawusu A, Laing EF, Batsa Debrah L, Owusu DO, Debrah A, Mayatepek E, Seyfarth J, Phillips RO, Jacobsen M. Human Immunology. Pubmed.

  • Monocyte pathology in human tuberculosis is due to plasma milieu changes and aberrant STAT signalling. Ahor HS, Schulte R, Adankwah E, Harelimana JD, Minadzi D, Acheampong I, Vivekanandan MM, Aniagyei W, Yeboah A, Arthur JF, Lamptey M, Abass MK, Kumbel F, Osei-Yeboah F, Gawusu A, Debrah LB, Owusu DO, Debrah A, Mayatepek E, Seyfarth J, Phillips RO, Jacobsen M.  Immunology. Pubmed.

  • Memory B-cells are enriched in the blood of patients with acute Buruli ulcer disease: a prospective observational study. Adjei JK, Aniagyei W, Adankwah E, Seyfarth J, Mayatepek E, Berko DA, Ackam N, Annani-Akollor ME, Sakyi SA, Amoako YA, Owusu D, Jacobsen M, Phillips RO. BMC Infectious Diseases. Pubmed.

  • BCG-Vaccinated Children with Contact to Tuberculosis Patients Show Delayed Conversion of Mycobacterium tuberculosis-Specific IFN-γ Release. Owusu DO, Adankwah E, Aniagyei W, Acheampong I, Minadzi D, Yeboah A, Arthur JF, Lamptey M, Vivekanandan MM, Abass MK, Kumbel F, Osei-Yeboah F, Gawusu A, Batsa Debrah L, Debrah A, Mayatepek E, Seyfarth J, Phillips RO, Jacobsen M. Vaccines (Basel). Pubmed.

  • Impaired T-cell response to phytohemagglutinin (PHA) in tuberculosis patients is associated with high IL-6 plasma levels and normalizes early during anti-mycobacterial treatment. Vivekanandan MM, Adankwah E, Aniagyei W, Acheampong I, Minadzi D, Yeboah A, Arthur JF, Lamptey M, Abass MK, Kumbel F, Osei-Yeboah F, Gawusu A, Debrah LB, Owusu DO, Debrah A, Mayatepek E, Seyfarth J, Phillips RO, Jacobsen M. Infection. Pubmed.

2022
  • Plasma cytokine levels characterize disease pathogenesis and treatment response in tuberculosis patients. Vivekanandan MM, Adankwah E, Aniagyei W, Acheampong I, Yeboah A, Arthur JF, Lamptey MNK, Abass MK, Gawusu A, Kumbel F, Osei-Yeboah F, Debrah LB, Owusu DO, Debrah A, Mayatepek E, Seyfarth J, Phillips RO, Jacobsen M. INFECTION. Pubmed
  • Doxycycline treatment of Mansonella perstans infected individuals affects immune cell activation and causes long-term T-cell polarization.Aniagyei W, Adjei JK, Adankwah E, Seyfarth J, Mayatepek E, Berko DA, Sakyi SA, Debrah LB, Debrah AY, Hoerauf A, Owusu DO, Phillips RO, Jacobsen M. Doxycycline treatment of Mansonella perstans infected individuals affects immune cell activation and causes long-term T-cell polarization. CLINICAL INFECTIOUS DISEASES. Pubmed
  • Cytokine-induced transient monocyte IL-7Ra expression and the serum milieu in tuberculosis. Harelimana JD, Ahor HS, Benner B, Hellmuth S, Adankwah E, Minadzi D, Aniagyei W, Lamptey MNK, Arthur J, Yeboah A, Abass MK, Debrah LB, Owusu DO, Mayatepek E, Seyfarth J, Phillips RO, Jacobsen M.  EUROPEAN JOURNAL OF IMMUNOLOGY. Pubmed
  • PPE51 mediates uptake of trehalose across the mycomembrane of Mycobacterium tuberculosis. Babu Sait MR, Koliwer-Brandl H, Stewart JA, Swarts BM, Jacobsen M, Ioerger TR, Kalscheuer R. SCIENTIFIC REPORTS. Pubmed
  • Interleukin-7 and soluble Interleukin-7 receptor levels in type 1 diabetes - Impact of IL7RA polymorphisms, HLA risk genotypes and clinical features. Hoffmann M, Enczmann J, Balz V, Kummer S, Reinauer C, Döing C, Förtsch K, Welters A, Kohns Vasconcelos M, Mayatepek E, Meissner T, Jacobsen M, Seyfarth J. CLINICAL IMMUNOLOGY. Pubmed
2021
  • Interleukin-7-dependent nonclassical monocytes and CD40 expression are affected in children with type 1 diabetes. Hehenkamp P, Hoffmann M, Kummer S, Reinauer C, Döing C, Förtsch K, Enczmann J, Balz V, Mayatepek E, Meissner T, Jacobsen M, Seyfarth J. EUROPEAN JOURNAL OF IMMUNOLOGY. PubMed
  • CD5-expressing CD8+ T-cell subsets differ between children with type 1 diabetes and controls. Wadenpohl J, Seyfarth J, Hehenkamp P, Hoffmann M, Kummer S, Reinauer C, Döing C, Förtsch K, Mayatepek E, Meissner T, Jacobsen M. IMMUNOLOGY & CELL BIOLOGY. PubMed
  • Aberrant cytokine milieu and signaling affect immune cell phenotypes and functions in tuberculosis pathology: What can we learn from this phenomenon for application to inflammatory syndromes? Adankwah E, Seyfarth J, Phillips R, Jacobsen M. CELLULAR & MOLECULAR IMMUNOLOGY. PubMed
  • Lower IL-7 Receptor Expression of Monocytes Impairs Antimycobacterial Effector Functions in Patients with Tuberculosis. Adankwah E, Harelimana JD, Minadzi D, Aniagyei W, Abass MK, Batsa Debrah L, Owusu DO, Mayatepek E, Phillips RO, Jacobsen M. JOURNAL OF IMMUNOLOGY. PubMed
  • Immune response against tuberculosis and nontuberculous mycobacterial pulmonary disease in patients from Ghana. Adankwah E, Arthur RA, Minadzi D, Owusu DO, Phillips RO, Jacobsen M. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASES.PubMed
  • Machine learning algorithms to analyze novel immunodiagnostic tests for childhood tuberculosis. Meier N, Sutter TM, Jacobsen M, Ottenhoff THM, Vogt JE, Ritz N and the CITRUS study team. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. PubMed
  • Interleukin-6 and Mycobacterium tuberculosis dormancy antigens improve diagnosis of tuberculosis. Adankwah E, Nausch N, Minadzi D, Abass MK, Franken KLMC, Ottenhoff THM, Mayatepek E, Phillips RO, Jacobsen M. JOURNAL OF INFECTION. PubMed
2020
  • Suppressor of cytokine signalling 3 is crucial for interleukin-7 receptor re-expression after T-cell activation and interleukin-7 dependent proliferation. Güler A, Lopez Venegas M, Adankwah E, Mayatepek E, Nausch N, Jacobsen M. EUROPEAN JOURNAL OF IMMUNOLOGY. PubMed
  • CD27 expression of T-cells discriminates IGRA-negative TB patients from healthy contacts in Ghana. Adankwah E, Güler A, Mayatepek E, Phillips RO, Nausch N, Jacobsen M. MICROBES & INFECTION. PubMed
  • IL7RA genetic variants differentially affect IL-7Rα expression and alternative splicing: a role in autoimmune and infectious diseases? Lundtoft C, Seyfarth J, Jacobsen M. GENES AND IMMUNITY. PubMed
2019
  • Identification and validation of host biomarkers for leprosy: A step forward to establish point-of-care tests. Nausch N, Jacobsen M. EBIOMEDICINE. Pubmed
  • Suppressor of  Cytokine Signaling 3 is crucial for Interleukin-7 receptor re-expression after T-cell activation and Interleukin-7 dependent proliferation. Güler A, Lopez Venegas M, Adankwah E, Mayatepek E, Nausch N, Jacobsen M. EUROPEAN JOURNAL OF IMMUNOLOGY. PubMed
  • Type-1 diabetes onset age and sex differences between Ghanaian and German urban populations. Seyfarth J, Sarfo-Kantanka O, Rosenbauer J, Phillips RO, Jacobsen M. JOURNAL OF DIABETES. PubMed
  • CD27 expression of T-cells discriminates IGRA-negative TB patients from healthy contacts in Ghana. Adankwah E, Güler A, Mayatepek E, Phillips RO, Nausch N, Jacobsen M. MICROBES AND INFECTION. PubMed
  • Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana. Adankwah E, Lundtoft C, Güler A, Franken KLMC, Ottenhoff THM, Mayatepek E, Owusu-Dabo E, Phillips RO, Nausch N, Jacobsen M. FRONTIERS IN IMMUNOLOGY. PubMed
  • The Efficacy of Doxycycline Treatment on Mansonella perstans Infection: An Open-Label, Randomized Trial in Ghana. Batsa Debrah L, Phillips RO, Pfarr K, Klarmann-Schulz U, Opoku VS, Nausch N, Owusu W, Mubarik Y, Sander AL, Lämmer C, Ritter M, Layland LE, Jacobsen M, Debrah AY, Hoerauf A. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. PubMed
  • CD4T-Cells with high common γ chain expression and disturbed cytokine production are enriched in children with Type-1 Diabetes. Seyfarth J, Mütze N, Antony Cruz J, Kummer S, Reinauer C, Mayatepek E, Meissner T, Jacobsen M. FRONTIERS IN IMMUNOLOGY. PubMed
  • Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression characterize impaired T-cell functions in tuberculosis patients. HarlingK, AdankwahE, Güler A, Afum-Adjei Awuah A, Adu-Amoah L, Mayatepek E, Owusu-Dabo E, Nausch N, Jacobsen M. CELLULAR & MOLECULAR IMMUNOLOGY. PubMed
  • Higher Interleukin-7 serum concentrations in patients with cystic fibrosis correlate with impaired lung function. Seyfarth J, Sivagurunathan S, Ricken S, Weinreich G, Olbrich L, Taube C, Mayatepek E, Schramm D, Jacobsen M. JOURNAL OF CYSTIC FIBROSIS. PubMed

https://www.ncbi.nlm.nih.gov/pubmed/?term=30389600

2018
  • A Systematic Review on Novel Mycobacterium tuberculosis Antigens and Their Discriminatory Potential for the Diagnosis of Latent and Active Tuberculosis. Meier NR, Jacobsen M, Ottenhoff THM, Ritz N. FRONTIERS IN IMMUNOLOGY. PubMed
  • A proteomics approach for the identification of species-specific immunogenic proteins in the Mycobacterium abscessus complex. Steindor M, Nkwouano V, Stefanski A, Stuehler K, Ioerger TR, Bogumil D, Jacobsen M, Mackenzie CR, Kalscheuer R. MICROBES AND INFECTION. PubMed
  • An IL7RA exon 5 polymorphism is associated with impaired IL-7Rα splicing and protection against tuberculosis in Ghana. Lundtoft C, Awuah AA, Güler A, Harling K, Schaal H, Mayatepek E, Phillips RO, Nausch N, Owusu-Dabo E, Jacobsen M. GENES AND IMMUNITY. PubMed
  • Autoimmunity risk- and protection-associated IL7RA genetic variants differentially affect soluble and membrane IL-7Rα expression. Lundtoft C, Seyfarth J, Oberstrass S, Rosenbauer J, Baechle C, Roden M, Holl RW, Mayatepek E, Kummer S, Meissner T, Jacobsen M. JOURNAL OF AUTOIMMUNITY. PubMed
  • IL-7RA haplotypes differentially affect soluble IL-7 receptor and IL-7 serum concentrations in children with type 1 diabetes. Seyfarth J, Lundtoft C, Foertsch K, Ahlert H, Rosenbauer J, Baechle C, Roden M, Holl RW, Mayatepek E, Kummer S, Meissner T, Jacobsen M.PEDIATRIC DIABETES. PubMed
  • CISH promoter polymorphism effects on T cell cytokine receptor signaling and type 1 diabetes susceptibility. Seyfarth J, Ahlert H, Rosenbauer J, Baechle C, Roden M, Holl RW, Mayatepek E, Meissner T, Jacobsen M. MOLECULAR & CELLULAR PEDIATRICS. PubMed
  • Immune profiling in Mansonella perstans microfilaremic individuals reveals enhanced type 2 helper T and regulatory T and B cell subsets accompanied with dampened systemic innate and adaptive immune responses. Ritter M, Chounna Ndongmo WP, Njouendou AJ, Nganyewo Nghochuzie N, Nchang LC, Tayong DB, Arndts K, Nausch N, Jacobsen M,Wanji S, Layland LE, Hoerauf A. PLoS NEGLECTED TROPICAL DISEASES. PubMed

2017
  • Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis. Lundtoft C, Afum-Adjei Awuah A, Rimpler J, Harling K, Nausch N, Kohns M, Adankwah E, Lang F, Olbrich L, Mayatepek E, Owusu-Dabo E, Jacobsen M. PLOS PATHOGENSPubMed
  • Dominant TNFa and impaired IL-2 cytokine profiles of CD4+ T cells from Children with type-1-diabetes. Seyfarth J, Foertsch K, Ahlert H, Laws H-J, Karges B, Deenen R, Koehrer K, Mayatepek E, Meissner T, Jacobsen M. IMMUNOLOGY AND CELL BIOLOGY. PubMed
  • Alternative Quantiferon cytokines for diagnosis of children with active tuberculosis and HIV co-infection in Ghana. LundtoftC, Awuah AA, Nausch N, Enimil A, Mayatepek E, Owusu-Dabo E, JacobsenM. MEDICAL MICROBIOLOGY AND IMMUNOLOGYPubMed
  • A novel mycobacterial in vitro infection assay identifies differences of induced macrophage apoptosis between CD4+ and CD8+ T cells. Nkwouano V, Witkowski S, Rehberg N, Kalscheuer R, NauschN, Mayatepek E, JacobsenM. PLOS ONE. PubMed
  • Multiple cytokines for detection of Mycobacterium tuberculosis infection in children with tuberculosis. Nausch N, Lundtoft C, Schulz G, Henckel H, Mayatepek E, Fleischer B, Marx FM, Jacobsen M. THE INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE. PubMed
  • Analysis of Mycobacterium ulcerans-specific T-cell cytokines for diagnosis of Buruli ulcer disease and as potential indicator for disease progression. Nausch N, Antwi-Berko D, Mubarik Y, Abass KM, Owusu W, Owusu-Dabo E, Debrah LB, Debrah AY, JacobsenM, Phillips RO. PLoS NEGLECTED TROPICAL DISEASESPubMed
  • Re: "It May Be Too Early to Try to Prove the Effect of Deworming on Tuberculin Reactivity". Van der Zalm MM, van Soelen N, Mandalakas AM, JacobsenM, Detjen AK, Marx FM, Grewal HM, Cotton MF, Walzl G, HesselingAC. PEDIATRIC INFECTIOUS DISEASES JOURNAL. PubMed
  • Epidemiology of Mansonella perstans in the middle belt of Ghana. Debrah LB, Nausch N, Opoku VS, Owusu W, Mubarik Y, Berko DA, Wanji S, Layland LE, Hoerauf A, Jacobsen M, Debrah AY, Phillips RO. PARASITES & VECTORSPubMed

  • Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis. Lundtoft C, Afum-Adjei Awuah A, Rimpler J, Harling K, Nausch N, Kohns M, Adankwah E, Lang F, Olbrich L, Mayatepek E, Owusu-Dabo E, Jacobsen M. PLOS PATHOGENS. PubMed
  • Dominant TNFa and impaired IL-2 cytokine profiles of CD4+ T cells from Children with type-1-diabetes. Seyfarth J, Foertsch K, Ahlert H, Laws H-J, Karges B, Deenen R, Koehrer K, Mayatepek E, Meissner T, Jacobsen M. IMMUNOLOGY AND CELL BIOLOGY. PubMed
  • Alternative Quantiferon cytokines for diagnosis of children with active tuberculosis and HIV co-infection in Ghana. LundtoftC, Awuah AA, Nausch N, Enimil A, Mayatepek E, Owusu-Dabo E, JacobsenM. MEDICAL MICROBIOLOGY AND IMMUNOLOGY. PubMed
  • A novel mycobacterial in vitro infection assay identifies differences of induced macrophage apoptosis between CD4+ and CD8+ T cells. Nkwouano V, Witkowski S, Rehberg N, Kalscheuer R, NauschN, Mayatepek E, JacobsenM. PLOS ONE. PubMed
  • Multiple cytokines for detection of Mycobacterium tuberculosis infection in children with tuberculosis. Nausch N, Lundtoft C, Schulz G, Henckel H, Mayatepek E, Fleischer B, Marx FM, Jacobsen M. THE INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE. PubMed
  • Analysis of Mycobacterium ulcerans-specific T-cell cytokines for diagnosis of Buruli ulcer disease and as potential indicator for disease progression. Nausch N, Antwi-Berko D, Mubarik Y, Abass KM, Owusu W, Owusu-Dabo E, Debrah LB, Debrah AY, JacobsenM, Phillips RO. PLoS NEGLECTED TROPICAL DISEASES. PubMed
  • Re: "It May Be Too Early to Try to Prove the Effect of Deworming on Tuberculin Reactivity". Van der Zalm MM, van Soelen N, Mandalakas AM, JacobsenM, Detjen AK, Marx FM, Grewal HM, Cotton MF, Walzl G, HesselingAC. PEDIATRIC INFECTIOUS DISEASES JOURNAL. PubMed
  • Epidemiology of Mansonella perstans in the middle belt of Ghana. Debrah LB, Nausch N, Opoku VS, Owusu W, Mubarik Y, Berko DA, Wanji S, Layland LE, Hoerauf A, Jacobsen M, Debrah AY, Phillips RO. PARASITES & VECTORS. PubMed

2016
  • The Effect of Deworming on Tests of Tuberculosis Infection in Children with Recent Tuberculosis Exposure: A Randomized Controlled Trial. Van der Zalm MM, van Soelen N, Mandalakas A M, Jacobsen M, Detjen AK, Marx FM, Grewal, HM, Cotton MF, Walzl G, Hesseling, AC. PEDIATRIC INFECTIOUS DISEASES JOURNAL. PubMed

  • The Effect of Deworming on Tests of Tuberculosis Infection in Children with Recent Tuberculosis Exposure: A Randomized Controlled Trial. Van der Zalm MM, van Soelen N, Mandalakas A M, Jacobsen M, Detjen AK, Marx FM, Grewal, HM, Cotton MF, Walzl G, Hesseling, AC. PEDIATRIC INFECTIOUS DISEASES JOURNAL. PubMed

2015
  • Rapid detection and immune characterization of Mycobacterium abscessus infection in cystic fibrosis patients. Steindor M, Nkwouano V, Mayatepek E, Mackenzie CR, Schramm D, Jacobsen M. PLOS ONE. PubMed

  • Rapid detection and immune characterization of Mycobacterium abscessus infection in cystic fibrosis patients. Steindor M, Nkwouano V, Mayatepek E, Mackenzie CR, Schramm D, Jacobsen M. PLOS ONE. PubMed

2014
  • Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis. Afum-Adjei Awuah A, Ueberberg B, Owusu-Dabo E, Frempong M, Jacobsen M. INTERNATIONAL IMMUNOLOGY. PubMed
  • Co-infection with Mycobacterium ulcerans and Mansonella perstans among Buruli ulcer patients in Ghana. Phillips RO, Frimpong M, Sarfo SF, Kretschmer B, Beissner M, Debrah A, Amoako YA, Abass KM, Thompson W, Sarpong Duah M, Abotsi J, Adjei O, Fleischer B, Bretzel G, Wansbrough-Jones M, Jacobsen M. EMERGING INFECTIOUS DISEASES JOURNAL. PubMed
  • Differential gene expression of activating Fcγ receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity.CLINICAL MICROBIOLOGY AND INFECTION. Sutherland JS, Loxton AG, Haks MC, Kassa D, Ambrose L, Lee JS, Ran L, van Baarle D, Maertzdorf J, Howe R, Mayanja-Kizza H, Boom WH, Thiel BA, Crampin AC, Hanekom W, Ota MO, Dockrell H, WalzlG, Kaufmann SH, Ottenhoff TH; GCGH Biomarkers for TB consortium. u.a. Jacobsen M PubMed
  • Are microRNAs suitable biomarkers of immunity to tuberculosis? Ueberberg B, Kohns M, Mayatepek E, Jacobsen M. MOLECULAR AND CELLULAR PEDIATRICS. PubMed

  • Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis. Afum-Adjei Awuah A, Ueberberg B, Owusu-Dabo E, Frempong M, Jacobsen M. INTERNATIONAL IMMUNOLOGY. PubMed
  • Co-infection with Mycobacterium ulcerans and Mansonella perstans among Buruli ulcer patients in Ghana. Phillips RO, Frimpong M, Sarfo SF, Kretschmer B, Beissner M, Debrah A, Amoako YA, Abass KM, Thompson W, Sarpong Duah M, Abotsi J, Adjei O, Fleischer B, Bretzel G, Wansbrough-Jones M, Jacobsen M. EMERGING INFECTIOUS DISEASES JOURNAL. PubMed
  • Differential gene expression of activating Fcγ receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity.CLINICAL MICROBIOLOGY AND INFECTION. Sutherland JS, Loxton AG, Haks MC, Kassa D, Ambrose L, Lee JS, Ran L, van Baarle D, Maertzdorf J, Howe R, Mayanja-Kizza H, Boom WH, Thiel BA, Crampin AC, Hanekom W, Ota MO, Dockrell H, WalzlG, Kaufmann SH, Ottenhoff TH; GCGH Biomarkers for TB consortium. u.a. Jacobsen M PubMed
  • Are microRNAs suitable biomarkers of immunity to tuberculosis? Ueberberg B, Kohns M, Mayatepek E, Jacobsen M. MOLECULAR AND CELLULAR PEDIATRICS. PubMed

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