Selected publications

• Inak G, Rybak-Wolf A, Lisowski P, Pentimalli TM, Jüttner R, Glažar P, Uppal K, Bottani E, Brunetti D, Secker C, Zink A, Meierhofer D, Henke MT, Dey M, Ciptasari U, Mlody B, Hahn T, Berruezo-Llacuna M, Karaiskos N, Di Virgilio M, Mayr JA, Wortmann SB, Priller J, Gotthardt M, Jones DP, Mayatepek E, Stenzel W, Diecke S, Kühn R, Wanker EE, Rajewsky N, Schuelke M, Prigione A. Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome. Nat Commun. 2021, Mar 26;12(1):1929. DOI: 10.1038/s41467-021-22117-z. PMID: 33771987.
• Zink, A., Lisowski, P. and Prigione, A. Generation of Human iPSC-derived Neural Progenitor Cells (NPCs) as Drug Discovery Model for Neurological and Mitochondrial Disorders. Bio-protocol 11(5): e3939. 2021; DOI: 10.21769/BioProtoc.3939
• Zink A, Conrad J, Telugu NS, Diecke S, Heinz A, Wanker EE, Priller J, and Prigione A. Assessment of ethanol-induced toxicity on iPSC-derived human neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay. Front. Cell Dev. Biol. 2020 Oct 15; DOI: 10.3389/fcell.2020.590540
• Cunnane SC1, Trushina E, Morland C, Prigione A, Casadesus G, Andrews ZB, Beal MF, Bergersen LH, Brinton RD, de la Monte S, Eckert A, Harvey JZ, Jeggo R, Jhamandas JH, Kann O, Mannoury la Cour C, Martin WF, Mithieux G, Moreira PI, Murphy MP, Nave KA, Nuriel T, Oliet SHR, Saudou F, Mattson MP, Swerdlow RH, Millan MJ. Brain energy rescue: an emerging concept for new therapeutics in neurodegenerative disorders of aging. Nat Rev Drug Disc, 2020.
• Delgado-Benito V, Berruezo-Llacuna M, Altwasser R, Winkler W, Sundaravinayagam D, Balasubramanian S, Caganova M, Graf R, Rahjouei A, Henke M, Driesner M, Keller L, Prigione A, Janz M, Akalin A, Di Virgilio M. Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification. J Exp Med, 2020.
• Laidou S, Alanis-Lobato G, Pribyl J, Rasko T, Tichy B, Mikulasek K, Tsagiopoulou M, Oppelt J, Kastrinaki G, Lefaki M, Singh M, Zink A, Chondrogianni N, Psomop F, Prigione A, Ivics Z, Popsilova S, Skadal P, Izsvak Z, Petrakis S. Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery. Redox Biology, 11.02.2020, 101458.
• Menacho C, Prigione A. Tackling mitochondrial diversity in brain function: from animal models to human brain organoids. Int J Biochem Cell Biol. 2020.
• Iannetti EF, Prigione A, Smeitink JAM, Koopman WJH, Beyrath J, Renkema H. Live-Imaging Readouts and Cell Models for Phenotypic Profiling of Mitochondrial Function. Front Genet. 2019 Mar 1;10:131.
• Ploski R, Rydzanicz M, Wachowska M, Cook E, Lisowski P, Kuzniewska B, Szymańska K, Diecke S, Prigione A, Szczałuba K, Szybińska A, Koppolu A, Pienkowski VM, Kosińska J, Wiweger M, Kostrzewa G, Brzozowska M, Domańska-Pakieła D, Jurkiewicz E, Stawinski P, Gromadka A, Zielenkiewicz P, Demkow U, Dziembowska M, Kuźnicki J, Novel TC. Calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression. Eur J Hum Genet. 2018.
• Lisowski P, Kannan P, Mlody B, Prigione A. Mitochondria and the dynamic control of stem cell homeostasis. EMBO Rep. 2018, May;19(5).
• Zink A, Priller J, Prigione A. Pluripotent stem cells for uncovering the role of mitochondria in human brain function and dysfunction. J Mol Biol. 2018 Feb 16.
• Lorenz C, Prigione A. Mitochondrial metabolism in early neural fate and its relevance in neuronal disease modeling. Curr Opin Cell Biol. 2017 Dec;49:71-76.
• Scior A, Arnsburg K, Iburg M, Juenemann K, Pigazzini ML, Mlody B, Puchkov D, Ast A, Buntru A, Priller J, Wanker EE, Prigione A, Kirstein J. Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex. EMBO J. 2018 Jan 17;37(2):282-299.
• Jadasz JJ, Tepe L, Beyer F, Samper Agrelo I, Akkermann R, Spitzhorn LS, Silva ME, Oreffo ROC, Hartung HP, Prigione A, Rivera FJ, Adjaye J, Küry P. Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis. Glia. 2018 Jan;66(1):145-160.
• Inak G, Lorenz C, Lisowski P, Zink A, Mlody B, Prigione A. iPSC-based drug discovery for mitochondrial disease. Stem Cells. 2017 Jul;35(7):1655-1662.
• Lorenz C, Lesimple P, Bukowiecki R, Zink A, Inak G, Mlody B, Singh M, Semtner M, Mah N, Leong M, Auré K, Pfiffer V, Fauler B, Eichhorst J, Lyras EM, Wiesner B, Priller J, Huebner N, Mielke T, Meierhofer D, Izsvák Z, Meier JC, Bouillaud F, Adjaye J, Wanker E, Schuelke M, Lombès A, Prigione A. Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders. Cell Stem Cell. 2017, May 4;20(5):659-674.
• Schottmann G, Sarpong A, Lorenz C, Weinhold N, Gill E, Teschner L, Wanders RJA, Prigione A, Schuelke M. A movement disorder with dystonia and ataxia caused by a mutation in the HIBCH gene. Mov Dis. 2016, Nov;31(11):1733-39.
• Izsvák Z, Wang J, Singh M, Besser D, Prigione A, Ivics Z, Hurst L, Sun C. Isolation and Cultivation of Naïve-like Human Pluripotent Stem Cells based on LTR7/HERVH Expression. Nature Protocols. 2016, 11(2):327-346.
• Prigione A. Editorial - A mitochondrial view of cell fate. Semin Cell Dev Biol. 2016 Apr;52:66-7.
• Wang J, Xie G, Singh M, Ghanbarian AT, Raskó T, Szvetnik A, Cai H, Besser D, Prigione A, Fuchs N, Schumann G, Chen W, Lorincz MC, Ivics Z, Hurst LD, Izsvák Z. Primate-specific endogenous retrovirus driven transcription defines naïve-like stem cells. Nature. 2014, Dec 18;516(7531):405-9. [IF: 42.3]
• Mlody B, Prigione A. A Glycolytic Solution for Pluripotent Stem Cells. Cell Stem Cell. 2016, Oct 6;19(4):419-420.
• Prigione A, Rohwer N, Hoffmann S, Mlody B, Drews K, Bukowiecki R, Bluemlein K, Wanker EE, Ralser M, Cramer T, Adjaye J. HIF1α modulates cell fate reprogramming through early glycolytic shift and up-regulation of PDK1-3 and PKM2. Stem Cells. 2014 Feb;32(2):364-76.
• Stincone A, Prigione A, Cramer T, Wamelink MMC, Campbell K, Cheung E, Viridiana Olin-Sandoval M, Gruening NM, Krueger A, Tauqeer Alam M, Keller MA, Breitenbach M, Brindle K, Rabinowitz J, Ralser M. The return of metabolism: Biochemistry and Physiology of the Pentose Phosphate Pathway. Biol Rev. 2015 Aug;90(3):927-63
• Prigione A, Lichtner B, Kuhl H, Struys EA, Wamelink M, Lehrach H, Ralser M, Timmermann B, Adjaye J. Human iPSCs Harbor Homoplasmic and Heteroplasmic Mitochondrial DNA Mutations While Maintaining hESC-Like Metabolic Reprogramming. Stem Cells. 2011 Sep;29(9):1338-48.
• Prigione A, Fauler B, Lurz R, Lehrach H, Adjaye J. The Senescence-Related Mitochondrial /Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells. Stem Cells. 2010 Apr;28(4):721-33.
• Prigione A, Cortopassi G. Mitochondrial DNA deletions induce the adenosine monophosphate-activated protein kinase energy stress pathway and result in decreased secretion of some proteins. Aging Cell. 2007 Oct;6(5):619-30.

Pre-print publications

• Inak G, Rybak-Wolf A, Lisowski P, Jüttner R, Zink A, Mlody B, Glažar P, Secker C, Ciptasari UH, Stenzel W, Hahn T, Diecke S, Priller J, Gotthardt M, Kühn R, Wanker EE, Rajewsky N, Schülke M, Prigione A. SURF1 mutations causative of Leigh syndrome impair human neurogenesis. BioRxiv. 2019, doi.org/10.1101/551390.