Main research topics

• Myocardial metabolism and mitochondria
• Pathomechanism of cardiovascular calcification

Current projects

• Myocardial metabolism in heart failure
• Oxidative capacity in myocardial ischemia
• Matrix-Gla protein and cardiovascular calcification
• beta1 activating antibodies in heart failure

Collaborations

• Prof. Dr. L. Schurgers (CARIM, Maastricht, NL)
• Prof. Dr. W. Jahnen-Dechent (Helmholtz Institut, Aachen)

Selected publications

• ScheiberD, Zweck E, Jelenik T, Horn P, Albermann S, Masyuk M, Boeken U, Saeed D, Kelm M, Roden M, Szendroedi J, Westenfeld R. Reduced Myocardial Mitochondrial ROS Production in Mechanically Unloaded Hearts. J CardiovascTranslRes2018 [Epub ahead of print]
• Hilfiker-KleinerD, Haghikia A, Berliner D, Vogel-Claussen J, Schwab J, Franke A, Schwarzkopf M, Ehlermann P, Pfister R, Michels G, Westenfeld R, Stangl V, Kindermann I, Kühl U, Angermann CE, Schlitt A, Fischer D, Podewski E, Böhm M, Sliwa K, Bauersachs J. Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study. EurHeart J. 2017;38(35):2671-2679
• BoegeF, Westenfeld R, Jahns R. β1AAb Determinedby Peptide ELISA: A Signal in the Noise? J Am CollCardiol. 2017;70(6):807-808
• BönnerF, Spieker M, Haberkorn S, Jacoby C, Flögel U, Schnackenburg B, Horn P, Reinecke P, Neizel-Wittke M, Kelm M, Westenfeld R. Myocardial T2 Mapping IncreasesNoninvasiveDiagnosticAccuracyforBiopsy-ProvenMyocarditis. JACC Cardiovasc Imaging.2016;9(12):1467-1469.
• Scheiber D, Veulemans V, Horn P, Chatrou ML, Potthoff SA, Kelm M, Schurgers LJ, Westenfeld R. High-Dose Menaquinone-7 Supplementation ReducesCardiovascularCalcification in a Murine Model ofExtraosseousCalcification. Nutrients. 2015;7(8):6991-7011
• Horn P, Stern D, Veulemans V, Heiss C, Zeus T, Merx MW, Kelm M, Westenfeld R. Improvedendothelialfunctionanddecreasedlevelsofendothelium-derivedmicroparticles after transcatheteraorticvalveimplantation. EuroIntervention. 2015;(12):1456-63.
• Krüger T, Oelenberg S, Kaesler N, Schurgers LJ, van de Sandt AM, Boor P, Schlieper G, Brandenburg VM, Fekete BC, Veulemans V, Ketteler M, Vermeer C, Jahnen-Dechent W, Floege J, Westenfeld R. Warfarininducescardiovasculardamage in mice. ArteriosclerThrombVascBiol. 2013;(11):2618-24.
• WestenfeldR, Schäfer C, Krüger T, Haarmann C, Schurgers LJ, Reutelingsperger C, Ivanovski O, Drueke T, Massy ZA, Ketteler M, Floege J, Jahnen-Dechent W. Fetuin-A protects against atherosclerotic calcification in CKD. J Am SocNephrol. 2009;20(6):1264-74.
• SchäferC, Heiss A, Schwarz A, Westenfeld R, Ketteler M, Floege J, Müller-EsterlW, Schinke T, Jahnen-Dechent W. The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J ClinInvest. 2003;112(3):357-66
• KettelerM, Bongartz P, Westenfeld R, Wildberger JE, Mahnken AH, Böhm R, Metzger T, Wanner C, Jahnen-Dechent W, Floege J. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet. 2003;361(9360):827-33