The Cognitive Symptoms of Parkinson's Disease

from Neurophysiology to Therapeutic Neuromodulation

Parkinson's disease is a progressive neurodegenerative disorder primarily characterized by motor symptoms. In addition, patients suffer from a variety of non-motor symptoms. Among these symptoms, cognitive impairments are of particular clinical relevance.

Currently, only few options are available for the treatment of cognitive symptoms in Parkinson's disease. However, there is evidence that, with the right settings, deep brain stimulation (DBS) could improve certain cognitive abilities. With this research program, we aim to comprehensively investigate this possibility.

Furthermore, we are examining neural correlates of cognition and their development over the years using electrophysiological measurements and neuroimaging. The project runs from 2026 to 2028, with the prospect of a two-year extension. It is funded by the Brunhilde Moll Foundation.

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