Details zum Stellenangebot
Stellenbezeichnung PhD Student , 154E/19
Arbeitsbeginn ab sofort
Berufsgrupppe Wissenschaftlicher Dienst
Einrichtung institut of Biochemistry and Molecular Biology


PhD student position Redox-active Nanoparticles in tumor Progression in Düsseldorf

 

We are looking for a highly motivated PhD student for a project on the role of redox-active nanoparticles in cancer therapy in the lab of Prof. Peter Brenneisen, Institute of Biochemistry and Molecular Biology 1, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. We are an institute with very well equipped labs and a collaborative working environment.

Tumor progression and metastasis are a therapeutical challenge in the context of development of drug resistance. Furthermore, a large number of effective anticancer agents already exist, but in most cases the application is accompanied by severe side effects mediated by normal (healthy) cells. However, the application of specific (redox-active) nanoparticles either alone or in combination with classical chemotherapeutics seems a novel promising tool in fighting against cancer. In the center of this DFG funded project, the molecular effects of redox-active nanoparticles used alone or in a combinational approach will be studied focusing on mitochondrial dynamics/quality control as well as on mitophagy and autophagy. Here, we will use state-of-the-art techniques including live-cell confocal fluorescence microscopy, electron microscopy, and standard molecular biological and cell biological/biochemical tools to assess the role of these nanoparticles in prevention of tumor invasion.

We are looking for a strong candidate having

 

·      A master degree (or equivalent) in biochemistry, biology, chemistry, or other closely related fields of natural sciences.

·      practical experience in laboratory  work and basic biochemistry, molecular  biology and cell biology techniques .

·      very good proficiency in writing and speaking English.

·      strong interest to work at an international institute

·      passion for science and the motivation to work on an innovative project.

 

 

Job Position

 

A PhD student position (E13, 65%) for the period of 2 year with the possibility of extension for an additional year.

The Heinrich-Heine-University Düsseldorf is committed to equal opportunity in employment and gender equality in its working environment. Handicapped applicants with equal qualifications will be preferred.

Application procedure

 

Please send your full application (in English or German) in a single pdf-file which includes your CV, relevant transcripts, and a motivation letter to 1 page) explaining why studying the effect of nanoparticles in tumor progression is of interest to you and why you are suited for this scientific project. Only complete applications sent as a single pdf-file to Prof. Peter Brenneisen (peter.brenneisen@hhu.de) will be considered.

 

 

Universitätsklinikum Düsseldorf

D 01.2.1 – Kennziffer: 154E/19, Moorenstr. 5, 40225 Düsseldorf



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