Ausgewählte Publikationen zu Bauchtumoren


Prognostic significance of EpCAM-positive disseminated tumor cells in rectal cancer patients with stage I disease.
Dhayat S, Sorescu S, Vallböhmer D, Kraus S, Baldus SE, Rehders A, Kröpil F, Krieg A, Knoefel WT, Stoecklein NH.
Am J Surg Pathol. 2012 Dec;

Notch 1 tumor expression is lacking in highly proliferative pancreatic neuroendocrine tumors.
Krausch M, Kroepil F, Lehwald N, Lachenmayer A, Schott M, Anlauf M, Cupisti K, Knoefel WT, Raffel A.
Endocrine. 2012 Dec 7. [Epub ahead of print]

Down-regulation of CDH1 is associated with expression of SNAI1 in colorectal adenomas.
Kroepil F, Fluegen G, Totikov Z, Baldus SE, Vay C, Schauer M, Topp SA, Esch JS, Knoefel WT, Stoecklein NH.
PLoS One. 2012; Epub 2012 Sep 28.

Vascular invasion in pancreatic cancer: tumor biology or tumor topography?
Rehders A, Stoecklein NH, Güray A, Riediger R, Alexander A, Knoefel WT.
Surgery. 2012 Sep; Epub 2012 Jul 3

The role of lymphadenectomy in the surgical treatment of esophageal and gastric cancer.
Vallbohmer D, Oh DS, Peters JH.
Curr Probl Surg. 2012 Aug;

Duodenal gastrointestinal stroma tumours: difficulties of an individualized risk assessment and controversies in surgical therapy.
Vallböhmer D, Knoefel WT.
Int J Colorectal Dis. 2012 Aug; Epub 2012 Apr 20.

The simultaneous expression of both ephrin B3 receptor and E-cadherin in Barrett`s adenocarcinoma is associated with favorable clinical staging.
Schauer MC, Stoecklein NH, Theisen J, Kröpil F, Baldus S, Hoelscher A, Feith M, Bölke E, Matuschek C, Budach W, Knoefel WT.
Eur J Med Res. 2012 May 14;

Radiotherapy in elderly patients with inoperable esophageal cancer. Is there a benefit?
Semrau R, Herzog SL, Vallböhmer D, Kocher M, Hölscher A, Müller RP.
Strahlenther Onkol. 2012 Mar; Epub 2012 Feb 10.

Roles of thymidylate synthase and dihydropyrimidine dehydrogenase expression in blood as predictors of response to multimodal therapy in esophageal cancer.
Brabender J, Metzger R, Vallböhmer D, Ling F, Neiss S, Bollschweiler E, Schneider PM, Hölscher AH, Grimminger PP.
Surgery. 2012 Feb; Epub 2011 Oct 6.

Neoadjuvant radiochemotherapy in adenocarcinoma of the esophagus: ERCC1 gene polymorphisms for prediction of response and prognosis.
Metzger R, Warnecke-Eberz U, Alakus H, Kütting F, Brabender J, Vallböhmer D, Grimminger PP, Mönig SP, Drebber U, Hölscher AH, Bollschweiler E.
J Gastrointest Surg. 2012 Jan; Epub 2011 Sep 29.

Ausgewählte Publikationen zu Brustkrebs


Loss of heterozygosity at tumor suppressor genes detectable on fractionated circulating cell-free tumor DNA as indicator of breast cancer progression.

Schwarzenbach H, Eichelser C, Kropidlowski J, Janni W, Rack B, Pantel K.
Clin Cancer Res. 2012 Oct 15. Epub 2012 Sep 25.

Long-term outcome after neoadjuvant radiochemotherapy in locally advanced noninflammatory breast cancer and predictive factors for a pathologic complete remission : results of a multivariate analysis.
Matuschek C, Bölke E, Roth SL, Orth K, Lang I, Bojar H, Janni JW, Audretsch W, Nestle-Kraemling C, Lammering G, Speer V, Gripp S, Gerber PA, Buhren BA, Sauer R, Peiper M, Schauer M, Dommach M, Struse-Soll K, Budach W.
Strahlenther Onkol. 2012 Sep. Epub 2012 Aug 11.

Mastectomy trends for early-stage breast cancer: a report from the EUSOMA multi-institutional European database.
Garcia-Etienne CA, Tomatis M, Heil J, Friedrichs K, Kreienberg R, Denk A, Kiechle M, Lorenz-Salehi F, Kimmig R, Emons G, Danaei M, Heyl V, Heindrichs U, Rageth CJ, Janni W, Marotti L, del Turco MR, Ponti A; eusomaDB Working Group.
Eur J Cancer. 2012 Sep. Epub 2012 Apr 4

Influence of zoledronic acid on disseminated tumor cells in primary breast cancer patients.
Solomayer EF, Gebauer G, Hirnle P, Janni W, Lück HJ, Becker S, Huober J, Krämer B, Wackwitz B, Wallwiener D, Fehm T.
Ann Oncol. 2012 Sep. Epub 2012 Mar 1.

Prognostic impact of circulating tumor cells assessed with the CellSearch System™ and AdnaTest Breast™ in metastatic breast cancer patients: the DETECT study.
Müller V, Riethdorf S, Rack B, Janni W, Fasching PA, Solomayer E, Aktas B, Kasimir-Bauer S, Pantel K, Fehm T; on behalf of the DETECT study group.
Breast Cancer Res. 2012 Aug 15 [Epub ahead of print]

Docetaxel-containing adjuvant chemotherapy in patients with early stage breast cancer. Consistency of effect independent of nodal and biomarker status: a meta-analysis of 14 randomized clinical trials.
Jacquin JP, Jones S, Magné N, Chapelle C, Ellis P, Janni W, Mavroudis D, Martín M, Laporte S.
Breast Cancer Res Treat. 2012 Aug. Epub 2012 Jan 24.

Double heterozygosity for mutations in BRCA1 and BRCA2 in German breast cancer patients: implications on test strategies and clinical management.
Heidemann S, Fischer C, Engel C, Fischer B, Harder L, Schlegelberger B, Niederacher D, Goecke TO, Doelken SC, Dikow N, Jonat W, Morlot S, Schmutzler RC, Arnold NK.
Breast Cancer Res Treat. 2012 Aug. Epub 2012 Apr 26.

Trastuzumab clears HER2/neu-positive isolated tumor cells from bone marrow in primary breast cancer patients.
Rack B, Jückstock J, Günthner-Biller M, Andergassen U, Neugebauer J, Hepp P, Schoberth A, Mayr D, Zwingers T, Schindlbeck C, Friese K, Janni W.
Arch Gynecol Obstet. 2012 Feb. Epub 2011 Jun 30.

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.
Hellebrand H, Sutter C, Honisch E, Gross E, Wappenschmidt B, Schem C, Deissler H, Ditsch N, Gress V, Kiechle M, Bartram CR, Schmutzler RK, Niederacher D, Arnold N, Meindl A.
Hum Mutat. 2011 Jun. Epub 2011 Feb 24.

Controlled extracellular matrix degradation in breast cancer tumors improves therapy by trastuzumab.
Beyer I, Li Z, Persson J, Liu Y, van Rensburg R, Yumul R, Zhang XB, Hung MC, Lieber A.
Mol Ther. 2011 Mar. Epub 2010 Nov 16.

Ausgewählte Publikationen zu Endokrinen Tumoren


Combination chemotherapy in advanced adrenocortical carcinoma.
Fassnacht M, Terzolo M, Allolio B, Baudin E, Haak H, Berruti A, Welin S, Schade-Brittinger C, Lacroix A, Jarzab B, Sorbye H, Torpy DJ, Stepan V, Schteingart DE, Arlt W, Kroiss M, Leboulleux S, Sperone P, Sundin A, Hermsen I, Hahner S, Willenberg HS, Tabarin A, Quinkler M, de la Fouchardière C, Schlumberger M, Mantero F, Weismann D, Beuschlein F, Gelderblom H, Wilmink H, Sender M, Edgerly M, Kenn W, Fojo T, Müller HH, Skogseid B; FIRM-ACT Study Group.
N Engl J Med. 2012 Jun 7. Epub 2012 May 2.

TP53 germline mutations in adult patients with adrenocortical carcinoma.
Herrmann LJ, Heinze B, Fassnacht M, Willenberg HS, Quinkler M, Reisch N, Zink M, Allolio B, Hahner S.
J Clin Endocrinol Metab. 2012 Mar

68Ga-DOTATOC versus 68Ga-DOTATATE PET/CT in functional imaging of neuroendocrine tumors.
Poeppel TD, Binse I, Petersenn S, Lahner H, Schott M, Antoch G, Brandau W, Bockisch A, Boy C. 
J Nucl Med. 2011 Dec

The immune system in neuroendocrine tumors.
Thiel A, Ehlers M, Anlauf M, Raffel A, Stoecklein NH, Schott M.
Horm Metab Res. 2011 Nov

Loss of PTEN expression in neuroendocrine pancreatic tumors.
Krausch M, Raffel A, Anlauf M, Schott M, Willenberg H, Lehwald N, Hafner D, Cupisti K, Eisenberger CF, Knoefel WT.
Horm Metab Res. 2011 Nov; Epub 2011 Nov 21.

New therapeutic options for advanced thyroid cancer.
Willhauck MJ, Schott M, Kreissl MC, Fassnacht M, Spitzweg C.
Dtsch Med Wochenschr. 2011 Jun. Epub 2011 May 24. German.

A new mutation in the menin gene causes the multiple endocrine neoplasia type 1 syndrome with adrenocortical carcinoma.
Haase M, Anlauf M, Schott M, Schinner S, Kaminsky E, Scherbaum WA, Willenberg HS.
Endocrine. 2011 Apr; Epub 2010 Nov 11. Erratum in: Endocrine. 2011 Jun.

Increased numbers of tumor-lysing monocytes in cancer patients.
Papewalis C, Jacobs B, Baran AM, Ehlers M, Stoecklein NH, Willenberg HS, Schinner S, Anlauf M, Raffel A, Cupisti K, Fenk R, Scherbaum WA, Schott M. 
Mol Cell Endocrinol. 2011 Apr 30

Chromogranin A as potential target for immunotherapy of malignant pheochromocytoma.
Papewalis C, Kouatchoua C, Ehlers M, Jacobs B, Porwol D, Schinner S, Willenberg HS, Anlauf M, Raffel A, Eisenhofer G, Neumann HP, Bornstein SR, Scherbaum WA, Schott M.
Mol Cell Endocrinol. 2011 Mar 15

Ausgewählte Publikationen zu Gynäkologischen Tumoren


A phase II trial (AGO 2.11) in platinum-resistant ovarian cancer: a randomized multicenter trial with sunitinib (SU11248) to evaluate dosage, schedule, tolerability, toxicity and effectiveness of a multitargeted receptor tyrosine kinase inhibitor monotherapy.

Baumann KH, du Bois A, Meier W, Rau J, Wimberger P, Sehouli J, Kurzeder C, Hilpert F, Hasenburg A, Canzler U, Hanker LC, Hillemanns P, Richter B, Wollschlaeger K, Dewitz T, Bauerschlag D, Wagner U.
Ann Oncol. 2012 Sep. Epub 2012 Feb 29.

Two-marker combinations for preoperative discrimination of benign and malignant ovarian masses.
Freydanck MK, Laubender RP, Rack B, Schuhmacher L, Jeschke U, Scholz C.
Anticancer Res. 2012 May

Combination of a MDR1-targeted replicative adenovirus and chemotherapy for the therapy of pretreated ovarian cancer.
Rein DT, Volkmer A, Bauerschmitz G, Beyer IM, Janni W, Fleisch MC, Welter AK, Bauerschlag D, Schöndorf T, Breidenbach M.
J Cancer Res Clin Oncol. 2012 Apr. Epub 2012 Jan 1.

Association of death receptor 4 variant (683A > C) with ovarian cancer risk in BRCA1 mutation carriers.
Dick MG, Versmold B, Engel C, Meindl A, Arnold N, Varon-Mateeva R, Sutter C, Niederacher D, Deissler H, Preisler-Adams S, Kast K, Schäfer D, Gadzicki D, Heinritz W, Wappenschmidt B, Schmutzler RK.
Int J Cancer. 2012 Mar 15. Epub 2011 May 30.

Treatment of chemotherapy resistant ovarian cancer with a MDR1 targeted oncolytic adenovirus.
Rein DT, Volkmer A, Beyer IM, Curiel DT, Janni W, Dragoi A, Hess AP, Maass N, Baldus SE, Bauerschmitz G, Breidenbach M.
Gynecol Oncol. 2011 Oct. Epub 2011 Jul 13.

Expression of the Wnt antagonist DKK3 is frequently suppressed in sporadic epithelial ovarian cancer.
You A, Fokas E, Wang LF, He H, Kleb B, Niederacher D, Engenhart-Cabillic R, An HX.
J Cancer Res Clin Oncol. 2011 Apr. Epub 2010 Jun 9.

Economic burden of vulvar and vaginal intraepithelial neoplasia: retrospective cost study at a German dysplasia centre.
Hampl M, Huppertz E, Schulz-Holstege O, Kok P, Schmitter S.
BMC Infect Dis. 2011 Mar 22.

Analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity.
Strauss R, Li ZY, Liu Y, Beyer I, Persson J, Sova P, Möller T, Pesonen S, Hemminki A, Hamerlik P, Drescher C, Urban N, Bartek J, Lieber A.
PLoS One. 2011 Jan 14. Erratum in: PLoS One. 2011.

The risk of urinary incontinence after partial urethral resection in patients with anterior vulvar cancer.
Hampl M, Langkamp B, Lux J, Kueppers V, Janni W, Müller-Mattheis V.
Eur J Obstet Gynecol Reprod Biol. 2011 Jan. Epub 2010 Sep 29.

Ausgewählte Publikationen zu Hauttumoren


Vemurafenib Potently Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in BRAFV600E Melanoma Cells.

Beck D, Niessner H, Smalley KS, Flaherty K, Paraiso KH, Busch C, Sinnberg T, Vasseur S, Iovanna JL, Drießen S, Stork B, Wesselborg S, Schaller M, Biedermann T, Bauer J, Lasithiotakis K, Weide B, Eberle J, Schittek B, Schadendorf D, Garbe C, Kulms D, Meier F.
Sci Signal. 2013 Jan 29;

MicroRNA-125b down-regulates matrix metallopeptidase 13 and inhibits cutaneous squamous cell carcinoma cell proliferation, migration, and invasion.
Xu N, Zhang L, Meisgen F, Harada M, Heilborn J, Homey B, Grandér D, Ståhle M, Sonkoly E, Pivarcsi A.
J Biol Chem. 2012 Aug 24; Epub 2012 Jul 10.

[Epithelioid sarcoma of the right hand].
Hoff NP, Reifenberger J, Schulte KW, Hanneken S.
Hautarzt. 2012 Apr;

MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma.
Sonkoly E, Lovén J, Xu N, Meisgen F, Wei T, Brodin P, Jaks V, Kasper M, Shimokawa T, Harada M, Heilborn J, Hedblad MA, Hippe A, Grandér D, Homey B, Zaphiropoulos PG, Arsenian-Henriksson M, Ståhle M, Pivarcsi A.
Oncogenesis. 2012 Mar 12;

[Merkel cell carcinoma. Viral genesis and new therapeutic options?].
Pippirs U, Buhren BA, Hoff NP, Gerber PA, Bruch-Gerharz D, Reifenberger J, Homey B, Schulte KW.
Hautarzt. 2009 Apr; Review. German.

[Subungual squamous cell carcinoma. An important differential diagnosis of subungual tumors].
Wessendorf U, Bruch-Gerharz D, Homey B, Schulte KW.
Hautarzt. 2009 Apr; German.

[Treatment of carcinoma in situ of erythema ab igne with photodynamic therapy].
Kochs C, Hanneken S, Schulte KW, Reifenberger J.
Hautarzt. 2008 Oct; German.

[Pilomatrixoma. An important differential diagnosis of cystic tumors in adults].
Grieb S, Eigelshoven S, Schulte KW, Bruch-Gerharz D.
Hautarzt. 2008 Apr; German. No abstract available.

Ausgewählte Publikationen zu Hirntumoren


Response assessment of bevacizumab in patients with recurrent malignant glioma using [18F]Fluoroethyl-L-tyrosine PET in comparison to MRI.

Galldiks N, Rapp M, Stoffels G, Fink GR, Shah NJ, Coenen HH, Sabel M, Langen KJ.
Eur J Nucl Med Mol Imaging. 2013 Jan. Epub 2012 Sep 29.

Primary spinal marginal zone lymphoma: case report and review of the literature.
Ahmadi SA, Frank S, Hänggi D, Eicker SO. 
Neurosurgery. 2012 Aug

Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro.
Dittmann LM, Danner A, Gronych J, Wolter M, Stühler K, Grzendowski M, Becker N, Bageritz J, Goidts V, Toedt G, Felsberg J, Sabel MC, Barbus S, Reifenberger G, Lichter P, Tews B.
Oncogene. 2012 Jul 19. Epub 2011 Dec 12.

Is it a glioblastoma? In dubio pro 5-ALA!
Kamp MA, Santacroce A, Zella S, Reichelt DC, Felsberg J, Steiger HJ, Cornelius JF, Sabel M.
Acta Neurochir (Wien). 2012 Jul. Epub 2012 May 11.

Positron emission tomography imaging of meningioma in clinical practice: review of literature and future directions.
Cornelius JF, Langen KJ, Stoffels G, Hänggi D, Sabel M, Jakob Steiger H.
Neurosurgery. 2012 Apr

μMLC-LINAC radiosurgery for intracranial meningiomas of complex shape.
El Majdoub F, Elawady M, Bührle C, El-Khatib M, Hoevels M, Treuer H, Müller RP, Sturm V, Maarouf M.
Acta Neurochir (Wien). 2012 Apr

Long-term tumor control of benign intracranial meningiomas after radiosurgery in a series of 4565 patients.
Santacroce A, Walier M, Régis J, Liščák R, Motti E, Lindquist C, Kemeny A, Kitz K, Lippitz B, Martínez Álvarez R, Pedersen PH, Yomo S, Lupidi F, Dominikus K, Blackburn P, Mindermann T, Bundschuh O, van Eck AT, Fimmers R, Horstmann GA. 
Neurosurgery. 2012 Jan

Modulation of migratory activity and invasiveness of human glioma spheroids following 5-aminolevulinic acid-based photodynamic treatment. Laboratory investigation.
Etminan N, Peters C, Ficnar J, Anlasik S, Bünemann E, Slotty PJ, Hänggi D, Steiger HJ, Sorg RV, Stummer W.
J Neurosurg. 2011 Aug. Epub 2011 Apr 22.

Glioblastoma multiforme of the elderly: the prognostic effect of resection on survival.
Ewelt C, Goeppert M, Rapp M, Steiger HJ, Stummer W, Sabel M.
J Neurooncol. 2011 Jul. Epub 2010 Oct 16.

Molecular signatures classify astrocytic gliomas by IDH1 mutation status.
Toedt G, Barbus S, Wolter M, Felsberg J, Tews B, Blond F, Sabel MC, Hofmann S, Becker N, Hartmann C, Ohgaki H, von Deimling A, Wiestler OD, Hahn M, Lichter P, Reifenberger G, Radlwimmer B.
Int J Cancer. 2011 Mar 1.

Ausgewählte Publikationen zu Kopf-Hals-Tumoren


Cylindroma of head and neck: Review of the literature and report of two rare cases.
Singh DD, Naujoks C, Depprich R, Schulte KW, Jankowiak F, Kübler NR, Handschel J.
J Craniomaxillofac Surg. 2012 Dec 20.  [Epub ahead of print]

Fear of recurrence significantly influences quality of life in oral cancer patients.
Handschel J, Naujoks C, Kübler NR, Krüskemper G.
Oral Oncol. 2012 Dec; Epub 2012 Jul 18

Giant dumbbell-shaped intra- and extracranial nerve schwannoma in a child presenting with glossopharyngeal neuralgia syncope syndrome: a case report and review of the literature.
Sarikaya-Seiwert S, Klenzner T, Schipper J, Steiger HJ, Haenggi D.
J Neurol Surg A Cent Eur Neurosurg. 2013 Jan; Epub 2012 Oct 26. 

Intraoral schwannoma: review of the literature and presentation of a rare case.
Handschel J, Heikaus S, Depprich R, Kübler NR, Yekta SS, Smeets R, Ommerborn M, Naujoks C.
Cranio. 2012 Apr;

Squamous cell carcinomas of the head and neck in Fanconi anemia: risk, prevention, therapy, and the need for guidelines.
Scheckenbach K, Wagenmann M, Freund M, Schipper J, Hanenberg H. 
Klin Padiatr. 2012 Apr; Epub 2012 Apr 13. Review.

Bilateral multifocal Warthin's tumors in upper neck lymph nodes. Report of a case and brief review of the literature.
Naujoks C, Sproll C, Singh DD, Heikaus S, Depprich R, Kübler NR, Handschel J.
Head Face Med. 2012 Apr 3;

CT-scan is a valuable tool to detect mandibular involvement in oral cancer patients.
Handschel J, Naujoks C, Depprich RA, Kübler NR, Kröpil P, Kuhlemann J, Jansen TM, Boeck I, Sproll KC.
Oral Oncol. 2012 Apr; Epub 2011 Dec 11.

Initial experiences with the Amplatzer Vascular Plug 4 for permanent occlusion of the internal carotid artery in the skull base in patients with head and neck tumors.
Macht S, Mathys C, Schipper J, Turowski B.
Neuroradiology. 2012 Jan; Epub 2010 Dec 29.

Cyclin B1 expression and p53 status in squamous cell carcinomas of the head and neck.
Hoffmann TK, Trellakis S, Okulicz K, Schuler P, Greve J, Arnolds J, Bergmann C, Bas M, Lang S, Lehnerdt G, Brandau S, Mattheis S, Scheckenbach K, Finn OJ, Whiteside TL, Sonkoly E.
Anticancer Res. 2011 Oct

Ausgewählte Publikationen zu Leukämien und Lymphomen


Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.

Froebel J, Cadeddu RP, Hartwig S, Bruns I, Wilk CM, Kuendgen A, Fischer JC, Schroeder T, Steidl UG, Germing U, Lehr S, Haas R, Czibere A.
Mol Cell Proteomics. 2013 Feb 4. [Epub ahead of print]

Sequential combination of azacitidine and lenalidomide in del(5q) higher-risk myelodysplastic syndromes or acute myeloid leukemia: a phase I study.
Platzbecker U, Braulke F, Kündgen A, Götze K, Bug G, Schönefeldt C, Shirneshan K, Röllig C, Bornhäuser M, Naumann R, Neesen J, Giagounidis A, Hofmann WK, Ehninger G, Germing U, Haase D, Wermke M. 
Leukemia. 2013 Jan 28. [Epub ahead of print]

Results from a 1-year, open-label, single arm, multi-center trial evaluating the efficacy and safety of oral Deferasirox in patients diagnosed with low and int-1 risk myelodysplastic syndrome (MDS) and transfusion-dependent iron overload.
Nolte F, Höchsmann B, Giagounidis A, Lübbert M, Platzbecker U, Haase D, Lück A, Gattermann N, Taupitz M, Baier M, Leismann O, Junkes A, Schumann C, Hofmann WK, Schrezenmeier H. 
Ann Hematol. 2013 Jan; Epub 2012 Oct 17.

Nilotinib in imatinib-resistant or imatinib-intolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study.
Giles FJ, le Coutre PD, Pinilla-Ibarz J, Larson RA, Gattermann N, Ottmann OG, Hochhaus A, Radich JP, Saglio G, Hughes TP, Martinelli G, Kim DW, Novick S, Gillis K, Fan X, Cortes J, Baccarani M, Kantarjian HM.
Leukemia. 2013 Jan; Epub 2012 Jul 5.

Sequential combination of azacitidine and lenalidomide in del(5q) higher-risk myelodysplastic syndromes or acute myeloid leukemia: a phase I study.
Platzbecker U, Braulke F, Kündgen A, Götze K, Bug G, Schönefeldt C, Shirneshan K, Röllig C, Bornhäuser M, Naumann R, Neesen J, Giagounidis A, Hofmann WK, Ehninger G, Germing U, Haase D, Wermke M.
Leukemia. 2013 Jan 28.  [Epub ahead of print]

Second cancers and residual disease in patients treated for gastric mucosa-associated lymphoid tissue lymphoma by Helicobacter pylori eradication and followed for 10 years.
Wündisch T, Dieckhoff P, Greene B, Thiede C, Wilhelm C, Stolte M, Neubauer A.
Gastroenterology. 2012 Oct; Epub 2012 Jun 27.

Hematologic responses to deferasirox therapy in transfusion-dependent patients with myelodysplastic syndromes.
Gattermann N, Finelli C, Della Porta M, Fenaux P, Stadler M, Guerci-Bresler A, Schmid M, Taylor K, Vassilieff D, Habr D, Marcellari A, Roubert B, Rose C.
Haematologica. 2012 Sep; Epub 2012 Mar 14.

Improved survival in MDS patients receiving iron chelation therapy - a matched pair analysis of 188 patients from the Düsseldorf MDS registry.
Neukirchen J, Fox F, Kündgen A, Nachtkamp K, Strupp C, Haas R, Germing U, Gattermann N.
Leuk Res. 2012 Aug; Epub 2012 May 6.

Evaluation of dysplasia through detailed cytomorphology in 3156 patients from the Düsseldorf Registry on myelodysplastic syndromes
Germing U, Strupp C, Giagounidis A, Haas R, Gattermann N, Starke C, Aul C.
Leuk Res. 2012 Jun; Epub 2012 Mar 13.

Diagnosis and therapy of myelodysplastic syndromes in Germany: a retrospective multicenter analysis.
Gattermann N, Kündgen A, Kellermann L, Zeffel M, Paessens B, Germing U.
Onkologie. 2012; Epub 2012 May 25

Ausgewählte Publikationen zu Urologischen Tumoren

DNA methylation signatures for prediction of biochemical recurrence after radical prostatectomy of clinically localized prostate cancer.
Haldrup C, Mundbjerg K, Vestergaard EM, Lamy P, Wild P, Schulz WA, Arsov C, Visakorpi T, Borre M, Høyer S, Orntoft TF, Sørensen KD.
J Clin Oncol. 2013 Sep 10; Epub 2013 Aug 5.

Association of PITX2 mRNA down-regulation in prostate cancer with promoter hypermethylation and poor prognosis.
Vinarskaja A, Schulz WA, Ingenwerth M, Hader C, Arsov C.
Urol Oncol. 2013 Jul; Epub 2011 Jul 30.
Time from prior chemotherapy enhances prognostic risk grouping in the second-line setting of advanced urothelial carcinoma: a retrospective analysis of pooled, prospective phase 2 trials.

Sonpavde G, Pond GR, Fougeray R, Choueiri TK, Qu AQ, Vaughn DJ, Niegisch G, Albers P, James ND, Wong YN, Ko YJ, Sridhar SS, Galsky MD, Petrylak DP, Vaishampayan UN, Khan A, Vogelzang NJ, Beer TM, Stadler WM, O'Donnell PH, Sternberg CN, Rosenberg JE, Bellmunt J.
Eur Urol. 2013 Apr; Epub 2012 Nov 26.

Tumor marker kinetics predict outcome in patients with relapsed disseminated non-seminomatous germ-cell tumors.
Massard C, Kramar A, Beyer J, Hartmann JT, Lorch A, Pico JL, Rosti G, Droz JP, Fizazi K.
Ann Oncol. 2013 Feb; Epub 2012 Oct 26.

Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer.
Jones R, Vuky J, Elliott T, Mead G, Arranz JA, Chester J, Chowdhury S, Dudek AZ, Müller-Mattheis V, Grimm MO, Gschwend JE, Wülfing C, Albers P, Li J, Osmukhina A, Skolnik J, Hudes G.
Invest New Drugs. 2013 Jan 18. [Epub ahead of print]

Management of favorable-risk patients with metastatic renal cell carcinoma: when to start and when to stop targeted therapy.
Powles T, Albers P.
Clin Genitourin Cancer. 2012 Dec; Epub 2012 Aug 30.

Contemporary management of postchemotherapy testis cancer.
Daneshmand S, Albers P, Fosså SD, Heidenreich A, Kollmannsberger C, Krege S, Nichols C, Oldenburg J, Wood L.
Eur Urol. 2012 Nov; Epub 2012 Aug 20.

Cabazitaxel Plus Prednisone for Metastatic Castration-resistant Prostate Cancer Progressing After Docetaxel: Results from the German Compassionate-use Programme.
Heidenreich A, Scholz HJ, Rogenhofer S, Arsov C, Retz M, Müller SC, Albers P, Gschwend J, Wirth M, Steiner U, Miller K, Heinrich E, Trojan L, Volkmer B, Honecker F, Bokemeyer C, Keck B, Otremba B, Ecstein-Fraisse E, Pfister D.
Eur Urol. 2012 Sep 3.  [Epub ahead of print]

The role of residual tumor resection in the management of nonseminomatous germ cell cancer of testicular origin.
Schirren J, Trainer S, Eberlein M, Lorch A, Beyer J, Bölükbas S.
Thorac Cardiovasc Surg. 2012 Sep; Epub 2012 Mar 1.

The SNP rs6441224 influences transcriptional activity and prognostically relevant hypermethylation of RARRES1 in prostate cancer.
Kloth M, Goering W, Ribarska T, Arsov C, Sorensen KD, Schulz WA.
Int J Cancer. 2012 Sep; Epub 2012 May 30.

Hedgehog signaling regulates bladder cancer growth and tumorigenicity.
Fei DL, Sanchez-Mejias A, Wang Z, Flaveny C, Long J, Singh S, Rodriguez-Blanco J, Tokhunts R, Giambelli C, Briegel KJ, Schulz WA, Gandolfi AJ, Karagas M, Zimmers TA, Jorda M, Bejarano P, Capobianco AJ, Robbins DJ.
Cancer Res. 2012 Sep 1;72(17):4449-58. Epub 2012 Jul 19.

Discovery of TP53 splice variants in two novel papillary urothelial cancer cell lines.
Koch A, Hatina J, Rieder H, Seifert HH, Huckenbeck W, Jankowiak F, Florl AR, Stoehr R, Schulz WA.
Cell Oncol (Dordr). 2012 Aug; Epub 2012 Jun 6.

Changes in histone deacetylase (HDAC) expression patterns and activity of HDAC inhibitors in urothelial cancers
Niegisch G, Knievel J, Koch A, Hader C, Fischer U, Albers P, Schulz WA.
Urol Oncol. 2012 Aug 31. [Epub ahead of print]

Sequential versus single high-dose chemotherapy in patients with relapsed or refractory germ cell tumors: long-term results of a prospective randomized trial.
Lorch A, Kleinhans A, Kramar A, Kollmannsberger CK, Hartmann JT, Bokemeyer C, Rick O, Beyer J.
J Clin Oncol. 2012 Mar 10; Epub 2012 Jan 30.

Repeat transrectal ultrasound biopsies with additional targeted cores according to results of functional prostate MRI detects high-risk prostate cancer in patients with previous negative biopsy and increased PSA - a pilot study
Arsov C, Quentin M, Rabenalt R, Antoch G, Albers P, Blondin D.
Anticancer Res. 2012 Mar;

Ausgewählte Publikationen zu Tumoren bei Kindern


Minimal residual disease after induction is the strongest predictor of prognosis in intermediate risk relapsed acute lymphoblastic leukaemia - Long-term results of trial ALL-REZ BFM P95/96.
Eckert C, von Stackelberg A, Seeger K, Groeneveld TW, Peters C, Klingebiel T, Borkhardt A, Schrappe M, Escherich G, Henze G.
Eur J Cancer. 2013 Apr; Epub 2012 Dec 19.

Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia.
Chen C, Bartenhagen C, Gombert M, Okpanyi V, Binder V, Röttgers S, Bradtke J, Teigler-Schlegel A, Harbott J, Ginzel S, Thiele R, Fischer U, Dugas M, Hu J, Borkhardt A. 
Genes Chromosomes Cancer. 2013 Mar 18. [Epub ahead of print]

MicroRNAs distinguish cytogenetic subgroups in pediatric AML and contribute to complex regulatory networks in AML-relevant pathways.
Daschkey S, Röttgers S, Giri A, Bradtke J, Teigler-Schlegel A, Meister G, Borkhardt A, Landgraf P.
PLoS One. 2013; Epub 2013 Feb 13.

Recurrent involvement of ring-type zinc finger genes in complex molecular rearrangements in childhood acute myelogeneous leukemia with translocation t(10;11)(p12;q23).
Ghosh S, Bartenhagen C, Okpanyi V, Gombert M, Binder V, Teigler-Schlegel A, Bradtke J, Röttgers S, Dugas M, Borkhardt A.
Leukemia. 2013 Jan 9; Epub ahead of print

EPCAM-A novel molecular target for the treatment of pediatric and adult germ cell tumors.
Schönberger S, Okpanyi V, Calaminus G, Heikaus S, Leuschner I, Nicholson JC, Stoecklein NH, Schneider DT, Borkhardt A.
Genes Chromosomes Cancer. 2013 Jan; Epub 2012 Sep 14.

Allo-SCT using BU, CY and melphalan for children with AML in second CR.
Beier R, Albert MH, Bader P, Borkhardt A, Creutzig U, Eyrich M, Ehlert K, Gruhn B, Greil J, Handgretinger R, Holter W, Klingebiel T, Kremens B, Lang P, Mauz-Körholz C, Meisel R, Müller I, Peters C, Reinhardt D, Sedlacek P, Schulz A, Schuster FR, Schrauder A, Strahm B, Sykora KW, Wössmann W, Zimmermann M, Sauer MG.
Bone Marrow Transplant. 2012 Oct 29; Epub ahead of print

Homeobox protein HB9 binds to the prostaglandin E receptor 2 promoter and inhibits intracellular cAMP mobilization in leukemic cells.
Wildenhain S, Ingenhag D, Ruckert C, Degistirici Ö, Dugas M, Meisel R, Hauer J, Borkhardt A.
J Biol Chem. 2012 Nov 23; Epub 2012 Oct 8.

Evaluation of the prognostic meaning of C-reactive protein (CRP) in children and adolescents with classical Hodgkin's lymphoma (HL).
Haase R, Vilser C, Mauz-Körholz C, Hasenclever D, Kluge R, Ruschke K, Borkhardt A, Seeger K, Lehrnbecher T, Kulozik A, Rößler J, Burdach S, Jürgens H, Körholz D.
Klin Padiatr. 2012 Oct; Epub 2012 Oct 9.

Lack of association between KIR genes and acute lymphoblastic leukemia in children.
Babor F, Manser A, Schönberg K, Enczmann J, Borkhardt A, Meisel R, Uhrberg M.
Blood. 2012 Sep 27;

Invasive aspergillosis in pediatric oncology patients: a rare event with poor prognosis--case analysis to plan better targeted prophylactic or therapeutic measurement.
Babor F, Schuster F, Mackenzie C, Meisel R, Schaper J, Sabir H, Siepermann M, Wessalowski R, Janßen G, Borkhardt A, Laws HJ.
Klin Padiatr. 2012 Apr; Epub 2012 Apr 13.

Ausgewählte Publikationen zu weiteren onkologischen Themen


The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21WAF1/CIP1.
Neise D, Sohn D, Stefanski A, Goto H, Inagaki M, Wesselborg S, Budach W, Stühler K, Jänicke RU.
Cell Death Dis. 2013 Oct 17. [Epub ahead of print]
PDK1 controls upstream PI3K expression and PIP3 generation.

Dieterle AM, Böhler P, Keppeler H, Alers S, Berleth N, Drießen S, Hieke N, Pietkiewicz S, Löffler AS, Peter C, Gray A, Leslie NR, Shinohara H, Kurosaki T, Engelke M, Wienands J, Bonin M, Wesselborg S, Stork B.
Oncogene. 2013 Jul 29. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23362240

Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells.
Beck D, Niessner H, Smalley KS, Flaherty K, Paraiso KH, Busch C, Sinnberg T, Vasseur S, Iovanna JL, Drießen S, Stork B, Wesselborg S, Schaller M, Biedermann T, Bauer J, Lasithiotakis K, Weide B, Eberle J, Schittek B, Schadendorf D, Garbe C, Kulms D, Meier F.
Sci Signal. 2013 Jan 29;

Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1.
Manns J, Daubrawa M, Driessen S, Paasch F, Hoffmann N, Löffler A, Lauber K, Dieterle A, Alers S, Iftner T, Schulze-Osthoff K, Stork B, Wesselborg S.
FASEB J. 2011 Sep;

Dual antitumour effect of 5-azacytidine by inducing a breakdown of resistance-mediating factors and epigenetic modulation.
Venturelli S, Berger A, Weiland T, Zimmermann M, Häcker S, Peter C, Wesselborg S, Königsrainer A, Weiss TS, Gregor M, Fulda S, Lauer UM, Bitzer M.
Gut. 2011 Feb; Epub 2010 Nov 23.

Cutaneous papillomavirus E6 proteins must interact with p300 and block p53-mediated apoptosis for cellular immortalization and tumorigenesis.
Muench P, Probst S, Schuetz J, Leiprecht N, Busch M, Wesselborg S, Stubenrauch F, Iftner T. 
Cancer Res. 2010 Sep 1;

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