Liste der Veröffentlichungen / Publications:

  • IL7RA genetic variants differentially affect IL-7Rα expression and alternative splicing: a role in autoimmune and infectious diseases? Lundtoft C, Seyfarth J, Jacobsen M. GENES AND IMMUNITY. PubMed

  • Identification and validation of host biomarkers for leprosy: A step forward to establish point-of-care tests. Nausch N, Jacobsen M. EBIOMEDICINE. Pubmed
  • Suppressor of  Cytokine Signaling 3 is crucial for Interleukin-7 receptor re-expression after T-cell activation and Interleukin-7 dependent proliferation. Güler A, Lopez Venegas M, Adankwah E, Mayatepek E, Nausch N, Jacobsen M. EUROPEAN JOURNAL OF IMMUNOLOGY. PubMed
  • Type-1 diabetes onset age and sex differences between Ghanaian and German urban populations. Seyfarth J, Sarfo-Kantanka O, Rosenbauer J, Phillips RO, Jacobsen M. JOURNAL OF DIABETES. PubMed
  • CD27 expression of T-cells discriminates IGRA-negative TB patients from healthy contacts in Ghana. Adankwah E, Güler A, Mayatepek E, Phillips RO, Nausch N, Jacobsen M. MICROBES AND INFECTION. PubMed
  • Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana. Adankwah E, Lundtoft C, Güler A, Franken KLMC, Ottenhoff THM, Mayatepek E, Owusu-Dabo E, Phillips RO, Nausch N, Jacobsen M. FRONTIERS IN IMMUNOLOGY. PubMed
  • The Efficacy of Doxycycline Treatment on Mansonella perstans Infection: An Open-Label, Randomized Trial in Ghana. Batsa Debrah L, Phillips RO, Pfarr K, Klarmann-Schulz U, Opoku VS, Nausch N, Owusu W, Mubarik Y, Sander AL, Lämmer C, Ritter M, Layland LE, Jacobsen M, Debrah AY, Hoerauf A. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. PubMed
  • CD4T-Cells with high common γ chain expression and disturbed cytokine production are enriched in children with Type-1 Diabetes. Seyfarth J, Mütze N, Antony Cruz J, Kummer S, Reinauer C, Mayatepek E, Meissner T, Jacobsen M. FRONTIERS IN IMMUNOLOGY. PubMed
  • Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression characterize impaired T-cell functions in tuberculosis patients. HarlingK, AdankwahE, Güler A, Afum-Adjei Awuah A, Adu-Amoah L, Mayatepek E, Owusu-Dabo E, Nausch N, Jacobsen M. CELLULAR & MOLECULAR IMMUNOLOGY. PubMed
  • Higher Interleukin-7 serum concentrations in patients with cystic fibrosis correlate with impaired lung function. Seyfarth J, Sivagurunathan S, Ricken S, Weinreich G, Olbrich L, Taube C, Mayatepek E, Schramm D, Jacobsen M. JOURNAL OF CYSTIC FIBROSIS. PubMed

  • A Systematic Review on Novel Mycobacterium tuberculosis Antigens and Their Discriminatory Potential for the Diagnosis of Latent and Active Tuberculosis. Meier NR, Jacobsen M, Ottenhoff THM, Ritz N. FRONTIERS IN IMMUNOLOGY. PubMed
  • A proteomics approach for the identification of species-specific immunogenic proteins in the Mycobacterium abscessus complex. Steindor M, Nkwouano V, Stefanski A, Stuehler K, Ioerger TR, Bogumil D, Jacobsen M, Mackenzie CR, Kalscheuer R. MICROBES AND INFECTION. PubMed
  • An IL7RA exon 5 polymorphism is associated with impaired IL-7Rα splicing and protection against tuberculosis in Ghana. Lundtoft C, Awuah AA, Güler A, Harling K, Schaal H, Mayatepek E, Phillips RO, Nausch N, Owusu-Dabo E, Jacobsen M. GENES AND IMMUNITY. PubMed
  • Autoimmunity risk- and protection-associated IL7RA genetic variants differentially affect soluble and membrane IL-7Rα expression. Lundtoft C, Seyfarth J, Oberstrass S, Rosenbauer J, Baechle C, Roden M, Holl RW, Mayatepek E, Kummer S, Meissner T, Jacobsen M. JOURNAL OF AUTOIMMUNITY. PubMed
  • IL-7RA haplotypes differentially affect soluble IL-7 receptor and IL-7 serum concentrations in children with type 1 diabetes. Seyfarth J, Lundtoft C, Foertsch K, Ahlert H, Rosenbauer J, Baechle C, Roden M, Holl RW, Mayatepek E, Kummer S, Meissner T, Jacobsen M.PEDIATRIC DIABETES. PubMed
  • CISH promoter polymorphism effects on T cell cytokine receptor signaling and type 1 diabetes susceptibility. Seyfarth J, Ahlert H, Rosenbauer J, Baechle C, Roden M, Holl RW, Mayatepek E, Meissner T, Jacobsen M. MOLECULAR & CELLULAR PEDIATRICS. PubMed
  • Immune profiling in Mansonella perstans microfilaremic individuals reveals enhanced type 2 helper T and regulatory T and B cell subsets accompanied with dampened systemic innate and adaptive immune responses. Ritter M, Chounna Ndongmo WP, Njouendou AJ, Nganyewo Nghochuzie N, Nchang LC, Tayong DB, Arndts K, Nausch N, Jacobsen M,Wanji S, Layland LE, Hoerauf A. PLoS NEGLECTED TROPICAL DISEASES. PubMed

  • Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis. Lundtoft C, Afum-Adjei Awuah A, Rimpler J, Harling K, Nausch N, Kohns M, Adankwah E, Lang F, Olbrich L, Mayatepek E, Owusu-Dabo E, Jacobsen M. PLOS PATHOGENSPubMed
  • Dominant TNFa and impaired IL-2 cytokine profiles of CD4+ T cells from Children with type-1-diabetes. Seyfarth J, Foertsch K, Ahlert H, Laws H-J, Karges B, Deenen R, Koehrer K, Mayatepek E, Meissner T, Jacobsen M. IMMUNOLOGY AND CELL BIOLOGY. PubMed
  • Alternative Quantiferon cytokines for diagnosis of children with active tuberculosis and HIV co-infection in Ghana. LundtoftC, Awuah AA, Nausch N, Enimil A, Mayatepek E, Owusu-Dabo E, JacobsenM. MEDICAL MICROBIOLOGY AND IMMUNOLOGYPubMed
  • A novel mycobacterial in vitro infection assay identifies differences of induced macrophage apoptosis between CD4+ and CD8+ T cells. Nkwouano V, Witkowski S, Rehberg N, Kalscheuer R, NauschN, Mayatepek E, JacobsenM. PLOS ONE. PubMed
  • Multiple cytokines for detection of Mycobacterium tuberculosis infection in children with tuberculosis. Nausch N, Lundtoft C, Schulz G, Henckel H, Mayatepek E, Fleischer B, Marx FM, Jacobsen M. THE INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE. PubMed
  • Analysis of Mycobacterium ulcerans-specific T-cell cytokines for diagnosis of Buruli ulcer disease and as potential indicator for disease progression. Nausch N, Antwi-Berko D, Mubarik Y, Abass KM, Owusu W, Owusu-Dabo E, Debrah LB, Debrah AY, JacobsenM, Phillips RO. PLoS NEGLECTED TROPICAL DISEASESPubMed
  • Re: "It May Be Too Early to Try to Prove the Effect of Deworming on Tuberculin Reactivity". Van der Zalm MM, van Soelen N, Mandalakas AM, JacobsenM, Detjen AK, Marx FM, Grewal HM, Cotton MF, Walzl G, HesselingAC. PEDIATRIC INFECTIOUS DISEASES JOURNAL. PubMed
  • Epidemiology of Mansonella perstans in the middle belt of Ghana. Debrah LB, Nausch N, Opoku VS, Owusu W, Mubarik Y, Berko DA, Wanji S, Layland LE, Hoerauf A, Jacobsen M, Debrah AY, Phillips RO. PARASITES & VECTORSPubMed

  • The Effect of Deworming on Tests of Tuberculosis Infection in Children with Recent Tuberculosis Exposure: A Randomized Controlled Trial. Van der Zalm MM, van Soelen N, Mandalakas A M, Jacobsen M, Detjen AK, Marx FM, Grewal, HM, Cotton MF, Walzl G, Hesseling, AC. PEDIATRIC INFECTIOUS DISEASES JOURNAL. PubMed




  • Rapid detection and immune characterization of Mycobacterium abscessus infection in cystic fibrosis patients. Steindor M, Nkwouano V, Mayatepek E, Mackenzie CR, Schramm D, Jacobsen M. PLOS ONE. PubMed



  • Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis. Afum-Adjei Awuah A, Ueberberg B, Owusu-Dabo E, Frempong M, Jacobsen M. INTERNATIONAL IMMUNOLOGY. PubMed
  • Co-infection with Mycobacterium ulcerans and Mansonella perstans among Buruli ulcer patients in Ghana. Phillips RO, Frimpong M, Sarfo SF, Kretschmer B, Beissner M, Debrah A, Amoako YA, Abass KM, Thompson W, Sarpong Duah M, Abotsi J, Adjei O, Fleischer B, Bretzel G, Wansbrough-Jones M, Jacobsen M. EMERGING INFECTIOUS DISEASES JOURNAL. PubMed
  • Differential gene expression of activating Fcγ receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity.CLINICAL MICROBIOLOGY AND INFECTION. Sutherland JS, Loxton AG, Haks MC, Kassa D, Ambrose L, Lee JS, Ran L, van Baarle D, Maertzdorf J, Howe R, Mayanja-Kizza H, Boom WH, Thiel BA, Crampin AC, Hanekom W, Ota MO, Dockrell H, WalzlG, Kaufmann SH, Ottenhoff TH; GCGH Biomarkers for TB consortium. u.a. Jacobsen M PubMed
  • Are microRNAs suitable biomarkers of immunity to tuberculosis? Ueberberg B, Kohns M, Mayatepek E, Jacobsen M. MOLECULAR AND CELLULAR PEDIATRICS. PubMed

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