Originalpublikationen 2007


Albrecht, U., Yang, X., Asselta, R., Keitel, V., Tenchini, M. L., Ludwig, S., Heinrich, P. C., Häussinger, D., Schaper, F. and Bode, J. G. (2007)
Activation of NF-kappaB by IL-1beta blocks IL-6-induced sustained STAT3 activation and STAT3-dependent gene expression of the human gamma-fibrinogen gene.
Cell Signal, 19: 1866-1878. (PubMed)

Becker, S., Reinehr, R., Graf, D., vom Dahl, S. and Häussinger, D. (2007)
Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation.
Cell Physiol Biochem, 19: 89-98. (PubMed)

Becker, S., Reinehr, R., Grether-Beck, S., Eberle, A. and Häussinger, D. (2007)
Hydrophobic bile salts trigger ceramide formation through endosomal acidification.
Biol Chem, 388: 185-196. (PubMed)

Bode, J. G., Brenndörfer, E. D. and Häussinger, D. (2007)
Subversion of innate host antiviral strategies by the hepatitis C virus.
Arch Biochem Biophys, 462: 254-265. (PubMed)

Buhler, K., Ufer, M., Müller-Marbach, A., Brinkmann, U., Laule, M., Stangl, V., Roots, I., Stangl, K. and Cascorbi, I. (2007)
Risk of coronary artery disease as influenced by variants of the human endothelin and endothelin-converting enzyme genes.
Pharmacogenet Genomics, 17: 77-83. (PubMed)

Cervantes-Barragan, L., Zust, R., Weber, F., Spiegel, M., Lang, K. S., Akira, S., Thiel, V. and Ludewig, B. (2007)
Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.
Blood, 109: 1131-1137. (PubMed)

Cornberg, M., Protzer, U., Dollinger, M. M., Petersen, J., Wedemeyer, H., Berg, T., Jilg, W., Erhardt, A., Wirth, S., Schirmacher, P., Fleig, W. E. and Manns, M. P. (2007)
[Prophylaxis, Diagnosis and Therapy of Hepatitis-B-Virus-(HBV-)Infection: upgrade of the guideline, AWMF-Register 021/011].
Prophylaxe, Diagnostik und Therapie der Hepatitis-B-Virus-(HBV-)Infektion - "Upgrade" der Leitlinie, AWMF-Register-Nr.: 021/011.
Z Gastroenterol, 45: 525-574. (PubMed)

Donner, M. G., Schumacher, S., Warskulat, U., Heinemann, J. and Häussinger, D. (2007)
Obstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2.
Am J Physiol Gastrointest Liver Physiol, 293: G1134-1146. (PubMed)

Eberle, A., Reinehr, R., Becker, S., Keitel, V. and Häussinger, D. (2007)
CD95 tyrosine phosphorylation is required for CD95 oligomerization.
Apoptosis, 12: 719-729. (PubMed)

Ehlting, C., Lai, W. S., Schaper, F., Brenndorfer, E. D., Matthes, R. J., Heinrich, P. C., Ludwig, S., Blackshear, P. J., Gaestel, M., Häussinger, D. and Bode, J. G. (2007)
Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade.
J Immunol, 178: 2813-2826. (PubMed)

Ehrhardt, C., Wolff, T., Pleschka, S., Planz, O., Beermann, W., Bode, J. G., Schmolke, M. and Ludwig, S. (2007)
Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.
J Virol, 81: 3058-3067. (PubMed)

Erhardt, A., Biburger, M., Papadopoulos, T. and Tiegs, G. (2007)
IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice.
Hepatology, 45: 475-485. (PubMed)

Eschli, B., Zellweger, R. M., Wepf, A., Lang, K. S., Quirin, K., Weber, J., Zinkernagel, R. M. and Hengartner, H. (2007)*
Early antibodies specific for the neutralizing epitope on the receptor binding subunit of the lymphocytic choriomeningitis virus glycoprotein fail to neutralize the virus.
J Virol, 81: 11650-11657. (PubMed)

Georgiev, P., Navarini, A. A., Eloranta, J. J., Lang, K. S., Kullak-Ublick, G. A., Nocito, A., Dahm, F., Jochum, W., Graf, R. and Clavien, P. A. (2007)*
Cholestasis protects the liver from ischaemic injury and post-ischaemic inflammation in the mouse.
Gut, 56: 121-128. (PubMed)

Gohla, A., Klement, K., Piekorz, R. P., Pexa, K., vom Dahl, S., Spicher, K., Dreval, V., Häussinger, D., Birnbaumer, L. and Nurnberg, B. (2007)
An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver.
Proc Natl Acad Sci U S A, 104: 3003-3008. (PubMed)

Görg, B., Qvartskhava, N., Voss, P., Grune, T., Häussinger, D. and Schliess, F. (2007)
Reversible inhibition of mammalian glutamine synthetase by tyrosine nitration.
FEBS Lett, 581: 84-90. (PubMed)

Graf, D., Bode, J. G. and Häussinger, D. (2007)
Caspases and receptor cleavage.
Arch Biochem Biophys, 462: 162-170. (PubMed)

Häussinger, D. and Schliess, F. (2007)
Glutamine metabolism and signaling in the liver.
Front Biosci, 12: 371-391. (PubMed)

Keitel, V., Reinehr, R., Gatsios, P., Rupprecht, C., Görg, B., Selbach, O., Häussinger, D. and Kubitz, R. (2007)
The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells.
Hepatology, 45: 695-704. (PubMed)

Kircheis, G., Fleig, W. E., Gortelmeyer, R., Grafe, S. and Häussinger, D. (2007)
Assessment of low-grade hepatic encephalopathy: a critical analysis.
J Hepatol, 47: 642-650. (PubMed)

Koch, S., Göbels, K., Richter, J., Oette, M. and Häussinger, D. (2007)
Cerebral malaria in spite of peripheral parasite clearance in a patient treated with atovaquone/proguanil.
Parasitol Res, 100: 747-748. (PubMed)

Kordes, C., Sawitza, I., Müller-Marbach, A., Ale-Agha, N., Keitel, V., Klonowski-Stumpe, H. and Häussinger, D. (2007)
CD133+ hepatic stellate cells are progenitor cells.
Biochem Biophys Res Commun, 352: 410-417. (PubMed)

Kubitz, R. and Häussinger, D. (2007)
Osmoregulation of bile formation.
Methods Enzymol, 428: 313-324. (PubMed)

Lang, K. S., Burow, A., Kurrer, M., Lang, P. A. and Recher, M. (2007)*
The role of the innate immune response in autoimmune disease.
J Autoimmun, 29: 206-212. (PubMed)

Lang, K. S., Hegazy, A. N., Lang, P. A., Eschli, B., Lohning, M., Hengartner, H., Zinkernagel, R. M. and Recher, M. (2007)*
"Negative vaccination" by specific CD4 T cell tolerisation enhances virus-specific protective antibody responses.
PLoS One, 2: e1162. (PubMed)

Lang, K. S., Navarini, A. A., Recher, M., Lang, P. A., Heikenwalder, M., Stecher, B., Bergthaler, A., Odermatt, B., Akira, S., Honda, K., Hengartner, H. and Zinkernagel, R. M. (2007)
MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus.
Eur J Immunol, 37: 2434-2440. (PubMed)

Lang, P. A., Schenck, M., Nicolay, J. P., Becker, J. U., Kempe, D. S., Lupescu, A., Koka, S., Eisele, K., Klarl, B. A., Rubben, H., Schmid, K. W., Mann, K., Hildenbrand, S., Hefter, H., Huber, S. M., Wieder, T., Erhardt, A., Häussinger, D., Gulbins, E. and Lang, F. (2007)
Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide.
Nat Med, 13: 164-170. (PubMed)

Lörke, J., Erhardt, A., Vogt, C. and Häussinger, D. (2007)
Nicht invasive Diagnostik der Leberzirrhose.
Dtsch Arztebl Int, 24: A1752-1757. (PubMed)

Lotscher, M., Recher, M., Lang, K. S., Navarini, A., Hunziker, L., Santimaria, R., Glatzel, M., Schwarz, P., Boni, J. and Zinkernagel, R. M. (2007)*
Induced prion protein controls immune-activated retroviruses in the mouse spleen.
PLoS One, 2: e1158. (PubMed)

Mückenfuss, H., Kaiser, J. K., Krebil, E., Battenberg, M., Schwer, C., Cichutek, K., Münk, C. and Flory, E. (2007)
Sp1 and Sp3 regulate basal transcription of the human APOBEC3G gene.
Nucleic Acids Res, 35: 3784-3796. (PubMed)

Münk, C., Zielonka, J., Constabel, H., Kloke, B. P., Rengstl, B., Battenberg, M., Bonci, F., Pistello, M., Lochelt, M. and Cichutek, K. (2007)
Multiple restrictions of human immunodeficiency virus type 1 in feline cells.
J Virol, 81: 7048-7060. (PubMed)

Oette, M., Kaiser, R., Daumer, M., Fatkenheuer, G., Rockstroh, J. K., Knechten, H., Mitrenga, D., Beerenwinkel, N., Sagir, A., Pfister, H. and Häussinger, D. (2007)
[Epidemiology of primary drug resistance in chronically HIV-infected patients in Nordrhein-Westfalen, Germany, 2001-2005].
Epidemiologie der primaren Medikamentenresistenz bei chronisch HIV-Infizierten in Nordrhein-Westfalen 2001-2005.
Dtsch Med Wochenschr, 132: 977-982. (PubMed)

Recher, M., Lang, K. S., Navarini, A., Hunziker, L., Lang, P. A., Fink, K., Freigang, S., Georgiev, P., Hangartner, L., Zellweger, R., Bergthaler, A., Hegazy, A. N., Eschli, B., Theocharides, A., Jeker, L. T., Merkler, D., Odermatt, B., Hersberger, M., Hengartner, H. and Zinkernagel, R. M. (2007)*
Extralymphatic virus sanctuaries as a consequence of potent T-cell activation.
Nat Med, 13: 1316-1323. (PubMed)

Reinehr, R., Görg, B., Becker, S., Qvartskhava, N., Bidmon, H. J., Selbach, O., Haas, H. L., Schliess, F. and Häussinger, D. (2007)
Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices.
Glia, 55: 758-771. (PubMed)

Reinehr, R. and Häussinger, D. (2007)
Hyperosmotic activation of the CD95 system.
Methods Enzymol, 428: 145-160. (PubMed)

Reinehr, R. and Häussinger, D. (2007)
CD95 activation in the liver: ion fluxes and oxidative signaling.
Arch Biochem Biophys, 462: 124-131. (PubMed)

Rits, M. A., van Dort, K. A., Münk, C., Meijer, A. B. and Kootstra, N. A. (2007)
Efficient transduction of simian cells by HIV-1-based lentiviral vectors that contain mutations in the capsid protein.
Mol Ther, 15: 930-937. (PubMed)

Rockel, N., Esser, C., Grether-Beck, S., Warskulat, U., Flogel, U., Schwarz, A., Schwarz, T., Yarosh, D., Häussinger, D. and Krutmann, J. (2007)
The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression.
J Immunol, 179: 3604-3612. (PubMed)

Sagir, A., Heintges, T., Akyazi, Z., Oette, M., Erhardt, A. and Häussinger, D. (2007)
Therapy outcome in patients with chronic hepatitis C: role of therapy supervision by expert hepatologists.
J Viral Hepat, 14: 633-638. (PubMed)

Sagir, A., Heintges, T., Akyazi, Z., Oette, M., Erhardt, A. and Häussinger, D. (2007)
Relapse to prior therapy is the most important factor for the retreatment response in patients with chronic hepatitis C virus infection.
Liver Int, 27: 954-959. (PubMed)

Sagir, A., Oette, M., Kaiser, R., Daumer, M., Fatkenheuer, G., Rockstroh, J. K., Knechten, H., Schmutz, G., Hower, M., Emmelkamp, J., Pfister, H. and Häussinger, D. (2007)
Trends of prevalence of primary HIV drug resistance in Germany.
J Antimicrob Chemother, 60: 843-848. (PubMed)

Schäfer, C., Gehrmann, T., Richter, L., Keitel, V., Köhrer, K., Häussinger, D. and Schliess, F. (2007)
Modulation of gene expression profiles by hyperosmolarity and insulin.
Cell Physiol Biochem, 20: 369-386. (PubMed)

Schäfer, C., Hoffmann, L., Heldt, K., Lornejad-Schäfer, M. R., Brauers, G., Gehrmann, T., Garrow, T. A., Häussinger, D., Mayatepek, E., Schwahn, B. C. and Schliess, F. (2007)
Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells.
Am J Physiol Gastrointest Liver Physiol, 292: G1089-1098. (PubMed)

Schliess, F. and Häussinger, D. (2007)
Osmosensing by integrins in rat liver.
Methods Enzymol, 428: 129-144. (PubMed)

Schliess, F., Reinehr, R. and Häussinger, D. (2007)
Osmosensing and signaling in the regulation of mammalian cell function.
FEBS J, 274: 5799-5803. (PubMed)

Schulze-Osthoff, K. and Häussinger, D. (2007)
Apoptosis in the liver: a matter of ion fluxes and oxidative stress: Third International Conference of the Collaborative Research Center 'Experimental Hepatology' (SFB-575), Dusseldorf, Germany, 13-14 October 2006.
Liver Int, 27: 1039-1044. (PubMed)

Sergeeva, O. A., Fleischer, W., Chepkova, A. N., Warskulat, U., Häussinger, D., Siebler, M. and Haas, H. L. (2007)
GABAA-receptor modification in taurine transporter knockout mice causes striatal disinhibition.
J Physiol, 585: 539-548. (PubMed)

Serrano, M. A., Macias, R. I., Briz, O., Monte, M. J., Blazquez, A. G., Williamson, C., Kubitz, R. and Marin, J. J. (2007)
Expression in human trophoblast and choriocarcinoma cell lines, BeWo, Jeg-3 and JAr of genes involved in the hepatobiliary-like excretory function of the placenta.
Placenta, 28: 107-117. (PubMed)

Warskulat, U., Borsch, E., Reinehr, R., Heller-Stilb, B., Roth, C., Witt, M. and Häussinger, D. (2007)
Taurine deficiency and apoptosis: findings from the taurine transporter knockout mouse.
Arch Biochem Biophys, 462: 202-209. (PubMed)

Warskulat, U., Brookmann, S., Reinen, A. and Häussinger, D. (2007)
Ultraviolet B radiation induces cell shrinkage and increases osmolyte transporter mRNA expression and osmolyte uptake in HaCaT keratinocytes.
Biol Chem, 388: 1345-1352. (PubMed)

Warskulat, U., Heller-Stilb, B., Oermann, E., Zilles, K., Haas, H., Lang, F. and Häussinger, D. (2007)
Phenotype of the taurine transporter knockout mouse.
Methods Enzymol, 428: 439-458. (PubMed)

Wedemeyer, H. and Erhardt, A. (2007)
Natürlicher Verlauf nd Therapie der chronischen Hepatits D.
Med Welt, 3: 100-105. (PubMed)

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