Ausgewählte Publikationen zu Bauchtumoren

Serum microRNA profiles as prognostic/predictive markers in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction
Odenthal M, Hee J, Gockel I, Sisic L, Schmitz J, Stoecklein NH, Driemel C, Möhlendick B, Schmidt T, Knoefel WT, Lang H, Büttner R, Ott K, Vallböhmer D.
Int J Cancer. 2014 Nov 27

Integrin expression in esophageal squamous cell carcinoma: loss of the physiological integrin expression pattern correlates with disease progression

Vay C, Hosch SB, Stoecklein NH, Klein CA, Vallböhmer D, Link BC, Yekebas EF, Izbicki JR, Knoefel WT, Scheunemann P.
PLoS One. 2014 Nov 14;9(11):e109026
A case of lethal spontaneous massive hemothorax in a patient with neurofibromatosis 1
Föhrding LZ, Sellmann T, Angenendt S, Kindgen-Milles D, Topp SA, Korbmacher B, Lichtenberg A, Knoefel WT.
J Cardiothorac Surg. 2014 Oct 29;9:172
Surgical strategies in the therapy of non-small cell lung cancer
Al-Shahrabani F, Vallböhmer D, Angenendt S, Knoefel WT.
World J Clin Oncol. 2014 Oct 10;5(4):595-603
Management of early asymptomatic gastrointestinal stromal tumors of the stomach
Scherübl H, Faiss S, Knoefel WT, Wardelmann E.
World J Gastrointest Endosc. 2014 Jul 16;6(7):266-71.
Cervical compression due to benign thyroid disorders is not associated with increased postoperative morbidity
Ambe P1, Lindecke K, Knoefel WT, Rehders A.
Eur Arch Otorhinolaryngol. 2014 Jul 17
Circulating tumor cells in patients with neuroendocrine neoplasms
Ehlers M, Allelein S, Haase M, Willenberg HS, Knoefel WT, Schott M.
Horm Metab Res. 2014 Sep;46(10):744-5

Endoscopic treatment of anastomotic leakage after esophagectomy or gastrectomy for carcinoma with self-expanding removable stents

Alldinger I, Schmitt MM, Dreesbach J, Knoefel WT.
Hepatogastroenterology. 2014 Jan-Feb;61(129):111-4.
Clinically staged cT2 adenocarcinomas of the gastroesophageal junction: accuracy of staging and therapeutic consequences
Vallböhmer D, Sisic L, Blank S, Kraus S, Stoecklein NH, Knoefel WT, Büchler MW, Ott K.
Oncol Res Treat. 2014;37(3):97-104
Multimodal treatment of hepatocellular carcinoma
Graf D, Vallböhmer D, Knoefel WT, Kröpil P, Antoch G, Sagir A, Häussinger D.
Eur J Intern Med. 2014 Jun;25(5):430-7.
New model for gastroenteropancreatic large-cell neuroendocrine carcinoma: establishment of two clinically relevant cell lines
Krieg A, Mersch S, Boeck I, Dizdar L, Weihe E, Hilal Z, Krausch M, Möhlendick B, Topp SA, Piekorz RP, Huckenbeck W, Stoecklein NH, Anlauf M, Knoefel WT.
PLoS One. 2014 Feb 14;9(2):e88713.
Context-dependent adaption of EpCAM expression in early systemic esophageal cancer
Driemel C, Kremling H, Schumacher S, Will D, Wolters J, Lindenlauf N, Mack B, Baldus SA, Hoya V, Pietsch JM, Panagiotidou P, Raba K, Vay C, Vallböhmer D, Harréus U, Knoefel WT, Stoecklein NH, Gires O.
Oncogene. 2014 Oct 9;33(41):4904-15
"Cherry picking", a multiple non-anatomic liver resection technique, as a promising option for diffuse liver metastases in patients with neuroendocrine tumours
Krausch M, Raffel A, Anlauf M, Schott M, Lehwald N, Krieg A, Topp SA, Cupisti K, Knoefel WT.
World J Surg. 2014 Feb;38(2):392-401
How radical should the surgical therapy for gastric/cardia cancer be
Vallböhmer D, Knoefel WT.
Zentralbl Chir. 2014 Feb;139(1):23-7.
Analysis of Copy-Number Alterations in Single Cells Using Microarray-Based Comparative Genomic Hybridization (aCGH)
Möhlendick B, Stoecklein NH.
Curr Protoc Cell Biol. 2014 Dec 1;65:22.19.1-22.19.23.
Genomic high-resolution profiling of single CKpos/CD45neg flow-sorting purified circulating tumor cells from patients with metastatic breast cancer
Neves RP, Raba K, Schmidt O, Honisch E, Meier-Stiegen F, Behrens B, Möhlendick B, Fehm T, Neubauer H, Klein CA, Polzer B, Sproll C, Fischer JC, Niederacher D, Stoecklein NH.
Clin Chem. 2014 Oct;60(10):1290-7.
Dynamic EpCAM expression on circulating and disseminating tumor cells: causes and consequences
Gires O1, Stoecklein NH.
Cell Mol Life Sci. 2014 Nov;71(22):4393-402.
A new workflow for whole-genome sequencing of single human cells
Binder V, Bartenhagen C, Okpanyi V, Gombert M, Moehlendick B, Behrens B, Klein HU, Rieder H, Ida Krell PF, Dugas M, Stoecklein NH, Borkhardt A.
Hum Mutat. 2014 Oct;35(10):1260-70.
Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer
Steinert G, Schölch S, Niemietz T, Iwata N, García SA, Behrens B, Voigt A, Kloor M, Benner A, Bork U, Rahbari NN, Büchler MW, Stoecklein NH, Weitz J, Koch M.
Cancer Res. 2014 Mar 15;74(6):1694-704.
Hepatic stellate cells contribute to progenitor cells and liver regeneration
Kordes C, Sawitza I, Götze S, Herebian D, Häussinger D.
J Clin Invest. 2014 Dec;124(12):5503-15.
T-cell STAT3 is required for the maintenance of humoral immunity to LCMV
McIlwain DR1, Grusdat M, Pozdeev VI, Xu HC, Shinde P, Reardon C, Hao Z, Beyer M, Bergthaler A, Häussinger D, Nolan GP, Lang KS, Lang PA.
Eur J Immunol. 2015 Feb;45(2):418-27.
TACE plus sorafenib for the treatment of hepatocellular carcinoma: results of the multicenter, phase II SOCRATES trial
Erhardt A, Kolligs F, Dollinger M, Schott E, Wege H, Bitzer M, Gog C, Lammert F, Schuchmann M, Walter C, Blondin D, Ohmann C, Häussinger D.
Cancer Chemother Pharmacol. 2014 Nov;74(5):947-54.

Ausgewählte Publikationen zu Brustkrebs

Evaluation of Therapy Management and Patient Compliance in Postmenopausal Patients with Hormone Receptor-positive Breast Cancer Receiving Letrozole Treatment: The EvaluateTM Study

Fasching PA, Fehm T, Kellner S, de Waal J, Rezai M, Baier B, Baake G, Kolberg HC.

Geburtshilfe Frauenheilkd. 2014 Dec;74(12):1137-1143.


Molecular Markers as Prognostic Factors in DCIS and Small Invasive Breast Cancers

Sänger N, Engels K, Graf A, Ruckhäberle E, Effenberger KE, Fehm T, Holtrich U, Becker S, Karn T.

Geburtshilfe Frauenheilkd. 2014 Nov;74(11):1016-1022


Survival after neoadjuvant chemotherapy with or without bevacizumab or everolimus for HER2-negative primary breast cancer (GBG 44-GeparQuinto)

von Minckwitz G, Loibl S, Untch M, Eidtmann H, Rezai M, Fasching PA, Tesch H, Eggemann H, Schrader I, Kittel K, Hanusch C, Huober J, Solbach C, Jackisch C, Kunz G, Blohmer JU, Hauschild M, Fehm T, Nekljudova V, Gerber B.

Ann Oncol. 2014 Dec;25(12):2363-72


Targeted and Osteo-Oncologic Treatment in Early Breast Cancer: What Is State-of-the-Art and What Might Become so within the Next 5 Years?

Stickeler E, Fehm T.

Breast Care (Basel). 2014 Jul;9(3):161-7


Expression of stem cell and epithelial-mesenchymal transition markers in circulating tumor cells of breast cancer patients

Krawczyk N, Meier-Stiegen F, Banys M, Neubauer H, Ruckhaeberle E, Fehm T.

Biomed Res Int. 2014;2014:415721


Prognostic relevance of induced and spontaneous apoptosis of disseminated tumor cells in primary breast cancer patients

Krawczyk N, Hartkopf A, Banys M, Meier-Stiegen F, Staebler A, Wallwiener M, Röhm C, Hoffmann J, Hahn M, Fehm T.

BMC Cancer. 2014 Jun 3;14:394


Circulating tumor cells predict survival in early average-to-high risk breast cancer patients

Rack B, Schindlbeck C, Jückstock J, Andergassen U, Hepp P, Zwingers T, Friedl TW, Lorenz R, Tesch H, Fasching PA, Fehm T, Schneeweiss A, Lichtenegger W, Beckmann MW2, Friese K, Pantel K, Janni W.

J Natl Cancer Inst. 2014 May 15;106(5)


Monitoring in metastatic breast cancer: is imaging outdated in the era of circulating tumor cells?
Alunni-Fabbroni M, Müller V, Fehm T, Janni W, Rack B.
Breast Care (Basel). 2014 Feb;9(1):16-21
OPG and PgR show similar cohort specific effects as prognostic factors in ER positive breast cancer
Sänger N, Ruckhäberle E, Bianchini G, Heinrich T, Milde-Langosch K, Müller V, Rody A, Solomayer EF, Fehm T, Holtrich U, Becker S, Karn T.
Mol Oncol. 2014 Oct;8(7):1196-207
Sentinel node biopsy and axillary dissection in breast cancer: the evidence and its limits
Janni W, Kühn T, Schwentner L, Kreienberg R, Fehm T, Wöckel A.
Dtsch Arztebl Int. 2014 Apr 4;111(14):244-9
International study on inter-reader variability for circulating tumor cells in breast cancer
Ignatiadis M, Riethdorf S, Bidard FC, Vaucher I, Khazour M, Rothé F, Metallo J, Rouas G, Payne RE, Coombes R, Teufel I, Andergassen U, Apostolaki S, Politaki E, Mavroudis D, Bessi S, Pestrin M, Di Leo A, Campion M, Reinholz M, Perez E, Piccart M, Borgen E, Naume B, Jimenez J, Aura C, Zorzino L, Cassatella M, Sandri M, Mostert B, Sleijfer S, Kraan J, Janni W, Fehm T, Rack B, Terstappen L, Repollet M, Pierga JY, Miller C, Sotiriou C, Michiels S, Pantel K.
Breast Cancer Res. 2014 Apr 23;16(2):R43
The role and clinical relevance of disseminated tumor cells in breast cancer
Banys M, Krawczyk N, Fehm T.
Cancers (Basel). 2014 Jan 15;6(1):143-52

Ausgewählte Publikationen zu Endokrinen Tumoren

Hashimoto's thyroiditis and papillary thyroid cancer: are they immunologically linked?
Ehlers M, Schott M.
Trends Endocrinol Metab. 2014 Dec;25(12):656-64
Best supportive care from the conservative/non-surgical perspective and its costs in the treatment of patients with advanced medullary thyroid cancer: results of a Delphi panel
Kreissl MC, Jacob C, Führer D, Karges W, Luster M, Lux MP, Mann K, Mittendorf T, Schott M, Spitzweg C, Schmoll HJ.
Oncol Res Treat. 2014;37(6):316-22
Thyroglobulin measurement using highly sensitive assays in patients with differentiated thyroid cancer: a clinical position paper
Giovanella L, Clark PM, Chiovato L, Duntas L, Elisei R, Feldt-Rasmussen U, Leenhardt L, Luster M, Schalin-Jäntti C, Schott M, Seregni E, Rimmele H, Smit J, Verburg FA.
Eur J Endocrinol. 2014 Aug;171(2):R33-46
"Cherry picking", a multiple non-anatomic liver resection technique, as a promising option for diffuse liver metastases in patients with neuroendocrine tumours
Krausch M, Raffel A, Anlauf M, Schott M, Lehwald N, Krieg A, Topp SA, Cupisti K, Knoefel WT.
World J Surg. 2014 Feb;38(2):392-401
Post-saline infusion test aldosterone levels indicate severity and outcome in primary aldosteronism
Weigel M, Riester A, Hanslik G, Lang K, Willenberg HS, Endres S, Allolio B, Beuschlein F, Reincke M, Quinkler M.
Eur J Endocrinol. 2015 Apr;172(4):443-50
Aldosterone suppression on contralateral adrenal during adrenal vein sampling does not predict blood pressure response after adrenalectomy
Monticone S, Satoh F, Viola A, Fischer E, Vonend O, Bernini G, Lucatello B, Quinkler M, Ronconi V, Morimoto R, Kudo M, Degenhart C, Gao X, Carrara D, Willenberg HS, Rossato D, Mengozzi G, Riester A, Paci E, Iwakura Y, Burrello J, Maccario M, Giacchetti G, Veglio F, Ito S, Reincke M, Mulatero P. 
J Clin Endocrinol Metab. 2014 Nov;99(11):4158-66

Ausgewählte Publikationen zu Gynäkologischen Tumoren

Circulating and disseminated tumor cells in ovarian cancer: a systematic review
Romero-Laorden N, Olmos D, Fehm T, Garcia-Donas J, Diaz-Padilla I.
Gynecol Oncol. 2014 Jun;133(3):632-9
Detection and clinical relevance of hematogenous tumor cell dissemination in patients with ductal carcinoma in situ
Banys M, Hahn M, Gruber I, Krawczyk N, Wallwiener M, Hartkopf A, Taran FA, Röhm C, Kurth R, Becker S, Solomayer EF, Wallwiener D, Staebler A, Fehm T.
Breast Cancer Res Treat. 2014 Apr;144(3):531-8
Quantitative measurement of melanoma spread in sentinel lymph nodes and survival
Ulmer A, Dietz K, Hodak I, Polzer B, Scheitler S, Yildiz M, Czyz Z, Lehnert P, Fehm T, Hafner C, Schanz S, Röcken M, Garbe C, Breuninger H, Fierlbeck G, Klein CA.
PLoS Med. 2014 Feb 18;11(2):e1001604
Feasibility and first long-term results after laparoscopic rectal segment resection and vaginal specimen retrieval for deep infiltrating endometriosis
Fleisch MC, Hepp P, Kaleta T, Schulte Am Esch J, Rein D, Fehm T, Beyer I.
Arch Gynecol Obstet. 2014 Jun;289(6):1241-7
Elevated lipoprotein(a) levels and homozygous human platelet antigen 1b (HPA-1b) genotype are risk factors for intrauterine growth restriction (IUGR)
Gerhardt A1, Howe N, Krüssel JS, Scharf RE, Zotz RB.
J Thromb Thrombolysis. 2014;37(2):107-17.
Macrophage capping protein CapG is a putative oncogene involved in migration and invasiveness in ovarian carcinoma
Glaser J, Neumann MH, Mei Q, Betz B, Seier N, Beyer I, Fehm T, Neubauer H, Niederacher D, Fleisch MC.
Biomed Res Int. 2014;2014:379847
Molecular profiling of single circulating tumor cells with diagnostic intention
Polzer B, Medoro G, Pasch S, Fontana F, Zorzino L, Pestka A, Andergassen U, Meier-Stiegen F, Czyz ZT, Alberter B, Treitschke S, Schamberger T, Sergio M, Bregola G, Doffini A, Gianni S, Calanca A, Signorini G, Bolognesi C, Hartmann A, Fasching PA, Sandri MT, Rack B, Fehm T, Giorgini G, Manaresi N, Klein CA.
EMBO Mol Med. 2014 Oct 30;6(11):1371-86

Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors

Goh G, Scholl UI, Healy JM, Choi M, Prasad ML, Nelson-Williams C, Kunstman JW, Korah R, Suttorp AC, Dietrich D, Haase M, Willenberg HS, Stalberg P, Hellman P, Akerström G, Björklund P, Carling T, Lifton RP.
Nat Genet. 2014 Jun;46(6):613-7
Less common genotype variants of TP53 polymorphisms are associated with poor outcome in adult patients with adrenocortical carcinoma
Heinze B, Herrmann LJ, Fassnacht M, Ronchi CL, Willenberg HS, Quinkler M, Reisch N, Zink M, Allolio B, Hahner S.
Eur J Endocrinol. 2014 Apr 10;170(5):707-17

Ausgewählte Publikationen zu Hauttumoren

A novel therapeutic strategy for turban tumor: scalp excision and combined reconstruction with artificial dermis and split skin graft
Parren LJ, Ferdinandus P, van der Hulst R, Frank J, Tuinder S.
Int J Dermatol. 2014 Feb;53(2):246-9
Growth and metastasis of B16-F10 melanoma cells is not critically dependent on host CD73 expression in mice
Burghoff S, Gong X, Viethen C, Jacoby C, Flögel U, Bongardt S, Schorr A, Hippe A, Homey B, Schrader J
BMC Cancer. 2014 Dec 2;14:898

Ausgewählte Publikationen zu Hirntumoren

Diagnosis of pseudoprogression in patients with glioblastoma using O-(2-[18F]fluoroethyl)-L-tyrosine PET
Galldiks N1, Dunkl V, Stoffels G, Hutterer M, Rapp M, Sabel M, Reifenberger G, Kebir S, Dorn F, Blau T, Herrlinger U, Hau P, Ruge MI, Kocher M, Goldbrunner R, Fink GR, Drzezga A, Schmidt M, Langen KJ. Eur J Nucl Med Mol Imaging. 2014 Nov 20

A rising trend in use of contralateral prophylactic mastectomy: does the decision to undergo immediate reconstruction play a role?

Agarwal S, Kidwell K, Kraft CT, Kozlow JH, Sabel M, Chung KC, Momoh AO.
Plast Reconstr Surg. 2014 Oct;134(4 Suppl 1):87
Comparison of 18F-FET PET and perfusion-weighted MR imaging: a PET/MR imaging hybrid study in patients with brain tumors
Filss CP1, Galldiks N, Stoffels G, Sabel M, Wittsack HJ, Turowski B, Antoch G, Zhang K, Fink GR, Coenen HH, Shah NJ, Herzog H, Langen KJ.
J Nucl Med. 2014 Apr;55(4):540-5
Glioblastoma multiforme metastasis outside the CNS: three case reports and possible mechanisms of escape
Hamilton JD, Rapp M, Schneiderhan T, Sabel M, Hayman A, Scherer A, Kröpil P, Budach W, Gerber P, Kretschmar U, Prabhu S, Ginsberg LE, Bölke E, Matuschek C.
J Clin Oncol. 2014 Aug 1;32(22):e80-4
Evaluation of post-operative complications associated with repeat resection and BCNU wafer implantation in recurrent glioblastoma
Samis Zella MA, Wallocha M, Slotty PJ, Isik G, Hänggi D, Schroeteler J, Ewelt C, Steiger HJ, Sabel M.
Acta Neurochir (Wien). 2014 Feb;156(2):313-23

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR

Henze AT, Garvalov BK1, Seidel S, Cuesta AM, Ritter M, Filatova A, Foss F, Dopeso H, Essmann CL, Maxwell PH, Reifenberger G, Carmeliet P, Acker-Palmer A, Acker T.
Nat Commun. 2014 Nov 25;5:5582

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts

Waldera-Lupa DM, Kalfalah F, Florea AM, Sass S, Kruse F, Rieder V, Tigges J, Fritsche E, Krutmann J, Busch H, Boerries M, Meyer HE, Boege F, Theis F, Reifenberger G, Stühler K.
Aging (Albany NY). 2014 Oct;6(10):856-78.
How stemlike are sphere cultures from long-term cancer cell lines? Lessons from mouse glioma models
Ahmad M, Frei K, Willscher E, Stefanski A, Kaulich K, Roth P, Stühler K, Reifenberger G, Binder H, Weller M.
J Neuropathol Exp Neurol. 2014 Nov;73(11):1062-77

MicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escape

Codo P, Weller M, Meister G, Szabo E, Steinle A, Wolter M, Reifenberger G, Roth P.
Oncotarget. 2014 Sep 15;5(17):7651-62

EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma

Weller M, van den Bent M, Hopkins K, Tonn JC, Stupp R, Falini A, Cohen-Jonathan-Moyal E, Frappaz D, Henriksson R, Balana C, Chinot O, Ram Z, Reifenberger G, Soffietti R, Wick W.
Lancet Oncol. 2014 Aug;15(9):e395-403

Assessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial

Wiestler B, Capper D, Hovestadt V, Sill M, Jones DT, Hartmann C, Felsberg J, Platten M, Feiden W, Keyvani K, Pfister SM, Wiestler OD, Meyermann R, Reifenberger G, Pietsch T, von Deimling A, Weller M, Wick W.
Neuro Oncol. 2014 Dec;16(12):1630-8

Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma

Wiestler B1, Capper D, Sill M, Jones DT, Hovestadt V, Sturm D, Koelsche C, Bertoni A, Schweizer L, Korshunov A, Weiß EK, Schliesser MG, Radbruch A, Herold-Mende C, Roth P, Unterberg A, Hartmann C, Pietsch T, Reifenberger G, Lichter P, Radlwimmer B, Platten M, Pfister SM, von Deimling A, Weller M, Wick W.
Acta Neuropathol. 2014 Oct;128(4):561-71
MGMT testing--the challenges for biomarker-based glioma treatment
Wick W, Weller M, van den Bent M, Sanson M, Weiler M, von Deimling A, Plass C, Hegi M, Platten M, Reifenberger G.
Nat Rev Neurol. 2014 Jul;10(7):372-85
Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort
Pietsch T, Schmidt R, Remke M, Korshunov A, Hovestadt V, Jones DT, Felsberg J, Kaulich K, Goschzik T, Kool M, Northcott PA, von Hoff K, von Bueren AO, Friedrich C, Mynarek M, Skladny H, Fleischhack G, Taylor MD, Cremer F, Lichter P, Faldum A, Reifenberger G, Rutkowski S, Pfister SM.
Acta Neuropathol. 2014 Jul;128(1):137-49

The hallmarks of fibroblast ageing

Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stühler K, Ventura N, Gundermann S, Boukamp P, Boege F.
Mech Ageing Dev. 2014 Jun;138:26-44
Molecular characterization of long-term survivors of glioblastoma using genome- and transcriptome-wide profiling
Reifenberger G, Weber RG, Riehmer V, Kaulich K, Willscher E, Wirth H, Gietzelt J, Hentschel B, Westphal M, Simon M, Schackert G, Schramm J, Matschke J, Sabel MC, Gramatzki D, Felsberg J, Hartmann C, Steinbach JP, Schlegel U, Wick W, Radlwimmer B, Pietsch T, Tonn JC, von Deimling A, Binder H, Weller M, Loeffler M; German Glioma Network.
Int J Cancer. 2014 Oct 15;135(8):1822-31

Assessment and prognostic significance of the epidermal growth factor receptor vIII mutation in glioblastoma patients treated with concurrent and adjuvant temozolomide radiochemotherapy

Weller M, Kaulich K, Hentschel B, Felsberg J, Gramatzki D, Pietsch T, Simon M, Westphal M, Schackert G, Tonn JC, von Deimling A, Davis T, Weiss WA, Loeffler M, Reifenberger G; German Glioma Network.
Int J Cancer. 2014 May 15;134(10):2437-47

Interferon-β induces loss of spherogenicity and overcomes therapy resistance of glioblastoma stem cells

Happold C, Roth P, Silginer M, Florea AM, Lamszus K, Frei K, Deenen R, Reifenberger G, Weller M.
Mol Cancer Ther. 2014 Apr;13(4):948-61

MiR-328 promotes glioma cell invasion via SFRP1-dependent Wnt-signaling activation

Delic S, Lottmann N, Stelzl A, Liesenberg F, Wolter M, Götze S, Zapatka M, Shiio Y, Sabel MC, Felsberg J, Reifenberger G, Riemenschneider MJ.
Neuro Oncol. 2014 Jan;16(2):179-90
Evaluation of a murine single-blood-injection SAH model
Kamp MA, Dibué M, Sommer C, Steiger HJ, Schneider T, Hänggi D.
PLoS One. 2014 Dec 29;9(12):e114946
Hemodynamic stroke: A rare pitfall in cranio cervical junction surgery
Cornelius JF, Slotty P, El Khatib M, Bostelmann R, Hänggi D, Steiger HJ.
J Craniovertebr Junction Spine. 2014 Jul;5(3):122-4

Stroke in patients with occlusion of the internal carotid artery: options for treatment

Lee JI, Jander S, Oberhuber A, Schelzig H, Hänggi D, Turowski B, Seitz RJ.
Expert Rev Neurother. 2014 Oct;14(10):1153-67

The relation of early hypernatremia with clinical outcome in patients suffering from aneurysmal subarachnoid hemorrhage

Beseoglu K, Etminan N, Steiger HJ, Hänggi D.
Clin Neurol Neurosurg. 2014 Aug;123:164-8

Fluorescence-guided surgery with 5-aminolevulinic acid for resection of brain tumors in children--a technical report

Beez T, Sarikaya-Seiwert S, Steiger HJ, Hänggi D.
Acta Neurochir (Wien). 2014 Mar;156(3):597-604

Open microsurgical tumor excavation and vertebroplasty for metastatic destruction of the second cervical vertebra-outcome in seven cases

Floeth FW, Herdmann J, Rhee S, Turowski B, Krajewski K, Steiger HJ, Eicker SO. 
Spine J. 2014 Dec 1;14(12):3030-7

Ausgewählte Publikationen zu Kopf-Hals-Tumoren

Optical coherence tomography guided laser cochleostomy: towards the accuracy on tens of micrometer scale
Zhang, Pfeiffer T, Weller M, Wieser W, Huber R, Raczkowsky J, Schipper J, Wörn H, Klenzner T.
Biomed Res Int. 2014;2014:251814
Cochlear obliteration after translabyrinthine vestibular schwannoma surgery
Beutner C, Mathys C, Turowski B, Schipper J, Klenzner T.
Eur Arch Otorhinolaryngol. 2014 Jan 11

Good local control by supracricoid partial laryngectomy (SCPL)

Jäckel MC, Scheckenbach K.
Laryngorhinootologie. 2014 Aug;93(8):504-5.

RAD51C--a new human cancer susceptibility gene for sporadic squamous cell carcinoma of the head and neck (HNSCC)

Scheckenbach K, Baldus SE, Balz V, Freund M, Pakropa P, Sproll C, Schäfer KL, Wagenmann M, Schipper J, Hanenberg H5.
Oral Oncol. 2014 Mar;50(3):196-9

Current findings regarding zirconia implants

Depprich R, Naujoks C, Ommerborn M, Schwarz F, Kübler NR, Handschel J.
Clin Implant Dent Relat Res. 2014 Feb;16(1):124-37
Updated S2K AWMF guideline for the diagnosis and follow-up of obstructive sialadenitis--relevance for radiologic imaging
Vogl TJ, Al-Nawas B, Beutner D, Geisthoff U, Gutinas-Lichius O, Naujoks C, Reich R, Schröder U, Sproll C, Teymoortash A, Ußmüller J, Wittekindt C, Zenk J, Fischer S.
Rofo. 2014 Sep;186(9):843-6

Ausgewählte Publikationen zu Leukämien und Lymphomen

Treatment of Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Stem Cell Transplantation with Azacitidine and Donor Lymphocyte Infusions-A Retrospective Multicenter Analysis from the German Cooperative Transplant Study Group
Schroeder T, Rachlis E, Bug G, Stelljes M, Klein S, Steckel NK, Wolf D, Ringhoffer M, Czibere A, Nachtkamp K, Dienst A, Kondakci M, Stadler M, Platzbecker U, Uharek L, Luft T, Fenk R, Germing U, Bornhäuser M, Kröger N, Beelen DW, Haas R, Kobbe G.
Biol Blood Marrow Transplant. 2014 Dec 23
Impact of Di(2-ethylhexyl)phthalate on migration rate of human promyelocytic leukemia cells (HL-60)
Manz P, Cadeddu RP, Wilk M, Fritz B, Haas R, Wenzel F.
Clin Hemorheol Microcirc. 2014;58(1):241-6

The myelodysplastic syndrome-comorbidity index provides additional prognostic information on patients stratified according to the revised international prognostic scoring system

Zipperer E1, Tanha N, Strupp C, Kündgen A, Nachtkamp K, Neukirchen J, Hildebrandt B, Haas R, Gattermann N, Germing U.
Haematologica. 2014 Mar;99(3):e31-2
Refined medullary blast and white blood cell count based classification of chronic myelomonocytic leukemias
Schuler E, Schroeder M, Neukirchen J, Strupp C, Xicoy B, Kündgen A, Hildebrandt B, Haas R, Gattermann N, Germing U.
Leuk Res. 2014 Dec;38(12):1413-9
Minimizing risk of hypomethylating agent failure in patients with higher-risk MDS and practical management recommendations
Santini V, Prebet T, Fenaux P, Gattermann N, Nilsson L, Pfeilstöcker M, Vyas P, List AF.
Leuk Res. 2014 Dec;38(12):1381-91

Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia

Sonnet M, Claus R, Becker N, Zucknick M, Petersen J, Lipka DB, Oakes CC, Andrulis M, Lier A, Milsom MD, Witte T, Gu L, Kim-Wanner SZ1, Schirmacher P, Wulfert M, Gattermann N, Lübbert M, Rosenbauer F, Rehli M, Bullinger L, Weichenhan D, Plass C.
Genome Med. 2014 Apr 30;6(4):34
Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia
Niemeyer CM, Loh ML, Cseh A, Cooper T, Dvorak CC, Chan R, Xicoy B, Germing U, Kojima S, Manabe A, Dworzak M, De Moerloose B, Starý J, Smith OP, Masetti R, Catala A, Bergstraesser E, Ussowicz M, Fabri O, Baruchel A, Cavé H, Zwaan M, Locatelli F, Hasle H, van den Heuvel-Eibrink MM, Flotho C, Yoshimi A.
Haematologica. 2015 Jan;100(1):17-22
Validation of cytogenetic risk groups according to International Prognostic Scoring Systems by peripheral blood CD34+FISH: results from a German diagnostic study in comparison with an international control group
Braulke F, Platzbecker U, Müller-Thomas C, Götze K, Germing U, Brümmendorf TH, Nolte F, Hofmann WK6, Giagounidis AA, Lübbert M, Greenberg PL, Bennett JM, Solé F, Mallo M, Slovak ML, Ohyashiki K, Le Beau MM, Tüchler H, Pfeilstöcker M, Nösslinger T16, Hildebrandt B, Shirneshan K, Aul C, Stauder R, Sperr WR, Valent P, Fonatsch C, Trümper L, Haase D, Schanz J.
Haematologica. 2015 Feb;100(2):205-13
Response to azacitidine is independent of p53 expression in higher-risk myelodysplastic syndromes and secondary acute myeloid leukemia
Müller-Thomas C, Rudelius M, Rondak IC, Haferlach T, Schanz J, Huberle C, Schmidt B, Blaser R, Kremer M, Peschel C, Germing U, Platzbecker U, Götze K.
Haematologica. 2014 Oct;99(10):e179-81

Feedback signals in myelodysplastic syndromes: increased self-renewal of the malignant clone suppresses normal hematopoiesis

Walenda T, Stiehl T, Braun H, Fröbel J, Ho AD, Schroeder T, Goecke TW, Rath B, Germing U, Marciniak-Czochra A, Wagner W. 
PLoS Comput Biol. 2014 Apr 24;10(4):e1003599
Azacitidine in CMML: matched-pair analyses of daily-life patients reveal modest effects on clinical course and survival
Pleyer L, Germing U2, Sperr WR3, Linkesch W4, Burgstaller S5, Stauder R6, Girschikofsky M7, Schreder M, Pfeilstocker M, Lang A, Sliwa T, Geissler D, Schlick K, Placher-Sorko G, Theiler G, Thaler J, Mitrovic M, Neureiter D, Valent P, Greil R.
Leuk Res. 2014 Apr;38(4):475-83
Clinical and functional implications of microRNA mutations in a cohort of 935 patients with myelodysplastic syndromes and acute myeloid leukemia
Thol F, Scherr M, Kirchner A, Shahswar R, Battmer K, Kade S, Chaturvedi A, Koenecke C, Stadler M, Platzbecker U, Thiede C, Schroeder T, Kobbe G, Bug G, Ottmann O, Hofmann WK, Kröger N, Fiedler W, Schlenk R, Döhner K, Döhner H, Krauter J, Eder M, Ganser A, Heuser M. 
Haematologica. 2014 Dec 31

Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation

Schlenk RF, Kayser S, Bullinger L, Kobbe G, Casper J, Ringhoffer M, Held G, Brossart P, Lübbert M, Salih HR, Kindler T, Horst HA, Wulf G, Nachbaur D, Götze K, Lamparter A, Paschka P, Gaidzik VI, Teleanu V, Späth D, Benner A, Krauter J, Ganser A, Döhner H, Döhner K. 
Blood. 2014 Nov 27;124(23):3441-9
Long-term outcome of allogeneic hematopoietic cell transplantation for patients with mycosis fungoides and Sézary syndrome: a European society for blood and marrow transplantation lymphoma working party extended analysis
Duarte RF, Boumendil A, Onida F, Gabriel I, Arranz R, Arcese W, Poiré X, Kobbe G, Narni F, Cortelezzi A, Olavarría E, Schmitz N, Sureda A, Dreger P.
J Clin Oncol. 2014 Oct 10;32(29):3347-8

Low frequency of calreticulin mutations in MDS patients

Heuser M, Panagiota V, Koenecke C, Fehse B, Alchalby H, Badbaran A, Shahswar R, Stadler M, Eder M, Göhring G, Trummer A, Schroeder T, Kobbe G, Thiede C, Platzbecker U, Schlegelberger B, Kroeger N, Ganser A, Thol F.
Leukemia. 2014 Sep;28(9):1933-4

Prognostic effect of calreticulin mutations in patients with myelofibrosis after allogeneic hematopoietic stem cell transplantation

Panagiota V, Thol F, Markus B, Fehse B, Alchalby H, Badbaran A, Lehmann U, Koenecke C, Shahswar R1, Chaturvedi A, Stadler M1, Eder M1, Göhring G5, Koenigsmann M6, Kloos A, Trummer A, Schroeder T, Kobbe G, Thiede C, Platzbecker U, Schlegelberger B, Kreipe HH, Ganser A, Kröger N, Heuser M. 
Leukemia. 2014 Jul;28(7):1552-5

Ausgewählte Publikationen zu Urologischen Tumoren

Poor-prognosis Germ Cell Tumours: Room for Improvement
Albers P.
Eur Urol. 2014 Nov 20

Complete Response as an Intermediate End Point in Patients Receiving Salvage Systemic Therapy for Urothelial Carcinoma

Sonpavde G, Pond GR, Rosenberg JE, Bajorin DF, Regazzi AM, Choueiri TK, Qu AQ, Niegisch G, Albers P, Necchi A, Di Lorenzo G, Fougeray R, Dreicer R, Chen YH, Wong YN, Sridhar SS, Ko YJ, Milowsky MI, Galsky MD, Bellmunt J.
Clin Genitourin Cancer. 2014 Oct 2
False-positive fluorodeoxyglucose positron emission tomography results after chemotherapy in patients with metastatic seminoma
Decoene J, Winter C, Albers P.
Urol Oncol. 2015 Jan;33(1):23.e15-21
Multiple mechanisms mediate resistance to sorafenib in urothelial cancer
Knievel J, Schulz WA, Greife A, Hader C, Lübke T, Schmitz I, Albers P, Niegisch G.
Int J Mol Sci. 2014 Nov 7;15(11):20500-17
Sequential treatment with taxanes and novel anti-androgenic compounds in castration-resistant prostate cancer
Esch L, Schulz WA, Albers P.
Oncol Res Treat. 2014;37(9):492-8
Patient eligibility and trial design for the salvage therapy of advanced urothelial carcinoma
Sonpavde G, Bellmunt J, Rosenberg JE, Regazzi AM, Bajorin DF, Choueiri TK, Qu AQ, Niegisch G, Albers P, Necchi A, Di Lorenzo G, Fougeray R, Wong YN, Sridhar SS1, Ko YJ, Milowsky MI, Galsky MD, Pond GR.
Clin Genitourin Cancer. 2014 Dec;12(6):395-8
MR-sequences for prostate cancer diagnostics: validation based on the PI-RADS scoring system and targeted MR-guided in-bore biopsy
Schimmöller L, Quentin M, Arsov C, Hiester A, Buchbender C, Rabenalt R, Albers P, Antoch G, Blondin D.
Eur Radiol. 2014 Oct;24(10):2582-9

Degarelix as an intermittent androgen deprivation therapy for one or more treatment cycles in patients with prostate cancer

Boccon-Gibod L, Albers P, Morote J, van Poppel H, de la Rosette J, Villers A, Malmberg A, Neijber A, Montorsi F.
Eur Urol. 2014 Oct;66(4):655-63

German second-opinion network for testicular cancer: sealing the leaky pipe between evidence and clinical practice

Zengerling F, Hartmann M, Heidenreich A, Krege S, Albers P, Karl A, Weissbach L, Wagner W, Bedke J, Retz M, Schmelz HU, Kliesch S, Kuczyk M, Winter E, Pottek T, Dieckmann KP, Schrader AJ, Schrader M; GTCSG (German Testicular Cancer Study Group).
Oncol Rep. 2014 Jun;31(6):2477-81
Prognostic value of a cell-cycle progression score in men with prostate cancer managed with active surveillance after MRI-guided prostate biopsy--a pilot study
Arsov C, Jankowiak F, Hiester A, Rabenalt R, Quentin M, Schimmöller L, Blondin D, Antoch G, Albers P.
Anticancer Res. 2014 May;34(5):2459-66.

Six-month progression-free survival as the primary endpoint to evaluate the activity of new agents as second-line therapy for advanced urothelial carcinoma

Agarwal N, Bellmunt J, Maughan BL, Boucher KM, Choueiri TK, Qu AQ, Vogelzang NJ, Fougeray R, Niegisch G, Albers P, Wong YN, Ko YJ, Sridhar SS, Tantravahi SK, Galsky MD, Petrylak DP, Vaishampayan UN, Mehta AN, Beer TM, Sternberg CN, Rosenberg JE, Sonpavde G.
Clin Genitourin Cancer. 2014 Apr;12(2):130-7

A nomogram including baseline prognostic factors to estimate the activity of second-line therapy for advanced urothelial carcinoma

Pond GR, Agarwal N, Bellmunt J, Choueiri TK, Qu A, Fougeray R, Vaughn D, James ND, Salhi Y, Albers P, Niegisch G, Galsky MD, Wong YN, Ko YJ, Stadler WM, O'Donnell PH, Sridhar SS, Vogelzang NJ, Necchi A, Di Lorenzo G, Sternberg CN, Mehta A, Sonpavde G. 
BJU Int. 2014 May;113(5b):E137-43

Prospective randomized double-blind multicentre phase II study comparing gemcitabine and cisplatin plus sorafenib chemotherapy with gemcitabine and cisplatin plus placebo in locally advanced and/or metastasized urothelial cancer: SUSE (AUO-AB 31/05)

Krege S, Rexer H, vom Dorp F, de Geeter P, Klotz T, Retz M, Heidenreich A, Kühn M, Kamradt J, Feyerabend S, Wülfing C, Zastrow S, Albers P, Hakenberg O, Roigas J, Fenner M, Heinzer H, Schrader M.
BJU Int. 2014 Mar;113(3):429-36

Canonical Notch signalling is inactive in urothelial carcinoma

Greife A, Jankowiak S, Steinbring J, Nikpour P, Niegisch G, Hoffmann MJ, Schulz WA.
BMC Cancer. 2014 Aug 29;14:628
Assessing the quality of studies on the diagnostic accuracy of tumor markers
Goebell PJ, Kamat AM, Sylvester RJ, Black P, Droller M, Godoy G, Hudson MA, Junker K, Kassouf W, Knowles MA, Schulz WA, Seiler R, Schmitz-Dräger BJ. 
Urol Oncol. 2014 Oct;32(7):1051-60

Target genes of recurrent chromosomal amplification and deletion in urothelial carcinoma

Weilandt M, Koch A, Rieder H, Deenen R, Schwender H, Niegisch G, Schulz WA.
Cancer Genomics Proteomics. 2014 May-Jun;11(3):141-53
Deregulation of an imprinted gene network in prostate cancer
Ribarska T, Goering W, Droop J, Bastian KM, Ingenwerth M, Schulz WA. 
Epigenetics. 2014 May;9(5):704-17

MTDH/AEG-1 contributes to central features of the neoplastic phenotype in bladder cancer

Nikpour M, Emadi-Baygi M, Fischer U, Niegisch G, Schulz WA, Nikpour P.
Urol Oncol. 2014 Jul;32(5):670-7
Predictive power of the ESUR scoring system for prostate cancer diagnosis verified with targeted MR-guided in-bore biopsy

Schimmöller L, Quentin M, Arsov C, Hiester A, Kröpil P, Rabenalt R, Albers P, Antoch G, Blondin
Eur J Radiol. 2014 Dec;83(12):2103-8

Feasibility of diffusional kurtosis tensor imaging in prostate MRI for the assessment of prostate cancer: preliminary results

Quentin M, Pentang G, Schimmöller L, Kott O, Müller-Lutz A, Blondin D, Arsov C, Hiester A, Rabenalt R, Wittsack HJ.
Magn Reson Imaging. 2014 Sep;32(7):880-5
Hypermethylation of the GABRE~miR-452~miR-224 promoter in prostate cancer predicts biochemical recurrence after radical prostatectomy
Kristensen H, Haldrup C, Strand S, Mundbjerg K, Mortensen MM, Thorsen K, Ostenfeld MS, Wild PJ, Arsov C, Goering W, Visakorpi T, Egevad L, Lindberg J, Grönberg H, Høyer S, Borre M, Ørntoft TF, Sørensen KD.
Clin Cancer Res. 2014 Apr 15;20(8):2169-81
A practice-changing step forward in germ-cell cancer?
Lorch A.
Lancet Oncol. 2014 Dec;15(13):1409-10

First salvage treatment of germ cell tumor patients with bone metastases: retrospective analysis of a large international database

Oing C, Lorch A, Bokemeyer C, Honecker F, Beyer J, Berger LA, Oechsle K. 
J Cancer Res Clin Oncol. 2014 Nov 14 
Personalizing, not patronizing: the case for patient autonomy by unbiased presentation of management options in stage I testicular cancer
Oldenburg J, Aparicio J, Beyer J, Cohn-Cedermark G, Cullen M, Gilligan T, De Giorgi U, De Santis M, de Wit R, Fosså SD, Germà-Lluch JR, Gillessen S, Haugnes HS, Honecker F, Horwich
Ann Oncol. 2014 Nov 6
First salvage treatment in patients with advanced germ cell cancer after cisplatin-based chemotherapy: analysis of a registry of the German Testicular Cancer Study Group (GTCSG)
Berger LA, Bokemeyer C, Lorch A, Hentrich M, Kopp HG, Gauler TC, Beyer J, de Wit M, Mayer F, Boehlke I, Oing C, Honecker F, Oechsle K.
J Cancer Res Clin Oncol. 2014 Jul;140(7):1211-20
Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line
Werminghaus P1, Haase M, Hornsby PJ, Schinner S, Schott M, Malendowicz LK, Lammers BJ, Goretzki PE, Müller-Mattheis V, Markus Giessing, Willenberg HS.
J Steroid Biochem Mol Biol. 2014 Jan;139:7-15
Increased signal intensity of prostate lesions on high b-value diffusion-weighted images as a predictive sign of malignancy
Quentin M, Schimmöller L, Arsov C, Rabenalt R, Antoch G, Albers P, Blondin D.
Eur Radiol. 2014 Jan;24(1):209-13

Limited efficacy of specific HDAC6 inhibition in urothelial cancer cells
Rosik L, Niegisch G, Fischer U, Jung M, Schulz WA, Hoffmann MJ. 
Cancer Biol Ther. 2014 Jun 1;15(6):742-57

Concomitant downregulation of the imprinted genes DLK1 and MEG3 at 14q32.2 by epigenetic mechanisms in urothelial carcinoma
Greife A, Knievel J, Ribarska T, Niegisch G, Schulz WA 
Clin Epigenetics. 2014 Nov 23;6(1):29

Ausgewählte Publikationen zu Tumoren bei Kindern

Immunotherapy with the trifunctional anti-CD20 x anti-CD3 antibody FBTA05 (Lymphomun) in paediatric high-risk patients with recurrent CD20-positive B cell malignancies
Schuster FR, Stanglmaier M, Woessmann W, Winkler B, Siepermann M, Meisel R, Schlegel PG, Hess J, Lindhofer H, Borkhardt A, Buhmann R.
Br J Haematol. 2014 Dec 11

Genetically engineered mouse models of human B-cell precursor leukemias

Hauer J, Borkhardt A, Sánchez-García I, Cobaleda C.
Cell Cycle. 2014;13(18):2836-46
Germline mutations in children with cancer - leopoldina meeting report, september 26, 2014, jesuit monastery merzhausen

Borkhardt A, Welte K2, Olschewski E3, Niemeyer C4.
Klin Padiatr. 2014 Nov;226(6-7):382-4
KIR ligand C2 is associated with increased susceptibility to childhood ALL and confers an elevated risk for late relapse
Babor F, Manser AR, Fischer JC, Scherenschlich N, Enczmann J, Chazara O, Moffett A, Borkhardt A, Meisel R, Uhrberg M.
Blood. 2014 Oct 2;124(14):2248-51
Identification of ITK deficiency as a novel genetic cause of idiopathic CD4+ T-cell lymphopenia
Serwas NK, Cagdas D, Ban SA, Bienemann K, Salzer E, Tezcan I, Borkhardt A, Sanal O, Boztug K.
Blood. 2014 Jul 24;124(4):655-7
Recurrent RHOA mutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols
Rohde M, Richter J, Schlesner M, Betts MJ, Claviez A, Bonn BR, Zimmermann M, Damm-Welk C, Russell RB, Borkhardt A, Eils R, Hoell JI, Szczepanowski M, Oschlies I, Klapper W, Burkhardt B, Siebert R; German ICGC MMML-Seq-Project; NHL-BFM Study Group. 
Genes Chromosomes Cancer. 2014 Nov;53(11):911-6
Osteonecrosis in paediatric patients with acute lymphoblastic leukaemia treated on Co-ALL-07-03 trial: a single centre analysis
Kuhlen M, Moldovan A, Krull K, Meisel R, Borkhardt A.
Klin Padiatr. 2014 May;226(3):154-60
Haploidentical stem cell transplantation in DOCK8 deficiency - Successful control of pre-existing severe viremia with a TCRaß/CD19-depleted graft and antiviral treatment
Ghosh S, Schuster FR, Adams O, Babor F, Borkhardt A, Comoli P, Handgretinger R, Lang P, Laws HJ, Siepermann M, Meisel R.
Clin Immunol. 2014 May-Jun;152(1-2):111-4
Mycoplasma salivarium as a dominant coloniser of Fanconi anaemia associated oral carcinoma
Henrich B, Rumming M, Sczyrba A, Velleuer E, Dietrich R, Gerlach W, Gombert M, Rahn S, Stoye J, Borkhardt A, Fischer U.
PLoS One. 2014 Mar 18;9(3):e92297

Tumoral stem cell reprogramming as a driver of cancer: Theory, biological models, implications in cancer therapy

Vicente-Dueñas C, Hauer J, Ruiz-Roca L, Ingenhag D, Rodríguez-Meira A, Auer F, Borkhardt A, Sánchez-García I.
Semin Cancer Biol. 2014 Feb 12
Efficacy of cyclin-dependent-kinase 9 inhibitors in a murine model of mixed-lineage leukemia
Garcia-Cuellar MP, Füller E, Mäthner E, Breitinger C, Hetzner K, Zeitlmann L, Borkhardt A, Slany RK.
Leukemia. 2014 Jul;28(7):1427-35

CD4(+)and CD8(+)T-cell reactions against leukemia-associated- or minor-histocompatibility-antigens in AML-patients after allogeneic SCT

Steger B, Milosevic S, Doessinger G, Reuther S, Liepert A, Braeu M, Schick J, Vogt V, Schuster F, Kroell T, Busch DH, Borkhardt A, Kolb HJ, Tischer J, Buhmann R, Schmetzer H. Immunobiology. 2014 Apr;219(4):247-60
Inherited susceptibility to pre B-ALL caused by germline transmission of PAX5 c.547G>A
Auer F, Rüschendorf F, Gombert M, Husemann P, Ginzel S, Izraeli S, Harit M, Weintraub M, Weinstein OY, Lerer I, Stepensky P, Borkhardt A, Hauer J. 
Leukemia. 2014 May;28(5):1136-8
Treosulfan-based conditioning regimen for children and adolescents with hemophagocytic lymphohistiocytosis
Lehmberg K, Albert MH, Beier R, Beutel K, Gruhn B, Kröger N, Meisel R, Schulz A, Stachel D, Woessmann W, Janka G, Müller I.
Haematologica. 2014 Jan;99(1):180-4
Lowest numbers of primary CD8(+) T cells can reconstitute protective immunity upon adoptive immunotherapy
Stemberger C, Graef P, Odendahl M, Albrecht J, Dössinger G, Anderl F, Buchholz VR, Gasteiger G5, Schiemann M, Grigoleit GU7, Schuster FR, Borkhardt A, Versluys B, Tonn T, Seifried E, Einsele H, Germeroth L, Busch DH, Neuenhahn M.
Blood. 2014 Jul 24;124(4):628-37
Challenges in the local treatment of large abdominal embryonal rhabdomyosarcoma
Dantonello TM, Lochbühler H, Schuck A, Kube S, Godzinski J, Sköldenberg E, Ljungman G, Kosztyla D, Veit-Friedrich I, Hallmen E, Feuchtgruber S, Wessalowski R, Franke M, Bielack SS, Klingebiel T, Koscielniak E.
Ann Surg Oncol. 2014 Oct;21(11):3579-86

A novel homozygous Fas ligand mutation leads to early protein truncation, abrogation of death receptor and reverse signaling and a severe form of the autoimmune lymphoproliferative syndrome

Nabhani S, Hönscheid A, Oommen PT, Fleckenstein B, Schaper J, Kuhlen M, Laws HJ, Borkhardt A, Fischer U. 
Clin Immunol. 2014 Dec;155(2):231-7

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing
Hovestadt V, Jones DT, Picelli S, Wang W, Kool M, Northcott PA, Sultan M, Stachurski K, Ryzhova M, Warnatz HJ5, Ralser M, Brun S, Bunt J, Jäger N, Kleinheinz K, Erkek S, Weber UD3, Bartholomae CC, von Kalle C, Lawerenz C, Eils J, Koster J, Versteeg R, Milde T, Witt O, Schmidt S, Wolf S, Pietsch T, Rutkowski S, Scheurlen W, Taylor MD, Brors B, Felsberg J, Reifenberger G, Borkhardt A, Lehrach H, Wechsler-Reya RJ, Eils R, Yaspo ML, Landgraf P, Korshunov A, Zapatka M, Radlwimmer B, Pfister SM, Lichter P.
Nature. 2014 Jun 26;510(7506):537-41

Constitutional mismatch repair-deficiency and whole-exome sequencing as the means of the rapid detection of the causative MSH6 defect
Hoell JI, Gombert M, Ginzel S, Loth S, Landgraf P, Käfer V, Streiter M, Prokop A, Weiss M, Thiele R, Borkhardt A.
Klin Padiatr. 2014 Nov;226(6-7):357-61.
Interleukin-2-inducible T-cell kinase (ITK) deficiency - clinical and molecular aspects
Ghosh S, Bienemann K, Boztug K, Borkhardt A.
J Clin Immunol. 2014 Nov;34(8):892-9.
Genomic inverse PCR for exploration of ligated breakpoints (GIPFEL), a new method to detect translocations in leukemia
Fueller E, Schaefer D, Fischer U, Krell PF, Stanulla M, Borkhardt A, Slany RK.
PLoS One. 2014 Aug 19;9(8):e104419. Doi
A new workflow for whole-genome sequencing of single human cells
Binder V, Bartenhagen C, Okpanyi V, Gombert M, Moehlendick B, Behrens B, Klein HU, Rieder H, Ida Krell PF, Dugas M, Stoecklein NH, Borkhardt A.
Hum Mutat. 2014 Oct;35(10):1260-70.
[Palliative home care of children: an opinion survey of orphaned parents]
Kuhlen M, Schlote A, Borkhardt A, Janßen G.
Klin Padiatr. 2014 May;226(3):182-7.
Monitoring of hematopoietic chimerism after transplantation for pediatric myelodysplastic syndrome: real-time or conventional short tandem repeat PCR in peripheral blood or bone marrow?
Willasch AM, Kreyenberg H, Shayegi N, Rettinger E, Meyer V, Zabel M, Lang P, Kremens B, Meisel R, Strahm B, Rossig C, Gruhn B, Klingebiel T, Niemeyer CM, Bader P.
Biol Blood Marrow Transplant. 2014 Dec;20(12):1918-25
Mesenchymal stromal cells in the antimicrobial host response of hematopoietic stem cell recipients with graft-versus-host disease--friends or foes?
Balan A, Lucchini G, Schmidt S, Schneider A, Tramsen L, Kuçi S, Meisel R, Bader P, Lehrnbecher T.
Leukemia. 2014 Oct;28(10):1941-8

Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia

Meissner B, Bartram T, Eckert C, Trka J, Panzer-Grümayer R, Hermanova I, Ellinghaus E, Franke A, Möricke A, Schrauder A, Teigler-Schlegel A, Dörge P, von Stackelberg A, Basso G, Bartram CR, Kirschner-Schwabe R, Bornhäuser B, Bourquin JP, Cazzaniga G, Hauer J, Attarbaschi A, Izraeli S, Zaliova M, Cario G, Zimmermann M, Avigad S, Sokalska-Duhme M, Metzler M, Schrappe M, Koehler R, Te Kronnie G, Stanulla M.
Hum Mol Genet. 2014 Feb 1;23(3):590-601

Significantly increased CD70 up regulation on TEL-AML positive B cell precursor acute lymphoblastic leukemia cells following CD40 stimulation

Troeger A, Glouchkova L, Ackermann B, Escherich G, Hanenberg H, Janka G, Roettgers S, Göbel U, Dilloo D.
Klin Padiatr. 2014 Nov;226(6-7):332-7. doi

Variable correction of Artemis deficiency by I-Sce1-meganuclease-assisted homologous recombination in murine hematopoietic stem cells
Rivière J, Hauer J, Poirot L, Brochet J, Souque P, Mollier K, Gouble A, Charneau P, Fischer A, Pâques F, de Villartay JP, Cavazzana M 
Gene Ther. 2014 May;21(5):529-32



Ausgewählte Publikationen zu weiteren onkologischen Themen

Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) cells
Stuhldreier F, Kassel S, Schumacher L, Wesselborg S, Proksch P, Fritz G.
Cancer Lett. 2015 Feb 16

Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation

Busch M, Schwindt H, Brandt A, Beier M, Görldt N, Romaniuk P, Toska E, Roberts S, Royer HD, Royer-Pokora B.
Hum Mol Genet. 2014 Aug 1;23(15):3958-74
Evaluating the performance of clinical criteria for predicting mismatch repair gene mutations in Lynch syndrome: a comprehensive analysis of 3,671 families
Steinke V, Holzapfel S, Loeffler M, Holinski-Feder E, Morak M, Schackert HK, Görgens H, Pox C, Royer-Pokora B, von Knebel-Doeberitz M, Büttner R, Propping P, Engel C; German HNPCC Consortium.
Int J Cancer. 2014 Jul 1;135(1):69-77

Hematopoietic stem cells in neonates: any differences between very preterm and term neonates?

Wisgrill L, Schüller S, Bammer M, Berger A, Pollak A, Radke TF, Kögler G, Spittler A, Helmer H, Husslein P, Gortner L.
PLoS One. 2014 Sep 2;9(9):e106717
Prostacyclin suppresses twist expression in the presence of indomethacin in bone marrow-derived mesenchymal stromal cells
Kemper O, Herten M1, Fischer J, Haversath M, Beck S, Classen T, Warwas S, Tassemeier T, Landgraeber S, Lensing-Höhn S, Krauspe R, Jäger M.
Med Sci Monit. 2014 Nov 10;20:2219-27
Neuroendocrine neoplasms of the distal jejunum and ileum
Anlauf M, Sipos B, Boeck I, Baldus SE, Heikaus S, Krausch M, Knoefel WT, Begum N, Goretzki P, Schott M, Auernhammer CJ, Cremer B, Rinke A, Ezziddin S, Fottner C, Pöpperl G, Lahner H, Hörsch D, Gabbert HE, Komminoth P, Perren A, Klöppel G, Wiedenmann B, Pavel M, Pape U. 
Pathologe. 2014 May;35(3):283-93
Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors
Bopp A, Wartlick F, Henninger C, Schwarz M, Kaina B, Fritz G.
Carcinogenesis. 2015 Jan 2

mESC-based in vitro Differentiation Models to Study Vascular Response and Functionality Following Genotoxic Insults

Hennicke T, Nieweg K, Brockmann N, Kassack MU, Gottmann K, Fritz G.
Toxicol Sci. 2014 Dec 15

DEGRO practical guidelines for radiotherapy of breast cancer IV: radiotherapy following mastectomy for invasive breast cancer

Wenz F, Sperk E, Budach W, Dunst J, Feyer P, Fietkau R, Haase W, Harms W, Piroth MD, Sautter-Bihl ML, Sedlmayer F, Souchon R, Fussl C, Sauer R; Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO).
Strahlenther Onkol. 2014 Aug;190(8):705-14

Fiducial marker placement via conventional or electromagnetic navigation bronchoscopy (ENB): an interdisciplinary approach to the curative management of lung cancer

Hagmeyer L, Priegnitz C, Kocher M, Schilcher B, Budach W, Treml M, Stieglitz S, Randerath W.
Clin Respir J. 2014 Oct 13

Outcome impact and cost-effectiveness of quality assurance for radiotherapy planned for the EORTC 22071-24071 prospective study for head and neck cancer

Weber DC, Hurkmans CW, Melidis C, Budach W, Langendijk JH, Peters LJ, Grégoire V, 
Maingon P, Combescure C. 
Radiother Oncol. 2014 Jun;111(3):393-9

Postponed is not canceled: role of craniospinal radiation therapy in the management of recurrent infant medulloblastoma--an experience from the HIT-REZ 1997 & 2005 studies

Müller K, Mynarek M, Zwiener I, Siegler N, Zimmermann M, Christiansen H, Budach W, Henke G, Warmuth-Metz M, Pietsch T, von Hoff K, von Bueren A, Bode U, Rutkowski S, Kortmann RD, Fleischhack G, Tippelt S. 
Int J Radiat Oncol Biol Phys. 2014 Apr 1;88(5):1019-24

Does diffusion-weighted imaging improve therapy response evaluation in patients with hepatocellular carcinoma after radioembolization? comparison of MRI using Gd-EOB-DTPA with and without DWI

Schelhorn J, Best J, Reinboldt MP, Dechêne A, Gerken G, Ruhlmann M, Lauenstein TC, Antoch G, Kinner S.
J Magn Reson Imaging. 2014 Dec 17
An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism
Peitzsch M, Dekkers T, Haase M, Sweep FC, Quack I, Antoch G, Siegert G, Lenders JW, Deinum J, Willenberg HS, Eisenhofer G.
J Steroid Biochem Mol Biol. 2015 Jan;145:75-84
Quantitative volumetric CT-histogram analysis in N-staging of 18F-FDG-equivocal patients with lung cancer
Flechsig P, Kratochwil C, Schwartz LH, Rath D, Moltz J, Antoch G, Heussel CP, Rieser M, Warth A, Zabeck H, Kauczor HU, Haberkorn U, Giesel FL. 
J Nucl Med. 2014 Apr;55(4):559-64

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