Pulmonary hypertension
Clinical research in pulmonary hypertension focuses on

  • the understanding and management of pulmonary hypertension in left heart disease, e.g. pulmonary hypertension in aortic stenosis and right heart failure in systolic left ventricular dysfunction
  • modern imaging modalities for accurate assessment of right heart structure and function

Heart lung interactions
Clinical research in heart lung interactions focuses on

  • Cardiovascular disease in chronic obstructive lung disease
  • Chronic obstructive pulmonary disease (COPD) leads to a structural and functional impairment of the lungs resulting in the typical symptoms cough and dyspnoea. Despite the local effects, COPD is understood as a systemic disease which includes cardiovascular disease such as myocardial ischemia, left ventricular dysfunction, pulmonary hypertension or arrhythmias. The aforementioned cardiovascular manifestations in COPD may explain the relevant cardiovascular morbidity and mortality in stable, and even more in exacerbated COPD.
  • Sleep apnoea and cardiovascular disease (atrial fibrillation, aortic valve stenosis)
    Epidemiological and clinical studies found increased proportions of central or obstructive sleep apnea in patients with cardiovascular diseases e.g. atrial fibrillation or aortic valve stenosis. It is of high clinical and scientific interest to understand the underlying pathophysiology and clinical consequences to develop ideal treatment strategies both entities - for lung disease and for the heart disease.

Core methods:

  • Right heart echocardiography
  • Vascular function for the evaluation of macrovascular and microvascular function (via the core lab)    
    • Flow mediated dilation
    • Venous occlusion plethysmography
    • Laser Doppler Flowmetry
  • Red blood cell function (via the core lab)
    • Red blood cell deformability
    • Red blood cell aggregation
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